@article {642,
	title = {Anticancer agents from unique natural products sources},
	journal = {Pharmaceutical Biology},
	volume = {41},
	year = {2003},
	note = {ISI Document Delivery No.: 877RKTimes Cited: 5Cited Reference Count: 8344th Annual Meeting of the American-Society-of-PharmacognosyJUL 12-16, 2003Chapel Hill, NCAmer Soc PharmacognosySuppl. S},
	pages = {15-38},
	type = {Proceedings Paper},
	abstract = {The National Cooperative Natural Products Drug Discovery Group (NCNPDDG) "Anticancer Agents from Unique Natural Products Sources, CA 67786" was first awarded in September 1995. The goal of the project is to discover and develop novel anticancer agents from a variety of natural products sources. The key accomplishments of this NCDDG which will be highlighted in this manuscript include: Development of tools to probe fungi for the production of novel natural products by DNA-based probes. Discovery that the majority of these fungi can produce natural products via nonribosomal peptide synthetases, polyketide synthases, or both - a much larger percentage than current culturing techniques reveal. Identification of the MDR-selective cytotoxic agent austocystin D, and use of a novel yeast deletion strain approach to help identify its molecular target(s). Identification of hemiasterlin and other naturally occurring analogs as potent antimitotic agents with excellent in vivo activity against human solid tumors in mouse models. Development of a total synthesis of hemiasterlin. The utilization of this methodology to provide the first SAR for the hemiasterlin family of antimitotic agents and to identify the synthetic analog HTI-286, which is being examined in clinical trials as an anticancer agent. To provided technology transfer, educational opportunities and compensation to countries of origin for collection and study of their natural product resources. This NCNPDDG program has provided funding to research programs at the University of the Philippines, The University of the South Pacific in the Fiji Islands, Colombo University in Sri Lanka, the Instituto de Quimica de Sao Carlos, Universidade de Sao Paulo, Brazil, and the University of Papua New Guinea.},
	keywords = {ACTIVATED PROTEIN-KINASE, antitumor agents, austocystins, CYCLIN-DEPENDENT KINASES, CYTOTOXIC PEPTIDES, fungi, GROWTH-FACTOR RECEPTOR, hemiasterlins, IN-VIVO, LINKED-IMMUNOSORBENT-ASSAY, MARINE, MICROORGANISMS, MULTIDRUG-RESISTANCE, natural products, NCDDG, sponges, TRIPEPTIDE HEMIASTERLIN, TUMOR-CELL LINES, TYROSINE KINASE},
	isbn = {1388-0209},
	url = {<Go to ISI>://000225587500004},
	author = {Ireland, C. M. and Aalbersberg, W. and Andersen, R. J. and Ayral-Kaloustian, S. and Berlinck, R. G. S. and Bernan, V. and Carter, G. and Churchill, A. C. L. and Clardy, J. and Concepcion, G. P. and De Silva, E. D. and Discafani, C. and Fojo, T. and Frost, P. and Gibson, D. and Greenberger, L. M. and Greenstein, M. and Harper, M. K. and Mallon, R. and Loganzo, F. and Nunes, M. and Poruchynsky, M. S. and Zask, A.}
}
@article {664,
	title = {Demethylation of methylarsenic species by Mycobacterium neoaurum},
	journal = {Applied Organometallic Chemistry},
	volume = {17},
	number = {11},
	year = {2003},
	note = {ISI Document Delivery No.: 737CBTimes Cited: 6Cited Reference Count: 26},
	month = {Nov},
	pages = {831-834},
	type = {Article},
	abstract = {Mycobacterium neoaurum demethylates both methylarsonic acid and methylarsonous acid to mixtures of arsenate and arsenite. After 28 days of incubation, the yields of inorganic arsenic were 27\% from arsenate and 43\% from arsenite. A time study of the demethylation of methylarsonic acid by M. neoaurum showed that demethylation occurs rapidly during the growth and stationary phases of the bacterium, and indicates that MMA(V) is reductively demethylated to arsenite. Copyright (C) 2003 John Wiley Sons, Ltd.},
	keywords = {ACID, arsenic, ARSENICALS, ARSINE, CANDIDA-HUMICOLA, DEGRADATION, demethylation, METABOLITES, methylarsonic acid, methylarsonous acid, MICROORGANISMS, Mycobacterium neoaurum, RATS, REDUCTION, SOIL},
	isbn = {0268-2605},
	url = {<Go to ISI>://000186209800002},
	author = {Lehr, C. R. and Polishchuk, E. and Radoja, U. and Cullen, W. R.}
}
@article {658,
	title = {Reductive dechlorination of weathered Aroclor 1260 during anaerobic biotreatment of Arctic soils},
	journal = {Canadian Journal of Microbiology},
	volume = {49},
	number = {1},
	year = {2003},
	note = {ISI Document Delivery No.: 654TDTimes Cited: 3Cited Reference Count: 23},
	month = {Jan},
	pages = {9-14},
	type = {Article},
	abstract = {We investigated the microbial reductive dechlorination of both weathered (aged) and nonweathered (freshly added) Aroclor 1260 in aerobic soil from Resolution Island, Nunavut, Canada. Initial polychlorinated biphenyl (PCB) concentrations were 106 and 100 ppm, respectively. The aerobic soil samples were inoculated with anaerobic sediment, incubated at 30degreesC until methanogenic, inoculated with a dechlorinating enrichment culture, and incubated a further 8 weeks. The average number of chlorine substituents per biphenyl molecule was biologically reduced from 6.6 to 5.1 and from 6.2 to 4.5 for weathered and nonweathered Aroclor 1260, respectively. Removal of hexa- and heptachlorobiphenyls (CBs), the major homolog groups present, was significantly greater for nonweathered than for weathered Aroclor 1260. Formation of dechlorination products, primarily 2,2{\textquoteright},4,4{\textquoteright}- and 2,2{\textquoteright},4,6{\textquoteright}-tetraCBs, was also significantly greater for nonweathered than for weathered Aroclor 1260. We additionally compared the dechlorination at 21degreesC of weathered Aroclor 1260 in soils from Resolution Island and Saglek, Labrador, Canada. The average number of chlorine substituents per biphenyl molecule was biologically reduced from 6.7 to 5.1 and from 6.5 to 4.6, respectively. This study demonstrated the potential for bioremediation of aerobic soil contaminated with Aroclor 1260 and showed that weathering may limit such treatment to an extent variable among different soils.},
	keywords = {BIODEGRADATION, bioremediation, META, MICROBIAL DECHLORINATION, MICROORGANISMS, PCB, PCBS, polychlorinated biphenyl, POLYCHLORINATED-BIPHENYLS, SEDIMENTS},
	isbn = {0008-4166},
	url = {<Go to ISI>://000181511400002},
	author = {Kuipers, B. and Cullen, W. R. and Mohn, W. W.}
}
@article {337,
	title = {Tupuseleiamides and basiliskamides, new acyldipeptides and antifungal polyketides produced in culture by a Bacillus laterosporus isolate obtained from a tropical marine habitat},
	journal = {Journal of Natural Products},
	volume = {65},
	number = {10},
	year = {2002},
	note = {ISI Document Delivery No.: 609YZTimes Cited: 13Cited Reference Count: 14},
	month = {Oct},
	pages = {1447-1451},
	type = {Article},
	abstract = {Laboratory cultures of PNG 276, a Bacillus laterosporus isolate obtained from coastal waters off Papua New Guinea, have been shown to produce the novel metabolites basiliskamide A (1), basiliskamide B (2), tupuseleiamide A (3), and tupusleiamide B (4). The structures of I to 4 were elucidated by analysis of spectroscopic data and chemical degradation. Basiliskamides A (1) and B (g) show potent in vitro anti-Candida, activity.},
	keywords = {ANTIBIOTIC-RESISTANCE, BACTERIUM, MICROORGANISMS, NATURAL-PRODUCTS, STEREOCHEMISTRY, YM-47522},
	isbn = {0163-3864},
	url = {<Go to ISI>://000178935100011},
	author = {Barsby, T. and Kelly, M. T. and Andersen, R. J.}
}
@article {5000,
	title = {Antimony biomethylation by the wood rotting fungus Phaeolus schweinitzii},
	journal = {Applied Organometallic Chemistry},
	volume = {15},
	number = {6},
	year = {2001},
	note = {ISI Document Delivery No.: 435TUTimes Cited: 18Cited Reference Count: 27},
	month = {Jun},
	pages = {473-480},
	type = {Article},
	abstract = {The wood rotting fungus, Phaeolus schweinitzii, efficiently transforms the antimony(III) compounds potassium antimony tartrate and antimony trioxide to nonvolatile dimethylantimony and trimethylantimony species, The organoantimony species were detected in potato dextrose broth media samples by using hydride generation-gas chromatography-atomic absorption spectroscopy (HG-GC-AAS). The average concentrations of trimethylantimony species after 40 days incubation with potassium antimony tartrate were approximately 35 mug, 155 mug and 520 mug Sb/l, for substrate concentrations of 10 mg, 100 mg and 1000 mg Sb/l respectively. Thus, the maximum yield of trimethylantimony species was approximately 0.4\%, When antimony trioxide (saturated solution, 4 mg Sb/l) was used as a substrate, the average concentration of trimethylantimony species was 150 mug Sb/l after 40 days. The HG-GC-AAS response for the dimethylantimony species was less than that for the trimethylantimony species; however, quantification was not possible because of the lack of an appropriate standard. In comparison, cultures of P, schweinitzii incubated with 1 mg As/I as sodium arsenite contained approximately 200 mug As/I as trimethylarsenic species, i.e. 20\% yield, Biomethylation of antimony(V) was inefficient: cultures contained only 3 mug Sb/l as trimethylantimony species after incubation with 100 mg Sb/l as potassium hexahydroxyantimonate, No organoantimony species were detected in control cultures that contained only medium and inorganic antimony compounds. The identities of the organoantimony species were confirmed by using CC-Mass Spectrometry, Copyright (C) 2001 John Wiley \& Sons, Ltd.},
	keywords = {ABSORPTION SPECTROSCOPY, CHROMATOGRAPHY MASS-SPECTROMETRY, chromatography-atomic, CONFIRMATION, CULTURES, dimethylantimony, GENERATION, GROWTH, HUMICOLA, hydride generation-gas, infant death syndrome (SIDS), INFANT-DEATH-SYNDROME, MICROORGANISMS, Phaeolus schweinitzii, SCOPULARIOPSIS-BREVICAULIS, SPECIATION, sudden, trimethylantimony},
	isbn = {0268-2605},
	url = {<Go to ISI>://000168897900005},
	author = {Andrewes, P. and Cullen, W. R. and Polishchuk, E. and Reimer, K. J.}
}
@article {4719,
	title = {Arsenic and antimony biomethylation by Scopulariopsis brevicaulis: Interaction of arsenic and antimony compounds},
	journal = {Environmental Science \& Technology},
	volume = {34},
	number = {11},
	year = {2000},
	note = {ISI Document Delivery No.: 320GXTimes Cited: 21Cited Reference Count: 26},
	month = {Jun},
	pages = {2249-2253},
	type = {Article},
	abstract = {The biomethylation of arsenic by the filamentous fungus Scopulariopsis brevicaulis is well documented, and the biomethylation of antimony by this fungus was recently established. However, in all the previous studies each metalloid was studied in isolation. Arsenic and antimony are often associated in the environment, and so an understanding of interactions between these elements is necessary. To this end, S. brevicaulis was grown in media containing mixtures of arsenic and antimony compounds in various proportions, and the principle nonvolatile biomethylation products (trimethylantimony and trimethylarsenic species) in the medium were quantified by using HG-GC-AAS. It was found that the yield of trimethylantimony compounds, obtained from the biomethylation of potassium antimony tartrate, was increased in the presence of sodium arsenite. The production of trimethylarsenic species from sodium arsenite was significantly inhibited in the presence of antimony (either as potassium antimony tartrate or antimony trioxide) at antimony concentrations too low to inhibit growth. This is although arsenic(III), in the absence of antimony, is much more readily biomethylated. That is 1.2-5.3\% of added arsenic is biomethylated by S. brevicaulis whereas only 0.0006-0.008\% of added antimony(III) is biomethylated over 1 month. Potassium hexahydroxyantimonate had no effect on arsenic biomethylation. The addition of potassium tartrate to cultures did not inhibit arsenic biomethylation. The biomethylation of sodium arsenate was not inhibited as much by antimony compounds. The inhibitory effect of antimony was found to be a function of the ratio of antimony to arsenic rather than the absolute amount of antimony.},
	keywords = {CONFIRMATION, CULTURES, HUMICOLA, HYDRIDE GENERATION, INFANT-DEATH-SYNDROME, INORGANIC ANTIMONY, MICROORGANISMS, RELEVANCE, SPECIATION, SPECTROMETRY},
	isbn = {0013-936X},
	url = {<Go to ISI>://000087394400040},
	author = {Andrewes, P. and Cullen, W. R. and Polishchuk, E.}
}
@article {3004,
	title = {DEGRADATION OF PHENANTHRENE AND PYRENE BY MICROORGANISMS ISOLATED FROM MARINE SEDIMENT AND SEAWATER},
	journal = {Science of the Total Environment},
	volume = {156},
	number = {1},
	year = {1994},
	note = {ISI Document Delivery No.: PJ991Times Cited: 18Cited Reference Count: 40},
	month = {Nov},
	pages = {27-37},
	type = {Article},
	abstract = {Microorganisms which are able to degrade phenanthrene and pyrene were isolated from both seawater and sediment samples collected from a polycyclic aromatic hydrocarbon (PAH) polluted environment, Kitimat Arm, British Columbia, Canada. Four strains from a seawater culture were isolated and examined. No additional PAH induction was necessary in the enrichment process, indicating that these PAH degrading microorganisms are previously exposed to PAHs in the environment under study. Microorganisms enriched with phenanthrene as the sole carbon and energy source also degraded pyrene readily. A metabolite, pyrene cis-4,5-dihydrodiol was observed from pyrene degradation, and this metabolite was further degraded after pyrene was utilized by the microorganisms.},
	keywords = {BIODEGRADATION, bioremediation, CONTAMINATED, DEGRADATION, ENVIRONMENT, ESTUARINE SEDIMENTS, MICROORGANISMS, MINERALIZATION, NAPHTHALENE, PAH, PHENANTHRENE, POLYCYCLIC AROMATIC HYDROCARBON, POLYCYCLIC AROMATIC-HYDROCARBONS, PYRENE, SEAWATER, SEDIMENT, SOIL},
	isbn = {0048-9697},
	url = {<Go to ISI>://A1994PJ99100004},
	author = {Cullen, W. R. and Li, X. F. and Reimer, K. J.}
}
