@article {2388,
	title = {Potential new inorganic antitumour agents from combining the anticancer traditional Chinese medicine (TCM) liriodenine with metal ions, and DNA binding studies},
	journal = {Dalton Transactions},
	number = {2},
	year = {2009},
	note = {ISI Document Delivery No.: 385IHTimes Cited: 6Cited Reference Count: 68Chen, Zhen-Feng Liu, Yan-Cheng Liu, Li-Min Wang, Heng-Shan Qin, San-Hai Wang, Bo-Long Bian, He-Dong Yang, Bin Fun, Hoong-Kun Liu, Hua-Gang Liang, Hong Orvig, Chris},
	pages = {262-272},
	type = {Article},
	abstract = {Liriodenine (L), an active component of the anticancer traditional Chinese medicine (TCM), was isolated from Zanthoxylum nitidum. Its reactions with Pt(II) and Ru(II) afforded three metal complexes: cis-[PtCl2(L)] (1), cis-[PtCl2(L)(DMSO)] (2), and cis-[RuCl2(L)(DMSO)(2)]center dot 1.5H(2)O (3), the crystal structures of L, 2 and 3 were determined by single-crystal X-ray diffraction methods. These complexes were fully characterized by elemental analysis, IR spectrophotometry, H-1 and C-13 NMR spectroscopies, and ES mass spectrometry. The in vitro cytotoxicity of L and complexes 1-3 against 11 human tumour cell lines was assayed. The metal-based compounds exhibit enhanced cytotoxicity vs. free L, suggesting that these compounds display synergy in the combination of metal ions and liriodenine. The binding properties of L and its complexes 1-3 to ct-DNA were investigated through UV-vis, fluorescence, CD spectra, viscosity and agarose gels electrophoretic measurements.},
	keywords = {AFFINITY, ALKALOIDS, CISPLATIN, CYTOTOXIC ACTIVITY, DRUGS, FLUORESCENCE, IN-VITRO, PLATINUM(II) COMPLEXES, RUTHENIUM(II) COMPLEXES, TOPOISOMERASE-II},
	isbn = {1477-9226},
	url = {<Go to ISI>://000261807400006},
	author = {Chen, Z. F. and Liu, Y. C. and Liu, L. M. and Wang, H. S. and Qin, S. H. and Wang, B. L. and Bian, H. D. and Yang, B. and Fun, H. K. and Liu, H. G. and Liang, H. and Orvig, Chris}
}
@article {2130,
	title = {Total synthesis of (+)-fawcettidine},
	journal = {Angewandte Chemie-International Edition},
	volume = {47},
	number = {22},
	year = {2008},
	note = {ISI Document Delivery No.: 306QCTimes Cited: 22Cited Reference Count: 31Kozak, Jennifer A. Dake, Gregory R.},
	pages = {4221-4223},
	type = {Article},
	keywords = {ALKALOIDS, CATALYSIS, FAWCETTIMINE, GOLD, homogeneous catalysis, LYCOPODIUM ALKALOIDS, platinum, total synthesis},
	isbn = {1433-7851},
	url = {<Go to ISI>://000256261900037},
	author = {Kozak, J. A. and Dake, G. R.}
}
@article {1109,
	title = {An asymmetric formal synthesis of fasicularin},
	journal = {Chemistry-a European Journal},
	volume = {11},
	number = {2},
	year = {2005},
	note = {ISI Document Delivery No.: 887VLTimes Cited: 20Cited Reference Count: 138},
	month = {Jan},
	pages = {639-649},
	type = {Review},
	abstract = {An asymmetric formal synthesis of fasicularin (1) is described. This natural product, isolated from the extracts of the marine invertebrate Nephteis fasicularis, has shown modest cytotoxicity towards Vero cells. Fasicularin is among only two members of the cylindricine family of natural products, along with lepadiformine (2), to possess a trans A-B ring junction. Key steps of this approach to 1 involve a siloxy-epoxide semipinacol rearrangement of 5 to 6, a B-alkyl Suzuki-Miyaura coupling reaction by using enol trifluoromethanesulfonate 19 and a substrate-directed hydrogenation reaction of 24. This formal synthesis also highlights the difficulty in the incorporation of the thiocyanate functionality present in 1.},
	keywords = {ALKALOIDS, ALPHA-HYDROXY EPOXIDES, ASCIDIAN CLAVELINA-CYLINDRICA, BETA-SILOXY ALDEHYDES, CROSS-COUPLING, CROSS-COUPLING REACTION, DIELS-ALDER REACTION, ENANTIOSPECIFIC, EPOXY SILYL ETHERS, MARINE ALKALOID LEPADIFORMINE, REGIOSELECTIVE OLEFIN INSERTION, ring expansion, SEMI-PINACOL REARRANGEMENT, semipinacol rearrangement, spirocycle},
	isbn = {0947-6539},
	url = {<Go to ISI>://000226333500017},
	author = {Fenster, M. D. B. and Dake, G. R.}
}
@article {5069,
	title = {Construction of azaspirocyclic ketones through alpha-hydroxyiminium ion or alpha-siloxy epoxide semipinacol rearrangements},
	journal = {Organic Letters},
	volume = {3},
	number = {13},
	year = {2001},
	note = {ISI Document Delivery No.: 445ZDTimes Cited: 41Cited Reference Count: 22},
	month = {Jun},
	pages = {2109-2112},
	type = {Article},
	abstract = {[GRAPHICS] Semipinacol-type rearrangements to produce azaspirocyclic ketones are presented. The yields and stereoselectivities of these reactions range from 67-94\% yield and 2.8:1 to 1:0 diastereoselectivity, respectively.},
	keywords = {ACIDS, ALDOL PROCESS, ALKALOIDS, HALICHLORINE},
	isbn = {1523-7060},
	url = {<Go to ISI>://000169487700037},
	author = {Fenster, M. D. B. and Patrick, B. O. and Dake, G. R.}
}
@article {2788,
	title = {IGZAMIDE, A METABOLITE OF THE MARINE SPONGE PLOCAMISSMA-IGZO},
	journal = {Journal of Natural Products},
	volume = {56},
	number = {5},
	year = {1993},
	note = {ISI Document Delivery No.: LB497Times Cited: 12Cited Reference Count: 14},
	month = {May},
	pages = {792-794},
	type = {Note},
	abstract = {Igzamide [1], a new brominated tryptamine derivative, has been isolated from the northeastern Pacific sponge Plocamissa igzo.},
	keywords = {ALKALOIDS},
	isbn = {0163-3864},
	url = {<Go to ISI>://A1993LB49700022},
	author = {Dumdei, E. and Andersen, R. J.}
}
@article {7003,
	title = {NEAMPHINE, A SULFUR-CONTAINING AROMATIC HETEROCYCLE ISOLATED FROM THE MARINE SPONGE NEAMPHIUS-HUXLEYI},
	journal = {Tetrahedron Letters},
	volume = {32},
	number = {24},
	year = {1991},
	note = {ISI Document Delivery No.: FN524Times Cited: 9Cited Reference Count: 17},
	month = {Jun},
	pages = {2707-2710},
	type = {Article},
	abstract = {The structure of neamphine (1), a cytotoxic metabolite of the marine sponge Neamphius huxleyi, has been solved by single crystal x-ray diffraction analysis. Neamphine (1) represents the first example, either from nature or synthesis, of the imidazo[4,5-e]-1,2-thiazine ring system.},
	keywords = {ALKALOIDS, CYTOTOXIC, HETEROCYCLE, NITROGEN, SPONGE, SULFUR, TUNICATE},
	isbn = {0040-4039},
	url = {<Go to ISI>://A1991FN52400003},
	author = {De Silva, E. D. and Racok, J. S. and Andersen, R. J. and Allen, T. M. and Brinen, L. S. and Clardy, J.}
}
