@article {2287,
	title = {Toward [F-18]-labeled aryltrifluoroborate radiotracers: In vivo positron emission tomography imaging of stable aryltrifluoroborate clearance in mice},
	journal = {Journal of the American Chemical Society},
	volume = {130},
	number = {36},
	year = {2008},
	note = {ISI Document Delivery No.: 344TPTimes Cited: 15Cited Reference Count: 35Ting, Richard Harwig, Curtis auf dem Keller, Ulrich McCormick, Siobhan Austin, Pamela Overall, Christopher M. Adam, Michael J. Ruth, Thomas J. Perrin, David M.},
	month = {Sep},
	pages = {12045-12055},
	type = {Article},
	abstract = {The use of a boronic ester as a captor of aqueous [F-18]-fluoride has been previously suggested as a means of labeling biomolecules in one step for positron emission tomography (PET) imaging. For this approach to be seriously considered, the [F-18]-labeled trifluoroborate should be humorally stable such that it neither leaches free [F-18]-fluoride to the bone nor accumulates therein. Herein, we have synthesized a biotinylated boronic ester that is converted to the corresponding trifluoroborate salt in the presence of aqueous [F-18]-fluoride. In keeping with its in vitro aqueous kinetic stability at pH 7.5, the trifluoroborate appears to clear in vivo quite rapidly to the bladder as the stable trifluoroborate salt with no detectable leaching of free [F-18]-fluoride to the bone. When this labeled biotin is preincubated with avidin, the pharmacokinetic clearance of the resulting complex is visibly altered. This work validates initial claims that boronic esters are potentially useful as readily labeled precursors to [F-18]-PET reagents.},
	keywords = {apoptosis, BIODISTRIBUTION, CANCER, DESIGN, F-18, MICROPET, NO-CARRIER, PEPTIDES, PET, STABILITY},
	isbn = {0002-7863},
	url = {<Go to ISI>://000258950500044},
	author = {Ting, R. and Harwig, C. and auf dem Keller, U. and McCormick, S. and Austin, P. and Overall, C. M. and Adam,Michael J. and Ruth, T. J. and Perrin,David M.}
}
@article {2287,
	title = {Toward [F-18]-labeled aryltrifluoroborate radiotracers: In vivo positron emission tomography imaging of stable aryltrifluoroborate clearance in mice},
	journal = {Journal of the American Chemical Society},
	volume = {130},
	number = {36},
	year = {2008},
	note = {ISI Document Delivery No.: 344TPTimes Cited: 15Cited Reference Count: 35Ting, Richard Harwig, Curtis auf dem Keller, Ulrich McCormick, Siobhan Austin, Pamela Overall, Christopher M. Adam, Michael J. Ruth, Thomas J. Perrin, David M.},
	month = {Sep},
	pages = {12045-12055},
	type = {Article},
	abstract = {The use of a boronic ester as a captor of aqueous [F-18]-fluoride has been previously suggested as a means of labeling biomolecules in one step for positron emission tomography (PET) imaging. For this approach to be seriously considered, the [F-18]-labeled trifluoroborate should be humorally stable such that it neither leaches free [F-18]-fluoride to the bone nor accumulates therein. Herein, we have synthesized a biotinylated boronic ester that is converted to the corresponding trifluoroborate salt in the presence of aqueous [F-18]-fluoride. In keeping with its in vitro aqueous kinetic stability at pH 7.5, the trifluoroborate appears to clear in vivo quite rapidly to the bladder as the stable trifluoroborate salt with no detectable leaching of free [F-18]-fluoride to the bone. When this labeled biotin is preincubated with avidin, the pharmacokinetic clearance of the resulting complex is visibly altered. This work validates initial claims that boronic esters are potentially useful as readily labeled precursors to [F-18]-PET reagents.},
	keywords = {apoptosis, BIODISTRIBUTION, CANCER, DESIGN, F-18, MICROPET, NO-CARRIER, PEPTIDES, PET, STABILITY},
	isbn = {0002-7863},
	url = {<Go to ISI>://000258950500044},
	author = {Ting, R. and Harwig, C. and auf dem Keller, U. and McCormick, S. and Austin, P. and Overall, C. M. and Adam,Michael J. and Ruth, T. J. and Perrin,David M.}
}
@article {1289,
	title = {Arylfluoroborates and alkylfluorosilicates as potential PET imaging agents: High-yielding aqueous biomolecular F-18-labeling},
	journal = {Journal of the American Chemical Society},
	volume = {127},
	number = {38},
	year = {2005},
	note = {ISI Document Delivery No.: 968OCTimes Cited: 29Cited Reference Count: 32},
	month = {Sep},
	pages = {13094-13095},
	type = {Article},
	keywords = {AVIDIN, biotin, BORONIC ACIDS, CROSS-COUPLING REACTIONS, F-18, FRAGMENT, MICROPET, MONOCLONAL-ANTIBODY, PROTEIN, STATE},
	isbn = {0002-7863},
	url = {<Go to ISI>://000232170800007},
	author = {Ting, R. and Adam,Michael J. and Ruth, T. J. and Perrin,David M.}
}
@article {1289,
	title = {Arylfluoroborates and alkylfluorosilicates as potential PET imaging agents: High-yielding aqueous biomolecular F-18-labeling},
	journal = {Journal of the American Chemical Society},
	volume = {127},
	number = {38},
	year = {2005},
	note = {ISI Document Delivery No.: 968OCTimes Cited: 29Cited Reference Count: 32},
	month = {Sep},
	pages = {13094-13095},
	type = {Article},
	keywords = {AVIDIN, biotin, BORONIC ACIDS, CROSS-COUPLING REACTIONS, F-18, FRAGMENT, MICROPET, MONOCLONAL-ANTIBODY, PROTEIN, STATE},
	isbn = {0002-7863},
	url = {<Go to ISI>://000232170800007},
	author = {Ting, R. and Adam,Michael J. and Ruth, T. J. and Perrin,David M.}
}
@article {1052,
	title = {Radiohalogens for imaging and therapy},
	journal = {Chemical Society Reviews},
	volume = {34},
	number = {2},
	year = {2005},
	note = {ISI Document Delivery No.: 890PETimes Cited: 34Cited Reference Count: 41},
	pages = {153-163},
	type = {Review},
	abstract = {Radiohalogens play a very important role in radiopharmaceuticals used for medical imaging ( now referred to as molecular imaging) and therapy applications. Development of new radiopharmaceuticals that have radiohalogens incorporated requires an understanding of parameters that are unique to chemistry involving these radionuclides. Those parameters include requirement for production and purification of the halogen radionuclides, as well as development of reaction conditions for use with high specific activity short-lived radionuclides. In this tutorial review, several radiohalogens, their radiolabeling chemistry and their application to medical imaging and therapy are discussed.},
	keywords = {BRAIN, CANCER, F-18, LIGAND, MONOCLONAL-ANTIBODIES, PET, POSITRON-EMISSION-TOMOGRAPHY, RADIOIODINATION, RADIOTHERAPY, SPECT},
	isbn = {0306-0012},
	url = {<Go to ISI>://000226522500005},
	author = {Adam,Michael J. and Wilbur, D. S.}
}
@article {7320,
	title = {SYNTHESIS OF 2-DEOXY-2-[F-18]-FLUORO-BETA-MANNOSYL [F-18] FLUORIDE AS A POTENTIAL IMAGING PROBE FOR GLYCOSIDASES},
	journal = {Journal of Labelled Compounds \& Radiopharmaceuticals},
	volume = {31},
	number = {12},
	year = {1992},
	note = {ISI Document Delivery No.: KA889Times Cited: 6Cited Reference Count: 10},
	month = {Dec},
	pages = {1005-1009},
	type = {Article},
	abstract = {The mechanism-based glycosidase inhibitor 2-deoxy-2-[F-18]-fluoro-beta-mannosyl [F-18]-fluoride was synthesized and its covalent binding to Agrobacterium beta-glucosidase was demonstrated in vitro.},
	keywords = {BETA-GLYCOSIDASE, F-18, glycosyl fluoride, MECHANISM},
	isbn = {0362-4803},
	url = {<Go to ISI>://A1992KA88900006},
	author = {McCarter, J. D. and Adam,Michael J. and Withers, S. G.}
}
