@article {2628,
	title = {Glycosylated tetrahydrosalens as multifunctional molecules for Alzheimer{\textquoteright}s therapy},
	journal = {Dalton Transactions},
	number = {16},
	year = {2009},
	note = {ISI Document Delivery No.: 430GYTimes Cited: 8Cited Reference Count: 65Storr, Tim Scott, Lauren E. Bowen, Meryn L. Green, David E. Thompson, Katherine H. Schugar, Harvey J. Orvig, Chris},
	pages = {3034-3043},
	type = {Article},
	abstract = {The tetrahydrosalens N,N{\textquoteright}-bis(2-hydroxybenzyl)-ethane-1,2-diamine (H2L1), N, N{\textquoteright}-bis(2-hydroxybenzyl)-(-)-1,2-cyclohexane-(1R, 2R)-diamine (H2L2), N,N{\textquoteright}-bis(2-hydroxybenzyl)-N,N{\textquoteright}-dimethyl-ethane-1,2-diamine (H2L3), N,N{\textquoteright}-bis(2-hydroxybenzyl)-N,N{\textquoteright}-dibenzyl-ethane-1,2diamine (H2L4), and N,N{\textquoteright}-bis(2-(4-tert-butyl) hydroxybenzyl)-ethane-1,2-diamine (H2L5), as well as their prodrug glycosylated forms, GL(1-5), have been prepared and evaluated in vitro for their potential use as Alzheimer{\textquoteright}s disease (AD) therapeutics. Dysfunctional interactions of metal ions, especially those of Cu, Zn, and Fe, with the amyloid-beta (A beta) peptide are hypothesised to play an important role in the aetiology of AD, and disruption of these aberrant metal-peptide interactions via chelation therapy holds considerable promise as a therapeutic strategy. Tetrahydrosalens such as H2L1-5 have a significant affinity for metal ions, and thus should be able to compete with the A beta peptide for Cu, Zn, and Fe in the brain. This activity was assayed in vitro via a turbidity assay; H2L1 and H2L3 were found to attenuate A beta(1-40) aggregation after exposure to Cu2+ and Zn2+. In addition, H2L1-5 were determined to be potent antioxidants on the basis of an in vitro antioxidant assay. GL(1-5) were prepared as metal binding prodrugs; glycosylation is intended to prevent systemic metal binding, improve solubility, and enhance brain uptake. Enzymatic (beta-glucosidase) deprotection of the carbohydrate moieties was facile, with the exception of GL(4), demonstrating the general feasibility of this prodrug approach. Finally, a representative prodrug, GL(3), was determined to be non-toxic over a large concentration range in a cell viability assay.},
	keywords = {A-BETA, ACTIVITY, antioxidant, COMPLEXES, DISEASE, HYDROGEN-PEROXIDE, IN-VITRO, NEURODEGENERATIVE DISORDERS, OXIDATIVE STRESS, TRANSGENIC MICE, zinc},
	isbn = {1477-9226},
	url = {<Go to ISI>://000264978300018},
	author = {Storr, T. and Scott, L. E. and Bowen, M. L. and Green, D. E. and Thompson, K. H. and Schugar, H. J. and Orvig, Chris}
}
@article {3961,
	title = {Chiral and achiral diphosphine complexes of ruthenium(II) incorporating labile nitrile ligands: Synthesis and solution chemistry of mono- and dinuclear derivatives of Ru2Cl4(PP)(2) (PP equals chelating diphosphine)},
	journal = {Inorganic Chemistry},
	volume = {36},
	number = {9},
	year = {1997},
	note = {ISI Document Delivery No.: WW128Times Cited: 25Cited Reference Count: 36},
	month = {Apr},
	pages = {1961-1966},
	type = {Article},
	abstract = {A family of nitrile complexes has been prepared by reaction of Ru2Cl4(PP)(2) Or RuCl2(PP)(PPh3) (PP = Ph2P(CH2)(4)PPh2 (dppb), Ph2PCH2CHOCMe2OCHCH2PPh2 (diop), 2,2{\textquoteright}-bis(diphenylphosphino)-1, 1{\textquoteright}-binaphthyl (binap)) with MeCN or PhCN, the product formed depending strongly on the reaction conditions. At high nitrile concentrations, the principal species present is RuCl(PP)(RCN)(3)X-+(-) (X = Cl); the cation can generally be isolated (as the PF6 salt) by abstraction of the chloride counterion with NH4PF6. Use of 2 equiv of NH4PF6 generates Ru(PP)(RCN)(4)(2+)(PF6-)(2) (PP = dppb). In the absence of a halide-abstracting agent, addition of hexanes or diethyl ether precipitates neutral RuCl2(PP)(RCN)(2) species, which undergo further loss of nitrile in the solid state (R = Me) or in solution (R = Me, Ph). Redissolution of the neutral species in chlorocarbon solvents gives Ru2Cl3(PP)(2)(RCN)(2)X-+(-) (X = Cl) and, in benzene, Ru2Cl4(PP)(2)(RCN). The dinuclear cation (X = PF6) is also accessible by reaction of RuCl(PP)(RCN)(3)+PF6- with CH2Cl2 or CDCl3, while the mononitrile can be obtained directly by reaction of Ru2Cl4(PP)(2) or RuCl2(PP)(PPh3) with small amounts of nitrile in benzene.},
	keywords = {ACTIVATION, ACTIVITY, CARBOXYLIC-ACIDS, CATALYTIC, DICHLOROMETHANE, DIHYDROGEN, DITERTIARY-PHOSPHINE COMPLEXES, GENERATION, HYDROGENATION, OXIDATIVE-ADDITION-REACTIONS, SOLVENT},
	isbn = {0020-1669},
	url = {<Go to ISI>://A1997WW12800034},
	author = {Fogg, D. E. and James, Brian R.}
}
