@article {2513,
	title = {Divalent later transition metal complexes of the traditional chinese medicine (TCM) liriodenine: coordination chemistry, cytotoxicity and DNA binding studies},
	journal = {Dalton Transactions},
	number = {48},
	year = {2009},
	note = {ISI Document Delivery No.: 527IETimes Cited: 1Cited Reference Count: 91Liu, Yan-Cheng Chen, Zhen-Feng Liu, Li-Min Peng, Yan Hong, Xue Yang, Bin Liu, Hua-Gang Liang, Hong Orvig, Chris},
	pages = {10813-10823},
	type = {Article},
	abstract = {Liriodenine (L), a natural alkaloid, was isolated as an active component from the anticancer traditional Chinese medicine (TCM), Zanthoxylum nitidum. It reacted with Mn-II, Fe-II, Co-II and Zn-II to afford four metal complexes: [MnCl2(L)(2)] (1), [FeCl2(L)(2)] (2), [Co(L)(2)(H2O)(2)center dot Co(L)(2)(CH3CH2OH)(2)](ClO4)(4) (3), and [Zn-2(L)(2)(mu(2)-Cl)(2)Cl-2] (4), which were characterized by elemental analysis, IR, ESI-MS. Their crystal structures were determined by the single crystal X-ray diffraction method. The in vitro cytotoxicity of L and complexes 1-4 against 10 human tumour cell lines was assayed. Some of these metal-based compounds exhibited enhanced cytotoxicity vs. free L to selected tumour cell lines. The binding properties of L and its complexes 1-4 to ct-DNA were investigated by spectroscopic methods and viscosity measurements. Agarose gel electrophoresis experiments were also carried out to evaluate their unwinding ability towards plasmid DNA and their inhibition towards Topoisomerase I. All the results indicate that complexes 1-4 may bind more intensively to the DNA helix than does L, and intercalative binding for complexes 1-4 and electrostatic interactions for complexes 3-4 to DNA should be considered. For complex 4, covalent binding to DNA may exist. Of special note, all these metal complexes effectively inhibit Topoisomerase I even at low concentration (<= 10 mu M).},
	keywords = {antitumor agents, CISPLATIN, CRYSTAL-STRUCTURE, GEL-ELECTROPHORESIS, INHIBITION, INNOVATIVE COMBINATION, INTERCALATION, PLATINUM ANTICANCER AGENTS, RUTHENIUM(II) COMPLEXES, TOPOISOMERASE-I},
	isbn = {1477-9226},
	url = {<Go to ISI>://000272359900023},
	author = {Liu, Y. C. and Chen, Z. F. and Liu, L. M. and Peng, Y. and Hong, X. and Yang, B. and Liu, H. G. and Liang, H. and Orvig, Chris}
}
@article {642,
	title = {Anticancer agents from unique natural products sources},
	journal = {Pharmaceutical Biology},
	volume = {41},
	year = {2003},
	note = {ISI Document Delivery No.: 877RKTimes Cited: 5Cited Reference Count: 8344th Annual Meeting of the American-Society-of-PharmacognosyJUL 12-16, 2003Chapel Hill, NCAmer Soc PharmacognosySuppl. S},
	pages = {15-38},
	type = {Proceedings Paper},
	abstract = {The National Cooperative Natural Products Drug Discovery Group (NCNPDDG) "Anticancer Agents from Unique Natural Products Sources, CA 67786" was first awarded in September 1995. The goal of the project is to discover and develop novel anticancer agents from a variety of natural products sources. The key accomplishments of this NCDDG which will be highlighted in this manuscript include: Development of tools to probe fungi for the production of novel natural products by DNA-based probes. Discovery that the majority of these fungi can produce natural products via nonribosomal peptide synthetases, polyketide synthases, or both - a much larger percentage than current culturing techniques reveal. Identification of the MDR-selective cytotoxic agent austocystin D, and use of a novel yeast deletion strain approach to help identify its molecular target(s). Identification of hemiasterlin and other naturally occurring analogs as potent antimitotic agents with excellent in vivo activity against human solid tumors in mouse models. Development of a total synthesis of hemiasterlin. The utilization of this methodology to provide the first SAR for the hemiasterlin family of antimitotic agents and to identify the synthetic analog HTI-286, which is being examined in clinical trials as an anticancer agent. To provided technology transfer, educational opportunities and compensation to countries of origin for collection and study of their natural product resources. This NCNPDDG program has provided funding to research programs at the University of the Philippines, The University of the South Pacific in the Fiji Islands, Colombo University in Sri Lanka, the Instituto de Quimica de Sao Carlos, Universidade de Sao Paulo, Brazil, and the University of Papua New Guinea.},
	keywords = {ACTIVATED PROTEIN-KINASE, antitumor agents, austocystins, CYCLIN-DEPENDENT KINASES, CYTOTOXIC PEPTIDES, fungi, GROWTH-FACTOR RECEPTOR, hemiasterlins, IN-VIVO, LINKED-IMMUNOSORBENT-ASSAY, MARINE, MICROORGANISMS, MULTIDRUG-RESISTANCE, natural products, NCDDG, sponges, TRIPEPTIDE HEMIASTERLIN, TUMOR-CELL LINES, TYROSINE KINASE},
	isbn = {1388-0209},
	url = {<Go to ISI>://000225587500004},
	author = {Ireland, C. M. and Aalbersberg, W. and Andersen, R. J. and Ayral-Kaloustian, S. and Berlinck, R. G. S. and Bernan, V. and Carter, G. and Churchill, A. C. L. and Clardy, J. and Concepcion, G. P. and De Silva, E. D. and Discafani, C. and Fojo, T. and Frost, P. and Gibson, D. and Greenberger, L. M. and Greenstein, M. and Harper, M. K. and Mallon, R. and Loganzo, F. and Nunes, M. and Poruchynsky, M. S. and Zask, A.}
}
