@article {2521,
	title = {Inactivity of iridium-triphenylphosphine complexes for catalytic imine hydrogenation: formation of neutral, dihydrido-ortho-metallated species},
	journal = {Reaction Kinetics and Catalysis Letters},
	volume = {98},
	number = {2},
	year = {2009},
	note = {ISI Document Delivery No.: 519XSTimes Cited: 0Cited Reference Count: 32Marcazzan, Paolo James, Brian R.},
	month = {Dec},
	pages = {193-204},
	type = {Article},
	abstract = {Reactions of cis,trans,cis-[Ir(H)(2)(PPh3)(2)(MeOH)(2)]PF6 in MeOH with the imines Ph(R{\textquoteright})C=NR under 1 atm H-2 precipitate the neutral, Ir(III)-dihydrido complexes [Ir(H)(2){RN=C(R{\textquoteright})(o-C H-6(4))}(PPh3)(2)], where R = alkyl or benzyl, and R{\textquoteright} = Ph, H, or Me; the dihydrides are well characterized through elemental analysis, NMR and IR data and, in one case, with the imine Ph2C=NCH2Ph, an X-ray structure. These products are formed via intermediate ortho-metallated species, exemplified by [Ir(H){PhCH2N=CPh(o-C H-6(4))}(PPh3)(2)(MeOH)]PF6 in the case of the Ph2C=NCH2Ph reaction; the intermediate then reacts with H-2 (via net heterolytic cleavage: H-2 -> H- + H+) to give the neutral dihydride and HPF6 as co-product. The {\textquoteright}unique{\textquoteright} imine PhCH=NPh, under the same conditions, does not form a dihydride and instead is readily catalytically hydrogenated to PhCH2N(H)Ph; remarkably, we have shown previously that this imine is {\textquoteright}unique{\textquoteright} within the corresponding Rh system in that no catalytic hydrogenation occurs because the amine product {\textquoteright}poisons{\textquoteright} the Rh centre by coordination through the N-phenyl ring.},
	keywords = {CHEMISTRY, DIHYDROGEN, H-2, Hydrido-complexes, IMINE HYDROGENATION, Ortho-metallation, PROTONS, TRANS-INFLUENCE, xx Iridium phosphine complexes},
	isbn = {0133-1736},
	url = {<Go to ISI>://000271803800001},
	author = {Marcazzan, P. and James, Brian R.}
}
@article {4012,
	title = {Synthesis of chiral amines catalyzed homogeneously by metal complexes},
	journal = {Catalysis Today},
	volume = {37},
	number = {2},
	year = {1997},
	note = {ISI Document Delivery No.: XQ681Times Cited: 86Cited Reference Count: 73},
	month = {Aug},
	pages = {209-221},
	type = {Article},
	abstract = {This review describes developments in catalytic asymmetric hydrogenation of prochiral imines. The homogeneous systems were initially dominated by ones based on Rh complexes containing chiral, chelating diphosphine ligands, although related Ru-and Ir-based systems are becoming more prominent; a very recent, extremely effective hydrogen transfer system (from formic acid), based on Ru catalysts containing chiral 1,2-diamine ligands, is especially significant. A fundamentally different type involving an early transition-metal catalyst (a chiral titanocene) has been reported. Enantiomeric excess (e.e.) values in the range of 90-100\% have now been achieved with certain substrates. Emphasis is given to some Rh and Ru catalysts developed in the Department of Chemistry, The University of British Columbia (UBC). Factors discussed include: dependence of conversions, rates and e.e. values on substrate and catalyst type; kinetic dependences; and mechanistic insights, especially possible roles of intermediate metal-hydride and -imine species.},
	keywords = {ASYMMETRIC REDUCTIVE AMINATION, DIASTEREOSELECTIVE, HIGHLY ENANTIOSELECTIVE HYDROGENATION, HYDROGENATION, IMINE HYDROGENATION, KINETIC, PHOSPHINE COMPLEXES, RESOLUTION, rhodium, RUTHENIUM(II) COMPLEXES, SYSTEMS, TITANOCENE CATALYST},
	isbn = {0920-5861},
	url = {<Go to ISI>://A1997XQ68100009},
	author = {James, Brian R.}
}
@article {3028,
	title = {A COMPARISON OF CATALYTIC ACTIVITY FOR IMINE HYDROGENATION USING RU DITERTIARY PHOSPHINE COMPLEXES, INCLUDING CHIRAL SYSTEMS},
	journal = {Inorganica Chimica Acta},
	volume = {222},
	number = {1-2},
	year = {1994},
	note = {ISI Document Delivery No.: PD174Times Cited: 39Cited Reference Count: 45},
	month = {Jul},
	pages = {85-90},
	type = {Article},
	abstract = {A family of ruthenium ditertiary phosphine complexes was investigated for catalytic activity toward imine hydrogenation. The diphosphines (PP) used include chiral (chiraphos, diop, binap) and achiral (dppe, dppb) systems (chiraphos = Ph2PCH(Me)CH(Me)PPh2; diop = Ph2PCH2CHOCMe2OCHCH2PPh2; binap = 2,2{\textquoteright}-bis(diphenylphosphino)-1,1{\textquoteright}-binaphthyl; Ph2P(CH2)(n)PPh2 (n = 2, dppe; n = 4, dppb)). Activity was observed in MeOH at low catalyst concentrations (0.77 mM Ru), under moderate conditions (room temperature (r.t.), 1000 psi H2). The air-stable Ru2Cl5(PP)2 complexes were more active than the commonly used dimeric Ru2(II,II) systems to which they give rise in situ. Asymmetric induction in the prochiral ketimine PhCH2N = C(Me)Ph was consistent, though modest, within the diop and binap series of neutral complexes, implying a common catalytic intermediate within each series. A maximum e.e. of 27\% was found using Ru2Cl5(chiraphos)2 as catalyst; this represents a non-optimized figure for asymmetric induction, as no other prochiral ketimines were screened.},
	keywords = {1{\textquoteright}-BINAPHTHYL, 2, 2{\textquoteright}-BIS(DIPHENYLPHOSPHINO)-1, ACIDS, ASYMMETRIC HYDROGENATION, BINAP, CATALYSIS, DIPHOSPHINE, ENANTIOSELECTIVE, HYDROGENATION, IMINE HYDROGENATION, LIGANDS, NITRILE COMPLEXES, PHOSPHINE COMPLEXES, ruthenium complexes, X-ray structure},
	isbn = {0020-1693},
	url = {<Go to ISI>://A1994PD17400011},
	author = {Fogg, D. E. and James, Brian R. and Kilner, M.}
}
