@article {2121,
	title = {Making connections for life: an in vivo map of the yeast interactome},
	journal = {Hfsp Journal},
	volume = {2},
	number = {5},
	year = {2008},
	note = {ISI Document Delivery No.: 355VHTimes Cited: 1Cited Reference Count: 28Kast, Juergen},
	month = {Oct},
	pages = {244-250},
	type = {Article},
	abstract = {Proteins are the true workhorses of any cell. To carry out specific tasks, they frequently bind other molecules in their surroundings. Due to their structural complexity and flexibility, the most diverse array of interactions is seen with other proteins. The different geometries and affinities available for such interactions typically bestow specific functions on proteins. Having available a map of protein - protein interactions is therefore of enormous importance for any researcher interested in gaining insight into biological systems at the level of cells and organisms. In a recent report, a novel approach has been employed that relies on the spontaneous folding of complementary enzyme fragments fused to two different proteins to test whether these interact in their actual cellular context [Tarassov et al., Science 320, 1465-1470 (2008)]. Genome- wide application of this protein- fragment complementation assay has resulted in the first map of the in vivo interactome of Saccharomyces cerevisiae. The current data show striking similarities but also significant differences to those obtained using other large- scale approaches for the same task. This warrants a general discussion of the current state of affairs of protein - protein interaction studies and foreseeable future trends, highlighting their significance for a variety of applications and their potential to revolutionize our understanding of the architecture and dynamics of biological systems.},
	keywords = {AMINO-ACIDS, CELL-CULTURE, COMPLEXES, CROSS-LINKING, IDENTIFICATION, MASS-SPECTROMETRY, PROTEIN-PROTEIN INTERACTIONS, QUANTIFICATION, QUANTITATION, SACCHAROMYCES-CEREVISIAE},
	isbn = {1955-2068},
	url = {<Go to ISI>://000259736700002},
	author = {Kast, J.}
}
@article {2288,
	title = {Substituent effects on aryltrifluoroborate solvolysis in water: Implications for Suzuki-Miyaura coupling and the design of stable F-18-labeled aryltrifluoroborates for use in PET imaging},
	journal = {Journal of Organic Chemistry},
	volume = {73},
	number = {12},
	year = {2008},
	note = {ISI Document Delivery No.: 313RGTimes Cited: 17Cited Reference Count: 41Ting, Richard Harwig, Curtis W. Lo, Justin Li, Ying Adam, Michael J. Ruth, Thomas J. Perrin, David M.},
	month = {Jun},
	pages = {4662-4670},
	type = {Article},
	abstract = {Whereas electron withdrawing substituents retard the rate of aryltrifluoroborate solvolysis, electron-donating groups enhance it. Herein is presented a Hammett analysis of the solvolytic lability of aryltrifluoroborates where log(k(solv)) values correlate to sigma values with a rho value of approximately -1. This work provides a predictable rubric for tuning the reactivity of boron for several uses including F-18-labeled PET reagents and has mechanistic implications for ArBF3-enhanced ligandless metal-mediated cross coupling reactions with aryltrifluoroborates.},
	keywords = {AMINO-ACIDS, AROMATIC SUBSTITUTION, CHEMISTRY, CHYMOTRYPSIN, CONSTANTS, FLUORIDE, HYDROLYSIS, ORGANOBORON COMPOUNDS, POTASSIUM ARYL, TRIFLUOROMETHYL GROUP},
	isbn = {0022-3263},
	url = {<Go to ISI>://000256757100038},
	author = {Ting, R. and Harwig, C. W. and Lo, J. and Li, Y. and Adam,Michael J. and Ruth, T. J. and Perrin,David M.}
}
@article {2288,
	title = {Substituent effects on aryltrifluoroborate solvolysis in water: Implications for Suzuki-Miyaura coupling and the design of stable F-18-labeled aryltrifluoroborates for use in PET imaging},
	journal = {Journal of Organic Chemistry},
	volume = {73},
	number = {12},
	year = {2008},
	note = {ISI Document Delivery No.: 313RGTimes Cited: 17Cited Reference Count: 41Ting, Richard Harwig, Curtis W. Lo, Justin Li, Ying Adam, Michael J. Ruth, Thomas J. Perrin, David M.},
	month = {Jun},
	pages = {4662-4670},
	type = {Article},
	abstract = {Whereas electron withdrawing substituents retard the rate of aryltrifluoroborate solvolysis, electron-donating groups enhance it. Herein is presented a Hammett analysis of the solvolytic lability of aryltrifluoroborates where log(k(solv)) values correlate to sigma values with a rho value of approximately -1. This work provides a predictable rubric for tuning the reactivity of boron for several uses including F-18-labeled PET reagents and has mechanistic implications for ArBF3-enhanced ligandless metal-mediated cross coupling reactions with aryltrifluoroborates.},
	keywords = {AMINO-ACIDS, AROMATIC SUBSTITUTION, CHEMISTRY, CHYMOTRYPSIN, CONSTANTS, FLUORIDE, HYDROLYSIS, ORGANOBORON COMPOUNDS, POTASSIUM ARYL, TRIFLUOROMETHYL GROUP},
	isbn = {0022-3263},
	url = {<Go to ISI>://000256757100038},
	author = {Ting, R. and Harwig, C. W. and Lo, J. and Li, Y. and Adam,Michael J. and Ruth, T. J. and Perrin,David M.}
}
@article {1391,
	title = {Synthesis, structure, and biological activity of ferrocenyl carbohydrate conjugates},
	journal = {Inorganic Chemistry},
	volume = {45},
	number = {20},
	year = {2006},
	note = {ISI Document Delivery No.: 086ZJTimes Cited: 6Cited Reference Count: 82Ferreira, Cara L. Ewart, Charles B. Barta, Cheri A. Little, Susan Yardley, Vanessa Martins, Candice Polishchuk, Elena Smith, Peter J. Moss, John R. Merkel, Michael Adam, Michael J. Orvig, Chris},
	month = {Oct},
	pages = {8414-8422},
	type = {Article},
	abstract = {Seven ferrocenyl carbohydrate conjugates were synthesized. Coupling reactions of monosaccharide derivatives with ferrocene carbonyl chloride produced {6-N-(methyl 2,3,4-tri-O-acetyl-6-amino-6-deoxy-R-D-glucopyranoside)}1- ferrocene carboxamide (3), {1-O-(2,3,4,6-tetra-O-benzyl-D-glucopyranose)}-1-ferrocene carboxylate (4), and {6O- (1,2,3,4-tetra-O-acetyl-beta-D-glucopyranose)}-1-ferrocene carboxylate (5). Similarly, 1,1{\textquoteright}-bis(carbonyl chloride)ferrocene was coupled with the appropriate sugars to produce the disubstituted analogues bis {6-N-(methyl 2,3,4-tri- O-acetyl-6-amino-6-deoxy-R-D-glucopyranoside)}- 1,1{\textquoteright}-ferrocene carboxamide (8), bis {1-O-(2,3,4,6-tetra-O-benzyl-D- glucopyranose)}- 1,1{\textquoteright}-ferrocene carboxylate (9), and bis {6-O-(1,2,3,4-tetra-O-acetyl-beta-D-glucopyranose)}- 1,1{\textquoteright}-ferrocene carboxylate (10). {6-N-(Methyl-6-amino-6-deoxy-R-D-glucopyranoside)}-1-ferrocene carboxamide monohydrate (12) was synthesized via amide coupling of an activated ferrocenyl ester with the corresponding carbohydrate. All compounds were characterized by elemental analysis, H-1 NMR spectroscopy, and mass spectrometry. X-ray crystallography confirmed the solid-state structure of three ferrocenyl carbohydrate conjugates: 2-N-(1,3,4,6-tetra-O- acetyl-2-amino-2-deoxy-D-glucopyranose)-1-ferrocene carboxamide (1), 1-S-(2,3,4,6-tetra-O-acetyl-1-deoxy-1-thio-D- glucopyranose)-1-ferrocene carboxylate (2), and 12. The above compounds, along with bis {2-N- ( 1,3,4,6-tetra-O- acetyl-2-amino-2-deoxy-D-glucopyranose)}-1,1{\textquoteright}-ferrocene carboxamide (6), bis {1- S- (2,3,4,6-tetra-O- acetyl-1-deoxy-1- thio-D-glucopyranose)}- 1,1{\textquoteright}-ferrocene carboxylate (7), and 2-N-(2-amino-2-deoxy-D-glucopyranose)-1-ferrocene carboxamide (11) were examined for cytotoxicity in cell lines (L1210 and HTB-129) and for antimalarial activity in Plasmodium falciparum strains (D10, 3D7, and K1, a chloroquine- resistant strain). In general, the compounds were nontoxic in the human cell line tested (HTB-129), and compounds 4, 7, and 9 showed moderate antimalarial activity in one or more of the P. falciparum strains.},
	keywords = {ACTIVITY IN-VITRO, AMINO-ACIDS, ANTIMALARIAL ACTIVITY, CHLOROQUINE COMPLEXES, DRUG-SENSITIVITY, ELECTROCHEMICAL STUDY/, METAL-BASED CHEMOTHERAPY, ORGANOMETALLIC ANALOG, PLASMODIUM-FALCIPARUM, TROPICAL DISEASES},
	isbn = {0020-1669},
	url = {<Go to ISI>://000240711500054},
	author = {Ferreira, C. L. and Ewart, C. B. and Barta, C. A. and Little, S. and Yardley, V. and Martins, C. and Polishchuk, E. and Smith, P. J. and Moss, J. R. and Merkel, M. and Adam,Michael J. and Orvig, Chris}
}
@article {1391,
	title = {Synthesis, structure, and biological activity of ferrocenyl carbohydrate conjugates},
	journal = {Inorganic Chemistry},
	volume = {45},
	number = {20},
	year = {2006},
	note = {ISI Document Delivery No.: 086ZJTimes Cited: 6Cited Reference Count: 82Ferreira, Cara L. Ewart, Charles B. Barta, Cheri A. Little, Susan Yardley, Vanessa Martins, Candice Polishchuk, Elena Smith, Peter J. Moss, John R. Merkel, Michael Adam, Michael J. Orvig, Chris},
	month = {Oct},
	pages = {8414-8422},
	type = {Article},
	abstract = {Seven ferrocenyl carbohydrate conjugates were synthesized. Coupling reactions of monosaccharide derivatives with ferrocene carbonyl chloride produced {6-N-(methyl 2,3,4-tri-O-acetyl-6-amino-6-deoxy-R-D-glucopyranoside)}1- ferrocene carboxamide (3), {1-O-(2,3,4,6-tetra-O-benzyl-D-glucopyranose)}-1-ferrocene carboxylate (4), and {6O- (1,2,3,4-tetra-O-acetyl-beta-D-glucopyranose)}-1-ferrocene carboxylate (5). Similarly, 1,1{\textquoteright}-bis(carbonyl chloride)ferrocene was coupled with the appropriate sugars to produce the disubstituted analogues bis {6-N-(methyl 2,3,4-tri- O-acetyl-6-amino-6-deoxy-R-D-glucopyranoside)}- 1,1{\textquoteright}-ferrocene carboxamide (8), bis {1-O-(2,3,4,6-tetra-O-benzyl-D- glucopyranose)}- 1,1{\textquoteright}-ferrocene carboxylate (9), and bis {6-O-(1,2,3,4-tetra-O-acetyl-beta-D-glucopyranose)}- 1,1{\textquoteright}-ferrocene carboxylate (10). {6-N-(Methyl-6-amino-6-deoxy-R-D-glucopyranoside)}-1-ferrocene carboxamide monohydrate (12) was synthesized via amide coupling of an activated ferrocenyl ester with the corresponding carbohydrate. All compounds were characterized by elemental analysis, H-1 NMR spectroscopy, and mass spectrometry. X-ray crystallography confirmed the solid-state structure of three ferrocenyl carbohydrate conjugates: 2-N-(1,3,4,6-tetra-O- acetyl-2-amino-2-deoxy-D-glucopyranose)-1-ferrocene carboxamide (1), 1-S-(2,3,4,6-tetra-O-acetyl-1-deoxy-1-thio-D- glucopyranose)-1-ferrocene carboxylate (2), and 12. The above compounds, along with bis {2-N- ( 1,3,4,6-tetra-O- acetyl-2-amino-2-deoxy-D-glucopyranose)}-1,1{\textquoteright}-ferrocene carboxamide (6), bis {1- S- (2,3,4,6-tetra-O- acetyl-1-deoxy-1- thio-D-glucopyranose)}- 1,1{\textquoteright}-ferrocene carboxylate (7), and 2-N-(2-amino-2-deoxy-D-glucopyranose)-1-ferrocene carboxamide (11) were examined for cytotoxicity in cell lines (L1210 and HTB-129) and for antimalarial activity in Plasmodium falciparum strains (D10, 3D7, and K1, a chloroquine- resistant strain). In general, the compounds were nontoxic in the human cell line tested (HTB-129), and compounds 4, 7, and 9 showed moderate antimalarial activity in one or more of the P. falciparum strains.},
	keywords = {ACTIVITY IN-VITRO, AMINO-ACIDS, ANTIMALARIAL ACTIVITY, CHLOROQUINE COMPLEXES, DRUG-SENSITIVITY, ELECTROCHEMICAL STUDY/, METAL-BASED CHEMOTHERAPY, ORGANOMETALLIC ANALOG, PLASMODIUM-FALCIPARUM, TROPICAL DISEASES},
	isbn = {0020-1669},
	url = {<Go to ISI>://000240711500054},
	author = {Ferreira, C. L. and Ewart, C. B. and Barta, C. A. and Little, S. and Yardley, V. and Martins, C. and Polishchuk, E. and Smith, P. J. and Moss, J. R. and Merkel, M. and Adam,Michael J. and Orvig, Chris}
}
@article {1524,
	title = {Unambiguous determination of the ionization state of a glycoside hydrolase active site lysine by H-1-N-15 heteronuclear correlation spectroscopy},
	journal = {Journal of the American Chemical Society},
	volume = {128},
	number = {48},
	year = {2006},
	note = {ISI Document Delivery No.: 110GSTimes Cited: 15Cited Reference Count: 15Poon, David K. Y. Schubert, Mario Au, Jason Okon, Mark Withers, Stephen G. McIntosh, Lawrence P.},
	month = {Dec},
	pages = {15388-15389},
	type = {Article},
	keywords = {AMINO-ACIDS, beta, EXCHANGE, MAGNETIC-RESONANCE, NMR, PROTEINS},
	isbn = {0002-7863},
	url = {<Go to ISI>://000242367000018},
	author = {Poon, D. K. Y. and Schubert, M. and Au, J. and Okon, M. and Withers, S. G. and McIntosh, L. P.}
}
@article {4368,
	title = {Chiral synthesis of tri-O-methylimbricatine, an etherified derivative of the starfish alkaloid imbricatine},
	journal = {Tetrahedron Letters},
	volume = {39},
	number = {33},
	year = {1998},
	note = {ISI Document Delivery No.: 104XFTimes Cited: 6Cited Reference Count: 14},
	month = {Aug},
	pages = {5999-6002},
	type = {Article},
	abstract = {A chiral synthesis of tri-O-methylimbricatine (2), the tri-O-methyl derivative of the unique benzyltetrahydroisoquinoline alkaloid imbricatine (1) isolated from the starfish Dermasterias imbricata, has been accomplished. As a result of the synthesis, the correctness of the structure and absolute stereochemistry proposed for imbricatine has been unequivocally confirmed. (C) 1998 Elsevier Science Ltd. All rights reserved.},
	keywords = {amino acids and derivatives, AMINO-ACIDS, DERMASTERIAS-IMBRICATA, imidazoles/imidazolines, isoquinolines, REAGENTS, thioethers},
	isbn = {0040-4039},
	url = {<Go to ISI>://000075041200034},
	author = {Ohba, M. and Nishimura, Y. and Imasho, M. and Fujii, T. and Kubanek, J. and Andersen, R. J.}
}
@article {4448,
	title = {A phosphinate inhibitor of the meso-diaminopimelic acid-adding enzyme (MurE) of peptidoglycan biosynthesis},
	journal = {Journal of Organic Chemistry},
	volume = {63},
	number = {26},
	year = {1998},
	note = {ISI Document Delivery No.: 153LPTimes Cited: 37Cited Reference Count: 50},
	month = {Dec},
	pages = {10081-10085},
	type = {Article},
	keywords = {AMINO-ACIDS, COLI GLUTAMINE-SYNTHETASE, D-ALANINE LIGASE, ESCHERICHIA-COLI, GLUTATHIONE SYNTHETASE, INACTIVATION, KINETIC MECHANISM, MECHANISM-BASED, N-ACETYLMURAMATE, RAPID-QUENCH, VANCOMYCIN RESISTANCE},
	isbn = {0022-3263},
	url = {<Go to ISI>://000077834800087},
	author = {Zeng, B. Q. and Kwong, K. and Pompliano, D. L. and Reddy, S. and Tanner, M. E.}
}
@article {3851,
	title = {Ferintoic acids A and B, new cyclic hexapeptides from the freshwater cyanobacterium Microcystis aeruginosa},
	journal = {Journal of Natural Products},
	volume = {59},
	number = {6},
	year = {1996},
	note = {ISI Document Delivery No.: UT658Times Cited: 23Cited Reference Count: 30},
	month = {Jun},
	pages = {570-575},
	type = {Article},
	abstract = {The cyclic hexapeptides ferintoic acids A (1) and B (2) have been isolated from cells of Microcystis aeruginosa harvested during a natural bloom of the toxic cyanobacterium. The structures of 1 and 2 were determined by a combination of spectroscopic analysis and chemical degradation.},
	keywords = {AMINO-ACIDS, BLUE-GREEN-ALGA, INHIBITOR, LR, PEPTIDE, PHASE, PROTEIN PHOSPHATASES, SPONGE THEONELLA SP, TOXIN},
	isbn = {0163-3864},
	url = {<Go to ISI>://A1996UT65800004},
	author = {Williams, D. E. and Craig, M. and Holmes, C. F. B. and Andersen, R. J.}
}
@article {3762,
	title = {The pK(a) of the general acid/base carboxyl group of a glycosidase cycles during catalysis: A C-13-NMR study of Bacillus circuluns xylanase},
	journal = {Biochemistry},
	volume = {35},
	number = {31},
	year = {1996},
	note = {ISI Document Delivery No.: VB211Times Cited: 149Cited Reference Count: 43},
	month = {Aug},
	pages = {9958-9966},
	type = {Article},
	abstract = {The 20 kDa xylanase from Bacillus circulans carries out hydrolysis of xylan via a two-step mechanism involving a covalent glycosyl-enzyme intermediate. In this double-displacement reaction, Glu78 functions as a nucleophile to form the intermediate, while Glu172 acts as a general acid catalyst during glycosylation, protonating the departing aglycone, and then as a general base during deglycosylation, deprotonating the attacking water, The dual role of Glu172 places specific demands upon its ionization states and hence pK(a) values. C-13-NMR titrations of xylanase, labeled with [delta-C-13]glutamic acid, have revealed pK(a) values of 4.6 and 6.7 for Glu78 and Glu172, respectively. These agree well with the apparent pK(a) values obtained from a study of the pH dependence of k(cat)/K-m and demonstrate that, at the enzyme{\textquoteright}s pH optimum of 5.7, the nucleophile Glu78 is deprotonated and the general acid Glu172 initially protonated. Remarkably, the pK(a) for Glu172 drops to 4.2 in a trapped covalent glycosyl-enzyme intermediate, formed by reaction with 2{\textquoteright},4{\textquoteright}-dinitrophenyl 2-deoxy-2-fluoro-beta-xylobioside [Miao et al. (1994) Biochemistry 33, 7027-7032], A similar pK(a) is measured for Glu172 when a glutamine is present at position 78. This large decrease in pK(a) of similar to 2.5 units is consistent with the role of Glu172 as a general base catalyst in the deglycosylation step and appears to be a consequence of both reduced electrostatic repulsion due to neutralization of Glu78 and a conformational change in the protein. Such {\textquoteright}{\textquoteright}pK(a) cycling{\textquoteright}{\textquoteright} during catalysis is likely to be a common phenomenon in glycosidases.},
	keywords = {ACTIVE-SITE RESIDUES, AMINO-ACIDS, beta-glucosidase, ELECTROSTATIC INTERACTIONS, ESCHERICHIA-COLI, IDENTIFICATION, LYSOZYME, MECHANISMS, NUCLEAR-MAGNETIC-RESONANCE, PROTEINS},
	isbn = {0006-2960},
	url = {<Go to ISI>://A1996VB21100003},
	author = {McIntosh, L. P. and Hand, G. and Johnson, P. E. and Joshi, M. D. and Korner, M. and Plesniak, L. A. and Ziser, L. and Wakarchuk, W. W. and Withers, S. G.}
}
@article {2932,
	title = {THE ISOLATION OF MAJUSCULAMIDE-C FROM THE SPONGE PTILOCAULIS-TRACHYS COLLECTED IN ENEWETAK AND DETERMINATION OF THE ABSOLUTE-CONFIGURATION OF THE 2-METHYL-3-AMINOPENTANOIC ACID RESIDUE},
	journal = {Journal of Natural Products},
	volume = {56},
	number = {4},
	year = {1993},
	note = {ISI Document Delivery No.: KX568Times Cited: 19Cited Reference Count: 24},
	month = {Apr},
	pages = {545-551},
	type = {Article},
	abstract = {Majusculamide C [1], a cyclic depsipeptide metabolite of the blue-green alga Lyngbya majuscula, has been isolated from the sponge Ptilocaulis trachys collected at Enewetak Atoll in the Marshall Islands. The absolute configuration of the novel beta amino acid 2-methyl-3-aminopentanoic acid (MAP), a component of the structure of 1, has been determined to be 2S,3R.},
	keywords = {AMINO-ACIDS, BIOACTIVE MARINE METABOLITES, CYCLIC DEPSIPEPTIDE, CYCLODEPSIPEPTIDES, LYNGBYA-MAJUSCULA, PEPTIDE, THEONELLA SP},
	isbn = {0163-3864},
	url = {<Go to ISI>://A1993KX56800015},
	author = {Williams, D. E. and Burgoyne, D. L. and Rettig, S. J. and Andersen, R. J. and Fathiafshar, Z. R. and Allen, T. M.}
}
@article {7287,
	title = {PSEUDOAXINELLIN, A CYCLIC HEPTAPEPTIDE ISOLATED FROM THE PAPUA-NEW-GUINEA SPONGE PSEUDOAXINELLA-MASSA},
	journal = {Tetrahedron Letters},
	volume = {33},
	number = {23},
	year = {1992},
	note = {ISI Document Delivery No.: HX160Times Cited: 18Cited Reference Count: 21},
	month = {Jun},
	pages = {3269-3272},
	type = {Article},
	abstract = {Pseudoaxinellin (1), a new cyclic heptapeptide, has been isolated from the marine sponge Pseudoaxinella massa collected in Papua New Guinea. The structure of 1 was solved by spectroscopic analysis and chemical degradation. Pseudoaxinellin is the first cyclic heptapeptide reported from a marine source. One of the amide bonds in 1 is cis.},
	keywords = {AMINO-ACIDS, BIOACTIVE MARINE METABOLITES, PEPTIDE, THEONELLA},
	isbn = {0040-4039},
	url = {<Go to ISI>://A1992HX16000005},
	author = {Kong, F. M. and Burgoyne, D. L. and Andersen, R. J. and Allen, T. M.}
}
