@article {DI2021100753,
	title = {Evaluation of La(XT), a novel lanthanide compound, in an OVX rat model of osteoporosis},
	journal = {Bone Reports},
	volume = {14},
	year = {2021},
	month = {02/2021},
	pages = {100753},
	abstract = {<p>Purpose The purpose of this study was to evaluate the efficacy and toxicity of a novel lanthanum compound, La(XT), in an ovariectomized (OVX) rat model of osteoporosis. Methods Twenty-four ovariectomized female Sprague Dawley rats were divided into 3 groups receiving a research diet with/without treatment compounds (alendronate: 3\&nbsp;mg/kg; La(XT) 100\&nbsp;mg/kg) for three months. At the time of sacrifice, the kidney, liver, brain, lung and spleen were collected for histological examination. The trabecular bone structure of the tibiae was evaluated using micro-CT and a three-point metaphyseal mechanical test was used to evaluate bone failure load and stiffness. Results No significant differences were noted in plasma levels of calcium, phosphorus, creatinine, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) between the La(XT) treatment compared to the non-treated OVX group. Alendronate-treated animals (positive control) showed higher BV/TV, Tb.N and lower Tb.Th and Tb.Sp when compared to the non-treated OVX group. Mechanical analysis indicated that stiffness was higher in the alendronate (32.88\%, p\&nbsp;=\&nbsp;0.04) when compared to the non-treated OVX group. Failure load did not differ among the groups. Conclusions No kidney or liver toxicities of La(XT) treatments were found during the three-month study. The absence of liver and kidney toxicity with drug treatment for 3\&nbsp;months, as well as the increased trabecular bone stiffness are encouraging for the pursuit of further studies with La(XT) for a longer duration of time.</p>},
	keywords = {La(XT), LANTHANUM, osteoporosis, OVX, TOXICITY},
	issn = {2352-1872},
	doi = {https://doi.org/10.1016/j.bonr.2021.100753},
	url = {https://www.sciencedirect.com/science/article/pii/S2352187221000085},
	author = {Yunyun Di and Ellen K. Wasan and Jacqueline Cawthray and Jaweria Syeda and Munawar Ali and David M.L. Cooper and Ahmad Al-Dissi and Nima Ashjaee and Wubin Cheng and James Johnston and David M. Weekes and Thomas I. Kostelnik and Chris Orvig and Kishor M. Wasan}
}
@article {28134,
	title = {A preliminary study on the effects of lanthanum (III) on plant vitronectin-like protein and its toxicological basis},
	journal = {Ecotoxicol Environ Saf},
	volume = {145},
	year = {2017},
	month = {11/2017},
	pages = {227-234},
	chapter = {227-234},
	abstract = {<p>Vitronectin-like protein (VN) is widely found outside plant plasma membranes. The VN molecular surface contains a large number of active groups that combine strongly with rare earth elements (REEs), which means that VN is a preferential binding target for REEs exhibiting their toxic effects, but the toxicological mechanism remains unknown. This study used transmission electron microscopy, circular dichroism, fluorescence spectrometry, ultraviolet-visible spectroscopy, X-ray photoelectron spectroscopy, and calculational chemistry (homology modeling, molecular dynamics simulation and quantum chemical calculation) to preliminarily investigate the effect of lanthanum [La(III)] as an REE, on the structure of VN and its toxicological mechanism. The results showed that low-concentration La(III) could cause micro-interference to the VN molecular structure through weak interactions, such as electrostatic attraction. High-concentration La(III) formed stable complexes with VN, which changed the average binding energy and electron cloud density of VN, loosened the molecular structure and increased the disorder of VN molecule. The results of building a 3D model of VN and simulating the interaction between La(III) and VN using calculational chemistry showed that La(H2O)73+\&nbsp;in solution could coordinately bind to the carboxyl-/carbonyl-O groups in the negatively charged areas on the VN molecular surface. Furthermore, one or more strong H-bonds were formed to enhance the stability of the La(H2O)73+-VN complexes. In summary, low La(III) concentrations could cause micro-interference to the VN molecular structure, whereas high La(III) concentrations could coordinately bind to VN to form stable La-VN complexes, which destroyed the molecular structure of VN; thus the toxicological basis by which La(III) exhibits its toxic effects is its binding to VN.</p>},
	keywords = {LANTHANUM, Rare earth elements, Toxic mechanism, Vitronectin-like protein},
	doi = {10.1016/j.ecoenv.2017.07.039},
	author = {Wang, L and He, J and Yang, Q and Li, X and Wei, H and Chen, DDY and Huang, X}
}
@article {7232,
	title = {MONO(AMIDO-DIPHOSPHINE) COMPLEXES OF YTTRIUM - SYNTHESIS AND X-RAY CRYSTAL-STRUCTURE OF (Y(ETA-3-C3H5)[N(SIME2CH2PME2)2])2(MU-CL)2},
	journal = {Organometallics},
	volume = {11},
	number = {9},
	year = {1992},
	note = {ISI Document Delivery No.: JN066Times Cited: 46Cited Reference Count: 7},
	month = {Sep},
	pages = {2967-2969},
	type = {Note},
	abstract = {The reaction of allylmagnesium chloride with the bis(amido-phosphine) complex YCl[N(SiMe2CH2PMe2)2]2 (1) results in displacement of one of the tridentate ligands rather than simple metathesis of the chloride to generate the new complex {Y(eta-3-C3H5)[N(SiMe2CH2PMe2)2]}2(mu-Cl)2. Careful product analysis showed that the identity of the magnesium byproduct was in fact the bis(amide) derivative Mg[N(SiMe2CH2PMe2)2]2; improved procedures utilize the diallylmagnesium compound Mg(C3H5)2.(dioxane), which obviates the production of MgCl2. Attempts to introduce hydrocarbyl groups on the Mono(ligand) derivative YCl2[N(SiMe2CH2PMe2)2] by control Of stoichiometry have so far failed, with the exception of the formation of the bis(allyl) derivative [Y(eta-3-C3H5)2[N(SiMe2CH2PMe2)2] by the reaction with Mg(C3H5)2.(dioxane); this bis(allyl) derivative acts as a catalyst precursor for the polymerization of ethylene.},
	keywords = {FLUXIONAL BEHAVIOR, LANTHANUM, LUTETIUM, PHOSPHINE COMPLEXES},
	isbn = {0276-7333},
	url = {<Go to ISI>://A1992JN06600006},
	author = {Fryzuk,Michael D. and Haddad, T. S. and Rettig, S. J.}
}
