@article {642,
	title = {Anticancer agents from unique natural products sources},
	journal = {Pharmaceutical Biology},
	volume = {41},
	year = {2003},
	note = {ISI Document Delivery No.: 877RKTimes Cited: 5Cited Reference Count: 8344th Annual Meeting of the American-Society-of-PharmacognosyJUL 12-16, 2003Chapel Hill, NCAmer Soc PharmacognosySuppl. S},
	pages = {15-38},
	type = {Proceedings Paper},
	abstract = {The National Cooperative Natural Products Drug Discovery Group (NCNPDDG) "Anticancer Agents from Unique Natural Products Sources, CA 67786" was first awarded in September 1995. The goal of the project is to discover and develop novel anticancer agents from a variety of natural products sources. The key accomplishments of this NCDDG which will be highlighted in this manuscript include: Development of tools to probe fungi for the production of novel natural products by DNA-based probes. Discovery that the majority of these fungi can produce natural products via nonribosomal peptide synthetases, polyketide synthases, or both - a much larger percentage than current culturing techniques reveal. Identification of the MDR-selective cytotoxic agent austocystin D, and use of a novel yeast deletion strain approach to help identify its molecular target(s). Identification of hemiasterlin and other naturally occurring analogs as potent antimitotic agents with excellent in vivo activity against human solid tumors in mouse models. Development of a total synthesis of hemiasterlin. The utilization of this methodology to provide the first SAR for the hemiasterlin family of antimitotic agents and to identify the synthetic analog HTI-286, which is being examined in clinical trials as an anticancer agent. To provided technology transfer, educational opportunities and compensation to countries of origin for collection and study of their natural product resources. This NCNPDDG program has provided funding to research programs at the University of the Philippines, The University of the South Pacific in the Fiji Islands, Colombo University in Sri Lanka, the Instituto de Quimica de Sao Carlos, Universidade de Sao Paulo, Brazil, and the University of Papua New Guinea.},
	keywords = {ACTIVATED PROTEIN-KINASE, antitumor agents, austocystins, CYCLIN-DEPENDENT KINASES, CYTOTOXIC PEPTIDES, fungi, GROWTH-FACTOR RECEPTOR, hemiasterlins, IN-VIVO, LINKED-IMMUNOSORBENT-ASSAY, MARINE, MICROORGANISMS, MULTIDRUG-RESISTANCE, natural products, NCDDG, sponges, TRIPEPTIDE HEMIASTERLIN, TUMOR-CELL LINES, TYROSINE KINASE},
	isbn = {1388-0209},
	url = {<Go to ISI>://000225587500004},
	author = {Ireland, C. M. and Aalbersberg, W. and Andersen, R. J. and Ayral-Kaloustian, S. and Berlinck, R. G. S. and Bernan, V. and Carter, G. and Churchill, A. C. L. and Clardy, J. and Concepcion, G. P. and De Silva, E. D. and Discafani, C. and Fojo, T. and Frost, P. and Gibson, D. and Greenberger, L. M. and Greenstein, M. and Harper, M. K. and Mallon, R. and Loganzo, F. and Nunes, M. and Poruchynsky, M. S. and Zask, A.}
}
@article {555,
	title = {Absolute configuration of the antiinflamatory sponge natural product contignasterol},
	journal = {Journal of Natural Products},
	volume = {65},
	number = {12},
	year = {2002},
	note = {ISI Document Delivery No.: 631WMTimes Cited: 11Cited Reference Count: 14},
	month = {Dec},
	pages = {1924-1926},
	type = {Article},
	abstract = {Chiral auxiliary NMR analysis with C-22 (R/S)-MPA and (R/S)-MTPA esters has been used to demonstrate that the absolute configuration in the side chain of the antiinflammatory sponge metabolite contignasterol (1) is 22R, 24R.},
	keywords = {HISTAMINE-RELEASE, MARINE, MAST-CELLS, XESTOBERGSTEROL-A, XESTOSPONGIA-BERGQUISTIA},
	isbn = {0163-3864},
	url = {<Go to ISI>://000180190100035},
	author = {Yang, L. and Andersen, R. J.}
}
@article {3405,
	title = {INGENAMINE ALKALOIDS ISOLATED FROM THE SPONGE XESTOSPONGIA INGENS - STRUCTURES AND ABSOLUTE-CONFIGURATIONS},
	journal = {Tetrahedron},
	volume = {51},
	number = {10},
	year = {1995},
	note = {ISI Document Delivery No.: QL657Times Cited: 35Cited Reference Count: 11},
	month = {Mar},
	pages = {2895-2906},
	type = {Article},
	abstract = {Five new minor ingenamine alkaloids have been isolated from extracts of the sponge X. ingens collected in Papua New Guinea. The structures of the new metabolites were solved via spectroscopic analysis. Mosher ester methodology has been used to determine the absolute configurations of ingenamine (1), ingamine A (2) and ingenamine E (11). The results show that the {\textquoteright}ingenamine{\textquoteright} alkaloids isolated from X. ingenr are antipodal to the manzamines.},
	keywords = {MARINE},
	isbn = {0040-4020},
	url = {<Go to ISI>://A1995QL65700005},
	author = {Kong, F. M. and Andersen, R. J.}
}
@article {7079,
	title = {CALLYDIYNE, A NEW DIACETYLENIC HYDROCARBON FROM THE SPONGE CALLYSPONGIA-FLAMMEA},
	journal = {Journal of Natural Products},
	volume = {54},
	number = {5},
	year = {1991},
	note = {ISI Document Delivery No.: GM639Times Cited: 7Cited Reference Count: 2},
	month = {Sep-Oct},
	pages = {1433-1434},
	type = {Note},
	abstract = {Callydiyne [1], a new symmetrical diacetylenic hydrocarbon, has been isolated from the marine sponge Callyspongia flammea.},
	keywords = {MARINE},
	isbn = {0163-3864},
	url = {<Go to ISI>://A1991GM63900039},
	author = {Miao, S. C. and Andersen, R. J.}
}
@article {7088,
	title = {ONCORHYNCOLIDE, A NOVEL METABOLITE OF A BACTERIUM ISOLATED FROM SEAWATER},
	journal = {Tetrahedron Letters},
	volume = {32},
	number = {3},
	year = {1991},
	note = {ISI Document Delivery No.: ET815Times Cited: 11Cited Reference Count: 6},
	month = {Jan},
	pages = {315-318},
	type = {Article},
	abstract = {A novel metabolite, oncorhyncolide (1), has been isolated from liquid shake cultures of the bacterial isolate $\#$157 obtained from seawater. The structure of oncorhyncolide has been elucidated by spectroscopic analysis.},
	keywords = {MARINE},
	isbn = {0040-4039},
	url = {<Go to ISI>://A1991ET81500005},
	author = {Needham, J. and Andersen, R. J. and Kelly, M. T.}
}
