@article {LIU2023133941,
	title = {Plant polysaccharide itself as hydrogen bond donor in a deep eutectic system-based mechanochemical extraction method},
	journal = {Food Chemistry},
	volume = {399},
	year = {2023},
	month = {01/2023},
	pages = {133941},
	type = {Research},
	abstract = {<p>A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES). The extraction efficiency is enhanced by the direct formation of the DESys, in a mechanochemical extraction (MCE) system. Key factors affecting the extraction efficiency were systematically studied and optimized. The effects of the DESys on the structure and physicochemical properties of polysaccharides were studied by several analytical techniques. The findings demonstrated that the direct DESys formation extraction efficiency was superior than that of traditional extraction methods while retaining physicochemical properties of polysaccharides. Moreover, the composition of polysaccharides extracted with this method is different from that obtained by conventional methods. The recovery and purification process of polysaccharides is simplified by eliminating the need for an additional HBD.</p>},
	keywords = {Deep eutectic solvents (DES), Deep eutectic system (DESys), hydrogen bonds, Plant natural products, POLYSACCHARIDE},
	issn = {0308-8146},
	doi = {https://doi.org/10.1016/j.foodchem.2022.133941},
	url = {https://www.sciencedirect.com/science/article/pii/S0308814622019033},
	author = {Min Liu and Simin Wang and Wentao Bi and David D. Y. Chen}
}
@article {828,
	title = {A one-pot synthesis and X-ray crystallographic and computational analyses of methyl-2,4-dimethoxysalicylate - a potential anti-tumour agent},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {82},
	number = {7},
	year = {2004},
	note = {ISI Document Delivery No.: 861XBTimes Cited: 5Cited Reference Count: 34},
	month = {Jul},
	pages = {1179-1185},
	type = {Article},
	abstract = {The thermal decarboxylation of 2-methoxycarbonyl-5-(4{\textquoteright}-nitrophen-oxy)tetrazole (1a) with the electron-rich, aromatic compounds (anisole, N,N-dimethylaniline, 1,4-dimethoxybenzene, and 1,3,5-trimethoxybenzene), neat or in polar solvents (DMSO, DMF, and CH3CN), is investigated. The solid phase thermal decomposition of a mixture of 1a, 1,3,5-trimethoxybenzene, and a Lewis acid (AlCl3) produces methyl-2,4-dimethoxysalicylate (8) in good yield, instead of the expected 2,4,6-trimethoxybenzoic acid. The X-ray structure of 8 shows intramolecular hydrogen bonds between the carbonyl oxygen and hydrogens of Me and OH groups. A measured pK(a) value of 6.8 compares well with a value of 6.4 estimated using the [C=O...H...O] hydrogen bond distances.},
	keywords = {2{\textquoteright}, 6{\textquoteright}-DIMETHOXYFLAVONE, ACID, anti-tumor, computational analysis, hydrogen bonds, HYDROGEN-BOND DATA, novel synthesis, PK(A), TETRAZOLES, X-ray structure},
	isbn = {0008-4042},
	url = {<Go to ISI>://000224450800007},
	author = {Dabbagh, H. A. and Noroozi-Pesyan, N. and Patrick, B. O. and James, Brian R.}
}
