@article {5219,
	title = {Binding of small alcohols to a lipid bilayer membrane: does the partitioning coefficient express the net affinity?},
	journal = {Biophysical Chemistry},
	volume = {89},
	number = {1},
	year = {2001},
	note = {ISI Document Delivery No.: 397WQTimes Cited: 13Cited Reference Count: 55},
	month = {Jan},
	pages = {53-63},
	type = {Article},
	abstract = {The total vapor pressures at 26 degreesC of binary (water-alcohol) and ternary (water-alcohol-vesicle) systems were measured for sis short chain alcohols. The vesicles were unilamellar dipalmitoyl phosphatidylcholine (DMPC). The data was used to evaluate the effect of vesicles on the chemical potential of alcohols expressed as the preferential binding parameter of the alcohol-lipid interaction, Gamma (23). This quantity is a thermodynamic (model-free) measure of the net strength of membrane-alcohol interactions. For the smaller investigated alcohols (methanol, ethanol and 1-propanol) Gamma (23) was negative. This is indicative of so-called preferential hydration, a condition where the affinity of the membrane for water is higher than the affinity for the alcohol. For the longer alcohols (1-butanol, 1-pentanol, 1-hexanol) Gamma (23) was positive and increasing with increasing chain length. This demonstrates preferential binding, i.e. enrichment of alcohol in the membrane and a concomitant depletion of the solute in the aqueous bulk. The measured values of Gamma (23) were compared to the number of alcohol-membrane contacts specified by partitioning coefficients from the literature. It was found that for the small alcohols the number of alcohol-membrane contacts is much larger than the number of preferentially bound solutes. This discrepancy, which is theoretically expected in cases of very weak binding, becomes less pronounced with increasing alcohol chain length, and when the partitioning coefficient exceeds approximately 3 on the molal scale (10(2) in mole fraction units) it vanishes. Based on this, relationships between structural and thermodynamic interpretations of membrana partitioning are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.},
	keywords = {energy of interaction, ETHANOL, free, lipid membranes, membrane partitioning, MODEL, NONELECTROLYTE PARTITION, PHASE, PHOSPHATIDYLCHOLINE, preferential binding, protein stability, SOLUTES, THERMODYNAMICS, vapor pressure, VAPOR-PRESSURE, WATER},
	isbn = {0301-4622},
	url = {<Go to ISI>://000166721200005},
	author = {Westh, P. and Trandum, C. and Koga,Yoshikata}
}
@article {4587,
	title = {Fluctuations in aqueous methanol, ethanol, and propan-1-ol: amplitude and wavelength of fluctuation},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {77},
	number = {12},
	year = {1999},
	note = {ISI Document Delivery No.: 262KYTimes Cited: 29Cited Reference Count: 18},
	month = {Dec},
	pages = {2039-2045},
	type = {Article},
	abstract = {Density, heat capacity, and isentropic compressibility data for aqueous methanol, ethanol, and propan-1-ol by Benson{\textquoteright}s group were used to evaluate two kinds of fluctuations; mean-square fluctuation densities; and (mean-square) normalized fluctuations, respectively, in volume, entropy, and cross (entropy/volume) effect. The mean-square fluctuation densities provide measures for the amplitude (intensity) of the fluctuation, while the normalized fluctuations contain information regarding the wavelength (extensity) of the fluctuation. Furthermore, their composition derivatives, the partial molar fluctuations of alcohols were calculated. These quantities signify the effect of additional solute on the respective fluctuations. These data were interpreted in terms of mixing schemes learned earlier in this laboratory by using the data of excess partial molar enthalpy, entropy, and volume, and the respective alcohol-alcohol interaction functions, i.e., the composition derivatives of partial molar quantities.},
	keywords = {25-DEGREES-C, and propan-1-ol, aqueous methanol, ETHANOL, fluctuation density, HEAT-CAPACITIES, LIQUID WATER, N-ALCOHOL MIXTURES, NON-ELECTROLYTES, normalized fluctuation, partial molar fluctuations of alcohol, THERMODYNAMICS, VOLUMES},
	isbn = {0008-4042},
	url = {<Go to ISI>://000084067500005},
	author = {Koga,Yoshikata}
}
@article {3830,
	title = {Excess partial molar enthalpies of alkane-mono-ols in aqueous solutions},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {74},
	number = {5},
	year = {1996},
	note = {ISI Document Delivery No.: UP791Times Cited: 50Cited Reference Count: 29},
	month = {May},
	pages = {713-721},
	type = {Article},
	abstract = {Excess partial molar enthalpies, H-A(E), of methanol, ethanol, and 1- and 2-propanols in aqueous solutions were measured directly, accurately, and in small increments in mole fraction at 25 degrees C. From these data, the solute-solute enthalpic interactions, H-AA(E) = N(partial derivative H-A(E)/partial derivative n(A)), were evaluated for each alcohol. These data indicate that three distinctively different mixing schemes, I, II, and III exist, as was the case for aqueous 2-butoxyethanol previously studied in our laboratory. The transition from mixing scheme I to II appears to take place gradually within a small composition range. As the hydrophobic moiety becomes smaller from 2-butoxyethanol to methanol, the locus of the transition moves to a higher value in mole fraction of the alcohol. At the same time, the range of transition becomes wider and the solute-solute enthalpic interaction weaker.},
	keywords = {1-PROPANOL, 2-BUTOXYETHANOL, 2-PROPANOL, 25-DEGREES-C, BUTYL ALCOHOL-SOLUTIONS, CONCENTRATION FLUCTUATIONS, enthalpic interaction, ENTROPIES, ETHANOL, excess partial molar enthalpies in aqueous solutions, FREE-ENERGIES, METHANOL, MIXING SCHEME, TERT-BUTANOL MIXTURES, TRANSITION, transition of, WATER-RICH REGION},
	isbn = {0008-4042},
	url = {<Go to ISI>://A1996UP79100011},
	author = {Tanaka, S. H. and Yoshihara, H. I. and Ho, A. W. C. and Lau, F. W. and Westh, P. and Koga,Yoshikata}
}
