@article {2137,
	title = {Synthesis and Enzymatic Incorporation of Modified Deoxyadenosine Triphosphates},
	journal = {European Journal of Organic Chemistry},
	number = {29},
	year = {2008},
	note = {ISI Document Delivery No.: 365YXTimes Cited: 7Cited Reference Count: 35Lam, Curtis Hipolito, Christopher Perrin, David M.},
	month = {Oct},
	pages = {4915-4923},
	type = {Article},
	abstract = {Several deoxyadenosine triphosphates containing modifications at the 8-position have been synthesized. Suitably protected 8-bromodeoxyadenosines were coupled with five imidazole-containing moieties by nucleophilic aromatic substitution or Sonagashira coupling to give modified nucleosides that were then triphosphorylated. Incorporation assays were performed for these modified residues with many commercially available DNA polymerases, and it was found that two of the modified dATPs could be effectively taken up as substrates by Sequenase V2.0. These two residues are candidates for substrates in combinatorial selections in the search for improved catalysis from DNAzymes. ((C) Wiley-VCH Verlag GmbH \& Co. KGaA, 69451 Weinheim, Germany, 2008)},
	keywords = {AMINO-ACID, bioorganic chemistry, CATALYTIC REPERTOIRE, CLEAVING DNA ENZYME, DERIVATIVES, DNA, ENZYMES, FUNCTIONALITIES, HETEROCYCLES, IN-VITRO SELECTION, NUCLEIC-ACIDS, nucleotides, OLIGONUCLEOTIDES, PCR, POLYMERASES, SELEX},
	isbn = {1434-193X},
	url = {<Go to ISI>://000260447200009},
	author = {Lam, C. and Hipolito, C. and Perrin,David M.}
}
@article {1007,
	title = {High affinity DNAzyme-based ligands for transition metal cations - a prototype sensor for Hg2+},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {2},
	number = {3},
	year = {2004},
	note = {ISI Document Delivery No.: 776YCTimes Cited: 32Cited Reference Count: 47},
	month = {Feb},
	pages = {307-312},
	type = {Article},
	abstract = {Inspired by recent interest in DNAzymes as transition metal ion sensors, a survey of the effects of various transition metals on the intramolecular cleavage rate of an imidazole modified, M2+-independent, self-cleaving "9(25)-11" DNA is reported. In particular, 9(25)-11 activity was strongly inhibited by Hg2+ (K-d(APP) = 110 +/- 9 nM). It is postulated that the affinity and selectivity of 9(25)-11 for Hg2+ stems from the fact that this synthetically modified DNAzyme contains imidazoles. This study demonstrates the utility of modified nucleotides in developing DNAzyme sensors for metals ions, especially those for which unmodified nucleic acids might not serve as inherently good ligands.},
	keywords = {2-STEP MECHANISM, BIOSENSOR, CATALYTIC REPERTOIRE, CLEAVING DNA ENZYME, IMIDAZOLYL FUNCTIONALITIES, MERCURIC ION, MERCURY(II), NUCLEIC-ACIDS, NUCLEOSIDES, SELECTION},
	isbn = {1477-0520},
	url = {<Go to ISI>://000189146100008},
	author = {Thomas, J. M. and Ting, R. and Perrin,David M.}
}
@article {429,
	title = {Incorporation of 8-histaminyldeoxyadenosine [8-(2-(4-imidazolyl)ethylamino)-2 {\textquoteright}-deoxyriboadenosine] into oligodeoxyribonucleotides by solid phase phosphoramidite coupling},
	journal = {Nucleosides Nucleotides \& Nucleic Acids},
	volume = {21},
	number = {10},
	year = {2002},
	note = {ISI Document Delivery No.: 622CATimes Cited: 5Cited Reference Count: 37},
	pages = {651-664},
	type = {Article},
	abstract = {The 3{\textquoteright} phosphoramidite of 8-histaminyl deoxyadenosine has been prepared and successfully incorporated into a short oligodeoxyribonucleotide. The synthetic methodology leading to this preparation is given and the implications for developing new DNAzymes as well as probing unusual nucleic acid structures are discussed.},
	keywords = {BEARING IMIDAZOLE, CATALYTIC REPERTOIRE, CLEAVAGE, DERIVATIVES, DNA, IMIDAZOLYL FUNCTIONALITIES, NUCLEIC-ACIDS, OLIGONUCLEOTIDES, RIBONUCLEASES, RNA},
	isbn = {1525-7770},
	url = {<Go to ISI>://000179627900003},
	author = {Lermer, L. and Hobbs, J. and Perrin,David M.}
}
@article {430,
	title = {Toward an RNaseA mimic: a DNAzyme with imidazoles and cationic amines},
	journal = {Journal of the American Chemical Society},
	volume = {124},
	number = {34},
	year = {2002},
	note = {ISI Document Delivery No.: 586GJTimes Cited: 41Cited Reference Count: 52},
	month = {Aug},
	pages = {9960-9961},
	type = {Article},
	keywords = {CATALYTIC REPERTOIRE, CATIONS, CLEAVING DNA ENZYME, FUNCTIONALITIES, HAMMERHEAD, IN-VITRO SELECTION, MONOVALENT, NUCLEIC-ACIDS, RIBOZYME, SEQUENCE-SPECIFIC CLEAVAGE, SITE-SPECIFIC CLEAVAGE},
	isbn = {0002-7863},
	url = {<Go to ISI>://000177576000001},
	author = {Lermer, L. and Roupioz, Y. and Ting, R. and Perrin,David M.}
}
