@article {1219,
	title = {Synthesis and insulin-mimetic activities of metal complexes with 3-hydroxypyridine-2-carboxylic acid},
	journal = {Journal of Inorganic Biochemistry},
	volume = {99},
	number = {6},
	year = {2005},
	note = {ISI Document Delivery No.: 934IJTimes Cited: 16Cited Reference Count: 28},
	month = {Jun},
	pages = {1275-1282},
	type = {Article},
	abstract = {Metal complexes of 3-hydroxypyridine-2-carboxylic acid (H(2)hpic), [Co(Hhpic)(2)(H2O)(2)] (1), [Fe(Hhpic)(2)(H2O)(2)] (2), [Zn(Hhpic)(2)(H2O)(2)] (3), [Mn(Hhpic)(2)(H2O)(2)] (4), and [Cu(Hhpic)(2)] (5) have been synthesized and characterized by mass spectrometry, elemental analysis, magnetic susceptibility, infrared, electronic absorption and electron paramagnetic resonance (EPR) spectroscopies. The solid-state structure of 1 has been established by X-ray crystallography. The EPR spectra of 4 and 5 displayed six and four-line hyperfine splitting patterns, respectively, due to coupling of the unpaired electron with the Mn-55 (I=5/2) nucleus and the Cu-63 (I=3/2) nucleus. In the EPR spectrum of 5, an additional five-line super-hyperfine splitting pattern was observed at 77 K, caused by additional interaction of the unpaired electron with ligand nitrogen atoms (I=1), indicating that the structure of 5 was retained in dimethyl sulfoxide solution. The insulin-mimetic activity of these complexes was evaluated by means of in vitro measurements of the inhibition of free fatty acid (FFA) release from epinephrine-treated, isolated rat adipocytes. Complex 5 was found to exhibit the most potent insulin-mimetic activity among the complexes examined in this study. (C) 2005 Elsevier Inc. All rights reserved.},
	keywords = {3-hydroxypyridine-2-carboxylic acid (H(2)hpic), CHEMISTRY, DIABETIC-RATS, GLUCOSE, insulin-mimetic drug, MECHANISM, MONONUCLEAR, RAT ADIPOCYTES, VANADIUM},
	isbn = {0162-0134},
	url = {<Go to ISI>://000229702200002},
	author = {Nakai, M. and Sekiguchi, F. and Obata, M. and Ohtsuki, C. and Adachi, Y. and Sakurai, H. and Orvig, Chris and Rehder, D. and Yano, S.}
}
@inbook {1012,
	title = {Vanadium compounds in the treatment of diabetes},
	booktitle = {Metal Ions in Biological Systems, Vol 41: Metal Ions and Their Complexes in Medication},
	series = {Metal Ions in Biological Systems},
	volume = {41},
	year = {2004},
	note = {ISI Document Delivery No.: BBZ13Times Cited: 38Cited Reference Count: 148Review270 MADISON AVE, NEW YORK, NY 10016 USA},
	pages = {221-252},
	publisher = {Marcel Dekker},
	organization = {Marcel Dekker},
	address = {New York},
	keywords = {ELECTRON-PARAMAGNETIC-RESONANCE, GLUCOSE-HOMEOSTASIS, IMPROVES GLYCEMIC CONTROL, IN-VIVO, INSULIN-RESISTANCE, ISOLATED, METALLOKINETIC ANALYSIS, OXYGEN-BRIDGED DIMER, PEROXOVANADIUM COMPOUNDS, PHOSPHOTYROSINE PHOSPHATASE INHIBITORS, RAT ADIPOCYTES},
	isbn = {0161-5149},
	url = {<Go to ISI>://000228348900007},
	author = {Thompson, K. H. and Orvig, Chris}
}
@article {742,
	title = {Vanadyl-thiazolidinedione combination agents for diabetes therapy},
	journal = {Bioconjugate Chemistry},
	volume = {14},
	number = {1},
	year = {2003},
	note = {ISI Document Delivery No.: 637YYTimes Cited: 23Cited Reference Count: 42},
	month = {Jan-Feb},
	pages = {212-221},
	type = {Article},
	abstract = {A series of vanadium compounds, chelated by ligands containing a thiazolidinedione moiety as an additional insulin-enhancing component, were produced in this study to create potentially synergistic compounds. A set of four bifunctional ligand precursors were synthesized: (+/-)-5-4-[(5-hydroxy-4-oxo-4H-pyran-2-ylmethyl)amino]benzylthiazolidi ne-2,4-dione (HL1), (+/-)-5-4-[5-hydroxy-1-methyl-4-oxo-1,4-dihydro-pyridin-2-ylmethyl)amin o]benzylthiazolidine-2,4-dione (HL2) 5-[4-(5-hydroxy-4-oxo-4H-pyran-2-ylmethoxy)benzylidenelthiazolidine-2,4- dione (HL1), and (+/-)-5-4-(5-hydroxy-4-oxo-4H-pyran-2-ylmethoxy)benzyl]thiazolidine-2,4 -dione (HL4), each containing a metal chelating portion as well as a thiazolidinedione moiety. From this set of ligand precursors, air-stable VO(L-1)(2), VO(L-3)(2), and VO(L-4)(2) were prepared. The four ligand precursors and three complexes were tested for insulin-enhancing potential in STZ-diabetic rats and compared to rosiglitazone and BMOV, respectively. Both the ligand precursors HL1 and HL3 showed enhanced activity compared with that of rosiglitazone. The complex VO(L-3)(2) showed the most efficacious hypoglycemic effects in this study; however, neither additive nor synergistic effects were observed using this acute animal model.},
	keywords = {AGENT, ANTIHYPERGLYCEMIC, BIOLOGICAL-ACTIVITY, BIS(MALTOLATO)OXOVANADIUM(IV), BLOOD-GLUCOSE, COMPLEXES, DERIVATIVES, GLUCOSE-LOWERING PROPERTIES, INSULIN MIMETIC AGENT, RAT ADIPOCYTES, TROGLITAZONE},
	isbn = {1043-1802},
	url = {<Go to ISI>://000180542400025},
	author = {Storr, T. and Mitchell, D. and Buglyo, P. and Thompson, K. H. and Yuen, V. G. and McNeill, J. H. and Orvig, Chris}
}
@article {3827,
	title = {Oxidation kinetics of the potent insulin mimetic agent bis(maltolato)oxovanadium(IV) (BMOV) in water and in methanol},
	journal = {Inorganic Chemistry},
	volume = {35},
	number = {6},
	year = {1996},
	note = {ISI Document Delivery No.: UA169Times Cited: 58Cited Reference Count: 45},
	month = {Mar},
	pages = {1667-1673},
	type = {Article},
	abstract = {{The kinetics of oxidation of bis(maltolato)oxovanadium(IV), BMOV or VO(ma)(2), by dioxygen have been studied by UV-vis spectroscopy in both MeOH and H2O media. The VO(ma)(2):O-2 stoichiometry was 4:1. In aqueous solution, the pH-dependeut rate of the VO(ma)(2)/O-2 reaction to generate cis-[VO2(ma)(2)](-) is attributed to the deprotonation of coordinated H2O, the deprotonated species [VO(ma)(2)(OH)](-) being more easily oxidized (k(OH) = 0.39 M(-1) s(-1), 25 degrees C) than the neutral form VO(ma)(2)(H2O) (k(H2O) = 0.08 M(-1) s(-1), 25 degrees C). The activation parameters for the two second-order reactions in aqueous solution were deduced from variable temperature kinetic measurements. In MeOH, VO(ma)(2) was oxidized by dioxygen to cis-VO(OMe)(ma)(2), whose structure was characterized by single-crystal X-ray diffraction; the crystals were monoclinic, C2/c, with a = 28.103(1) Angstrom},
	keywords = {ANATION, AQUEOUS-SOLUTION, COMPLEXES, CYSTEINE, KINASE, RAT ADIPOCYTES, VANADYL TREATMENT},
	isbn = {0020-1669},
	url = {<Go to ISI>://A1996UA16900042},
	author = {Sun, Y. and James, Brian R. and Rettig, S. J. and Orvig, Chris}
}
@article {3827,
	title = {Oxidation kinetics of the potent insulin mimetic agent bis(maltolato)oxovanadium(IV) (BMOV) in water and in methanol},
	journal = {Inorganic Chemistry},
	volume = {35},
	number = {6},
	year = {1996},
	note = {ISI Document Delivery No.: UA169Times Cited: 58Cited Reference Count: 45},
	month = {Mar},
	pages = {1667-1673},
	type = {Article},
	abstract = {{The kinetics of oxidation of bis(maltolato)oxovanadium(IV), BMOV or VO(ma)(2), by dioxygen have been studied by UV-vis spectroscopy in both MeOH and H2O media. The VO(ma)(2):O-2 stoichiometry was 4:1. In aqueous solution, the pH-dependeut rate of the VO(ma)(2)/O-2 reaction to generate cis-[VO2(ma)(2)](-) is attributed to the deprotonation of coordinated H2O, the deprotonated species [VO(ma)(2)(OH)](-) being more easily oxidized (k(OH) = 0.39 M(-1) s(-1), 25 degrees C) than the neutral form VO(ma)(2)(H2O) (k(H2O) = 0.08 M(-1) s(-1), 25 degrees C). The activation parameters for the two second-order reactions in aqueous solution were deduced from variable temperature kinetic measurements. In MeOH, VO(ma)(2) was oxidized by dioxygen to cis-VO(OMe)(ma)(2), whose structure was characterized by single-crystal X-ray diffraction; the crystals were monoclinic, C2/c, with a = 28.103(1) Angstrom},
	keywords = {ANATION, AQUEOUS-SOLUTION, COMPLEXES, CYSTEINE, KINASE, RAT ADIPOCYTES, VANADYL TREATMENT},
	isbn = {0020-1669},
	url = {<Go to ISI>://A1996UA16900042},
	author = {Sun, Y. and James, Brian R. and Rettig, S. J. and Orvig, Chris}
}
