@article {701,
	title = {Synthesis and antimitotic/cytotoxic activity of hemiasterlin analogues},
	journal = {Journal of Natural Products},
	volume = {66},
	number = {2},
	year = {2003},
	note = {ISI Document Delivery No.: 652JHTimes Cited: 45Cited Reference Count: 37},
	month = {Feb},
	pages = {183-199},
	type = {Article},
	abstract = {The antimitotic sponge tripeptide hemiasterlin (1) and a number of structural analogues have been synthesized and evaluated in cell-based assays for both cytotoxic and antimitotic activity in order to explore the SAR for this promising anticancer drug lead. One synthetic analogue, SPA110 (8), showed more potent in vitro cytotoxicty and antimitotic activity than the natural product hemiasterlin (1), and consequently it has been subjected to thorough preclinical evaluation and targeted for clinical evaluation. The details of the synthesis of hemiasterlin (1) and the analogues and a discussion of how their biological activities vary with their structures are presented in this paper.},
	keywords = {(-)-HEMIASTERLIN, AGENTS, ALPHA-AMINO-ACIDS, ASYMMETRIC-SYNTHESIS, AZIDATION, CYTOTOXIC PEPTIDES, ELEUTHEROBIN, TRIPEPTIDE, TUBULIN},
	isbn = {0163-3864},
	url = {<Go to ISI>://000181375700005},
	author = {Nieman, J. A. and Coleman, J. E. and Wallace, D. J. and Piers, E. and Lim, L. Y. and Roberge, M. and Andersen, R. J.}
}
@article {3874,
	title = {Total synthesis of (-)-hemiasterlin, a structurally novel tripeptide that exhibits potent cytotoxic activity},
	journal = {Tetrahedron Letters},
	volume = {38},
	number = {3},
	year = {1997},
	note = {ISI Document Delivery No.: WC807Times Cited: 44Cited Reference Count: 16},
	month = {Jan},
	pages = {317-320},
	type = {Article},
	abstract = {The total synthesis of (-)-hemiasterlin (2), a structurally novel, naturally occurring tripeptide that exhibits potent cytotoxic and antimitotic activity against human breast cancer MCF7 cells, is described. Copyright (C) 1996 Elsevier Science Ltd},
	keywords = {ALPHA-AMINO-ACIDS, ASYMMETRIC-SYNTHESIS, AZIDATION, PEPTIDES},
	isbn = {0040-4039},
	url = {<Go to ISI>://A1997WC80700005},
	author = {Andersen, R. J. and Coleman, J. E. and Piers, E. and Wallace, D. J.}
}
