@article {4167,
	title = {Glucose-lowering properties of vanadium compounds: Comparison of coordination complexes with maltol or kojic acid as ligands},
	journal = {Journal of Inorganic Biochemistry},
	volume = {68},
	number = {2},
	year = {1997},
	note = {ISI Document Delivery No.: YA963Times Cited: 72Cited Reference Count: 44},
	month = {Nov},
	pages = {109-116},
	type = {Article},
	abstract = {Bis(kojato)oxovanadium(IV) [abbreviated VO(ka)(2)], a close chemical analog of the insulin-mimetic lead compound bis(maltolato) oxovanadium (IV) - abbreviated BMOV or VO(ma)(2) - is reported and its reaction chemistry and insulin-mimetic properties are presented. VO(ka)(2) [log K-1 = 7.61(10), log K-2 = 6.89(6), log beta(2) = 14.50(16)] has a reaction chemistry which directly parallels that of VO(ma)(2). In aqueous solution it is more slowly oxidized by molecular oxygen to [VO2(ka)(2)](-) than is VO(ma)(2) to [VO2(ma)(2)](-). Variable pH electrochemistry and variable pH V-51 NMR of solutions of VO(Ka)(2) are presented and contrasted with the corresponding results for VO(ma)(2). Time course studies (24 hr) in Sn-diabetic rats following the oral or ip administration of VO(ka)(2), VO(ma)(2), VO2+ (vanadyl) as vanadyl sulfate (VOSO4), and [VO2(ma)(2)](-) as its [NH4](+) salt have been performed, as have chronic oral studies comparing VO(ka)(2) and VO(ma)(2) over a six week period. lit all studies, the most potent form of vanadium was the neutrally charged water soluble, complex VO(ma)(2). (C) 1997 Elsevier Science Inc.},
	keywords = {ALUMINUM(III), BIOINORGANIC CHEMISTRY, BIS(MALTOLATO)OXOVANADIUM(IV) BMOV, DIABETIC RATS, INHIBITOR, INSULIN MIMETIC AGENT, ISOLATED RAT ADIPOCYTES, LABILE, METABOLISM, OXOVANADATES, VANADATE},
	isbn = {0162-0134},
	url = {<Go to ISI>://A1997YA96300005},
	author = {Yuen, V. G. and Caravan, P. and Gelmini, L. and Glover, N. and McNeill, J. H. and Setyawati, I. A. and Zhou, Y. and Orvig, Chris}
}
@article {3265,
	title = {Reaction chemistry of BMOV, bis(maltolato)oxovanadium(IV) - A potent insulin mimetic agent},
	journal = {Journal of the American Chemical Society},
	volume = {117},
	number = {51},
	year = {1995},
	note = {ISI Document Delivery No.: TM483Times Cited: 165Cited Reference Count: 66},
	month = {Dec},
	pages = {12759-12770},
	type = {Article},
	abstract = {{The reaction chemistry of the potent insulin-mimetic agent bis(maltolato)oxovanadium(IV) (abbreviated BMOV or VO(ma)(2)) is reported. VO(ma)(2) (log K-1 = 8.80(2), log K-2 = 7.51(2), log beta(2) = 16.31(3)) has a rich coordination chemistry, forming a number of V(IV) and V(V) derivatives. In aqueous solution it is slowly oxidized by molecular oxygen to [VO2(ma)(2)](-) (log K-1 = 7.5(1), log K-2 = 6.2(1), log beta(2) = 13.7(1)); in alcohols a variety of V(V) analogs VO(OR)(ma)(2) (R = CH3, C2H5, i-C3H7) are formed by aerial oxidation. All these vanadate complexes can be interconverted by reaction with the appropriate alcohol or water. In addition, the six-coordinate V(IV) pyridine adduct VO(ma)(2)py can be formed and this undergoes oxidation to V(V) complexes much more slowly, demonstrating that a vacant coordinate site is required for the coordination of O-2 to VO(ma)(2) before inner-sphere oxidation can take place. V-51 NMR and electrochemistry have been studied as a function of pH; a complete study of the aqueous chemistry of VO(ma)(2) and [VO2(ma)(2)](-) has been undertaken because the oral activity of VO(ma)(2) as an insulin-mimetic may be related to the chemical properties of the two compounds in water. Oral gavage studies in STZ-diabetic rats have been performed which showed that the intact complex is required for activity and that the presence of a biologically compatible reducing agent, ascorbic acid, neither interferes with nor augments the insulin-mimetic effect of VO(ma)(2). The X-ray structures of VO(ma)(2) and the cis-VO2 compound K[VO2(ma)(2)]. H2O have been determined; crystals of VO(ma)(2)[BMOV] are monoclinic, P2(1)/n},
	keywords = {aluminum, DIABETIC RATS, DISSOCIATION, GLUCOSE, ISOLATED RAT ADIPOCYTES, MALTOL COMPLEX, METABOLISM, METAL CHELATE COMPLEXES, RECEPTOR KINASE, VANADYL COMPLEXES},
	isbn = {0002-7863},
	url = {<Go to ISI>://A1995TM48300013},
	author = {Caravan, P. and Gelmini, L. and Glover, N. and Herring, F. G. and Li, H. L. and McNeill, J. H. and Rettig, S. J. and Setyawati, I. A. and Shuter, E. and Sun, Y. and Tracey, A. S. and Yuen, V. G. and Orvig, Chris}
}
@article {3265,
	title = {Reaction chemistry of BMOV, bis(maltolato)oxovanadium(IV) - A potent insulin mimetic agent},
	journal = {Journal of the American Chemical Society},
	volume = {117},
	number = {51},
	year = {1995},
	note = {ISI Document Delivery No.: TM483Times Cited: 165Cited Reference Count: 66},
	month = {Dec},
	pages = {12759-12770},
	type = {Article},
	abstract = {{The reaction chemistry of the potent insulin-mimetic agent bis(maltolato)oxovanadium(IV) (abbreviated BMOV or VO(ma)(2)) is reported. VO(ma)(2) (log K-1 = 8.80(2), log K-2 = 7.51(2), log beta(2) = 16.31(3)) has a rich coordination chemistry, forming a number of V(IV) and V(V) derivatives. In aqueous solution it is slowly oxidized by molecular oxygen to [VO2(ma)(2)](-) (log K-1 = 7.5(1), log K-2 = 6.2(1), log beta(2) = 13.7(1)); in alcohols a variety of V(V) analogs VO(OR)(ma)(2) (R = CH3, C2H5, i-C3H7) are formed by aerial oxidation. All these vanadate complexes can be interconverted by reaction with the appropriate alcohol or water. In addition, the six-coordinate V(IV) pyridine adduct VO(ma)(2)py can be formed and this undergoes oxidation to V(V) complexes much more slowly, demonstrating that a vacant coordinate site is required for the coordination of O-2 to VO(ma)(2) before inner-sphere oxidation can take place. V-51 NMR and electrochemistry have been studied as a function of pH; a complete study of the aqueous chemistry of VO(ma)(2) and [VO2(ma)(2)](-) has been undertaken because the oral activity of VO(ma)(2) as an insulin-mimetic may be related to the chemical properties of the two compounds in water. Oral gavage studies in STZ-diabetic rats have been performed which showed that the intact complex is required for activity and that the presence of a biologically compatible reducing agent, ascorbic acid, neither interferes with nor augments the insulin-mimetic effect of VO(ma)(2). The X-ray structures of VO(ma)(2) and the cis-VO2 compound K[VO2(ma)(2)]. H2O have been determined; crystals of VO(ma)(2)[BMOV] are monoclinic, P2(1)/n},
	keywords = {aluminum, DIABETIC RATS, DISSOCIATION, GLUCOSE, ISOLATED RAT ADIPOCYTES, MALTOL COMPLEX, METABOLISM, METAL CHELATE COMPLEXES, RECEPTOR KINASE, VANADYL COMPLEXES},
	isbn = {0002-7863},
	url = {<Go to ISI>://A1995TM48300013},
	author = {Caravan, P. and Gelmini, L. and Glover, N. and Herring, F. G. and Li, H. L. and McNeill, J. H. and Rettig, S. J. and Setyawati, I. A. and Shuter, E. and Sun, Y. and Tracey, A. S. and Yuen, V. G. and Orvig, Chris}
}
