@article {1209, title = {Vanadium complexes with mixed O,S anionic ligands derived from maltol: Synthesis, characterization, and biological studies}, journal = {Inorganic Chemistry}, volume = {44}, number = {8}, year = {2005}, note = {ISI Document Delivery No.: 916GWTimes Cited: 32Cited Reference Count: 45}, month = {Apr}, pages = {2678-2688}, type = {Article}, abstract = {Four mixed O,S binding bidentate ligand precursors derived from maltol (3-hydroxy-2-methyl-4-pyrone) have been chelated to vanadium to yield new bis(ligand)oxovanadium(IV) and tris(ligand)vanadium(III) complexes. The four ligand precursors include two pyranthiones, 3-hydroxy-2- m ethyl-4-pyranthione, commonly known as thiomaltol (Htma), and 2-ethyl-3-hydroxy-4-pyranthione, commonly known as ethylthiomaltol (Hetma), as well as two pyridinethiones, 3-hydroxy-2-methyl-4(H)-pyridinethione (Hmppt) and 3-hydroxy-1,2-dimethyi-4-pyridinethione (Hdppt). Vanadium complex formation was confirmed by elemental analysis, mass spectrometry, and IR and EPR (where possible) spectroscopies. The X-ray structure of oxobis(thiomaltolato)vanadium(IV),VO(tma)(2), was also determined; both cis and trans isomers were isolated in the same asymmetric unit. In both isomers, the two thiomaltolato ligands are arranged around the base of the square pyramid with the V=O linkage perpendicular; the vanadium atom is slightly displaced from the basal plane [V(1) = 0.656(3) angstrom, V(2) = 0.664(2) angstrom]. All of the new complexes were screened for insulin-enhancing effectiveness in streptozotocin-induced diabetes in rats, and VO(tma)2 was profiled metabolically for urinary vanadium and ligand clearance by GFAAS and ESIMS, respectively. The new vanadium complexes did not lower blood glucose levels acutely, possibly because of rapid dissociation and excretion.}, keywords = {BIOCHEMISTRY, BIS(MALTOLATO)OXOVANADIUM(IV), COORDINATION CHEMISTRY, CRYSTAL-STRUCTURE, EPR, IN-VITRO, METAL, OXOVANADIUM(IV)}, isbn = {0020-1669}, url = {://000228374400018}, author = {Monga, V. and Thompson, K. H. and Yuen, V. G. and Sharma, V. and Patrick, B. O. and McNeill, J. H. and Orvig, Chris} } @article {1209, title = {Vanadium complexes with mixed O,S anionic ligands derived from maltol: Synthesis, characterization, and biological studies}, journal = {Inorganic Chemistry}, volume = {44}, number = {8}, year = {2005}, note = {ISI Document Delivery No.: 916GWTimes Cited: 32Cited Reference Count: 45}, month = {Apr}, pages = {2678-2688}, type = {Article}, abstract = {Four mixed O,S binding bidentate ligand precursors derived from maltol (3-hydroxy-2-methyl-4-pyrone) have been chelated to vanadium to yield new bis(ligand)oxovanadium(IV) and tris(ligand)vanadium(III) complexes. The four ligand precursors include two pyranthiones, 3-hydroxy-2- m ethyl-4-pyranthione, commonly known as thiomaltol (Htma), and 2-ethyl-3-hydroxy-4-pyranthione, commonly known as ethylthiomaltol (Hetma), as well as two pyridinethiones, 3-hydroxy-2-methyl-4(H)-pyridinethione (Hmppt) and 3-hydroxy-1,2-dimethyi-4-pyridinethione (Hdppt). Vanadium complex formation was confirmed by elemental analysis, mass spectrometry, and IR and EPR (where possible) spectroscopies. The X-ray structure of oxobis(thiomaltolato)vanadium(IV),VO(tma)(2), was also determined; both cis and trans isomers were isolated in the same asymmetric unit. In both isomers, the two thiomaltolato ligands are arranged around the base of the square pyramid with the V=O linkage perpendicular; the vanadium atom is slightly displaced from the basal plane [V(1) = 0.656(3) angstrom, V(2) = 0.664(2) angstrom]. All of the new complexes were screened for insulin-enhancing effectiveness in streptozotocin-induced diabetes in rats, and VO(tma)2 was profiled metabolically for urinary vanadium and ligand clearance by GFAAS and ESIMS, respectively. The new vanadium complexes did not lower blood glucose levels acutely, possibly because of rapid dissociation and excretion.}, keywords = {BIOCHEMISTRY, BIS(MALTOLATO)OXOVANADIUM(IV), COORDINATION CHEMISTRY, CRYSTAL-STRUCTURE, EPR, IN-VITRO, METAL, OXOVANADIUM(IV)}, isbn = {0020-1669}, url = {://000228374400018}, author = {Monga, V. and Thompson, K. H. and Yuen, V. G. and Sharma, V. and Patrick, B. O. and McNeill, J. H. and Orvig, Chris} } @article {556, title = {Mononuclear to tetranuclear structural transformation in vanadyl complexes of 3-hydroxypyridine-2-carboxylic acid (H(2)hpic)}, journal = {Chemistry Letters}, number = {9}, year = {2002}, note = {ISI Document Delivery No.: 595RZTimes Cited: 13Cited Reference Count: 7}, month = {Sep}, pages = {916-917}, type = {Article}, abstract = {Reaction of vanadyl sulfate with 3-hydroxypyridine-2-carboxylic acid (H(2)hpic) affords two chargeless complexes, [VO(Hhpic-O,O)(Hhpic-O,N)(H2O)].3H(2)O (1) and unprecedented cyclic tetranuclear complex [(VO)(4)(mu-(hpic-O,O{\textquoteright},N))(H2O)(4)].8H(2)O (2), which were characterized by X-ray crystallographic analysis. The unique structural transformation between complexes 1 and 2 was found.}, keywords = {OXOVANADIUM(IV)}, isbn = {0366-7022}, url = {://000178123700023}, author = {Yano, S. and Nakai, M. and Sekiguchi, F. and Obata, M. and Kato, M. and Shiro, M. and Kinoshita, I. and Mikuriya, M. and Sakurai, H. and Orvig, Chris} }