@article {4903,
	title = {Improved synthesis of isogranulatimide, a G2 checkpoint inhibitor. Syntheses of didemnimide C, isodidemnimide A, neodidemnimide A, 17-methylgranulatimide, and isogranulatimides A-C},
	journal = {Journal of Organic Chemistry},
	volume = {65},
	number = {2},
	year = {2000},
	note = {ISI Document Delivery No.: 276YFTimes Cited: 44Cited Reference Count: 35},
	month = {Jan},
	pages = {530-535},
	type = {Article},
	abstract = {A concise, improved synthesis of isogranulatimide (6), a naturally occurring substance with G2 checkpoint inhibition activity, is described. Also reported are the syntheses of didemnimide C (18), isodidemnimide A (24), neodidemnimide A (36), 17-methylgranulatimide (9), and isogranulatimides A (10), B (11), and C (12). Compounds 9-12, congeners of isogranulatimide (6), are now available for biological evaluation.},
	keywords = {BHK CELLS, CAFFEINE, CANCER, CELL-CYCLE CHECKPOINTS, CISPLATIN, DERIVATIVES, DNA-REPLICATION, ENHANCEMENT, IMIDAZOLES, RADIOSENSITIZATION},
	isbn = {0022-3263},
	url = {<Go to ISI>://000084905400039},
	author = {Piers, E. and Britton, R. and Andersen, R. J.}
}
@article {4194,
	title = {Granulatimide and isogranulatimide, aromatic alkaloids with G2 checkpoint inhibition activity isolated from the Brazilian ascidian Didemnum granulatum: Structure elucidation and synthesis},
	journal = {Journal of Organic Chemistry},
	volume = {63},
	number = {26},
	year = {1998},
	note = {ISI Document Delivery No.: 153LPTimes Cited: 72Cited Reference Count: 34},
	month = {Dec},
	pages = {9850-9856},
	type = {Article},
	abstract = {Crude methanol ex-tracts of the ascidian Didemum granulatum collected in Brazil showed activity in a new screen for G2 cell cycle checkpoint inhibitors. Bioassay-guided fractionation of the extract yielded the known alkaloids didemnimides A (1) and D (2), the new alkaloid didemnimide E (3), and a new G2 checkpoint inhibitor. Two candidate structures for the inhibitor, named granulatimide (4) and isogranulatimide (5), have been prepared via a short and efficient biomimetic synthesis involving the photolysis of didemnimide A (1). The synthesis revealed that the correct structure for the naturally occurring G2 checkpoint inhibitor is isogranulatimide (5). Granulatimide (4), the other candidate structure, was also found to be a G2 checkpoint inhibitor, and it was subsequently detected in chromatographic fractions associated with purification of D. granulatum alkaloids. Granulatimide (4) and isogranulatimide (5) represent the first examples of a new class of G2 specific cell cycle checkpoint inhibitors and the first ones identified through a rational screening program.},
	keywords = {BHK CELLS, CAFFEINE, CELL-CYCLE CHECKPOINTS, DNA-REPLICATION, HELA-CELLS, INDUCED G(2) DELAY, mitosis, PROTEIN-KINASE, RADIOSENSITIZATION, STAUROSPORINE},
	isbn = {0022-3263},
	url = {<Go to ISI>://000077834800044},
	author = {Berlinck, R. G. S. and Britton, R. and Piers, E. and Lim, L. and Roberge, M. and da Rocha, R. M. and Andersen, R. J.}
}
