@article {435, title = {Evaluation of tetraphenyl-2,3-dihydroxychlorins as potential photosensitizers}, journal = {Journal of Porphyrins and Phthalocyanines}, volume = {6}, number = {2}, year = {2002}, note = {ISI Document Delivery No.: 595XYTimes Cited: 15Cited Reference Count: 33}, pages = {146-155}, type = {Article}, abstract = {A series of beta,beta-dihydroxychlorins derived from meso-tetraphenylporphyrins (TPPs) have been synthesized. Their in vitro cytotoxicity has been measured and compared to BPDMA (verteporfin). Under the assay conditions BPDMA had an LD50 (lethal dose to kill 50\% of cells) value of 0.007 muM (5 ng/mL). The LD50 values for the TPP derivatives varied from 1.7 x 10(-2) to 9.9 muM depending upon the substituents and their position on the phenyl groups. One example of the dihydroxychlorin prepared from unsubstituted 5,15-diphenylporphyrin was examined and this exhibited an LD50 of 2.4 x 10(-3) muM! Copyright (C) 2002 Society of Porphyrins \& Phthalocyanines.}, keywords = {AGGREGATION, BACTERIOCHLORINS, beta, beta-dihydroxychlorins, BIODISTRIBUTION, chlorins, cytotoxicity, DERIVATIVES, photodynamic, PHOTODYNAMIC THERAPY, PHOTOPHYSICAL PROPERTIES, PHOTOSENSITIZERS, porphyrins, PROTEIN-BINDING, SENSITIZERS, therapy, TUMOR PHOTOSENSITIZERS}, isbn = {1088-4246}, url = {://000178134600008}, author = {Macalpine, J. K. and Boch, R. and Dolphin, D.} } @article {3262, title = {2,3-VIC-DIHYDROXY-MESO-TETRAPHENYLCHLORINS FROM THE OSMIUM-TETROXIDE OXIDATION OF MESO-TETRAPHENYLPORPHYRIN}, journal = {Tetrahedron Letters}, volume = {36}, number = {19}, year = {1995}, note = {ISI Document Delivery No.: QY111Times Cited: 34Cited Reference Count: 25}, month = {May}, pages = {3295-3298}, type = {Article}, abstract = {meso-Tetraphenylporphyrins and meso-tetraphenylmetalloporphyrins were converted into stable 2,3-vic-dihydroxy-meso-tetraphenylchlorins and 2,3-vic-dihydroxy-meso-tetraphenylmetallochlorins by oxidation with stoichiometric amounts of OsO4 and subsequent reduction of the isolable osmate esters. The stable dihydroxychlorins were dehydrated under acid catalysis to yield 2-hydroxy-meso-tetraphenylporphyrins.}, keywords = {BACTERIOCHLORINS, chlorins, EFFICIENT SYNTHESIS, PHOTODYNAMIC THERAPY, porphyrins, TUMOR PHOTOSENSITIZERS}, isbn = {0040-4039}, url = {://A1995QY11100002}, author = {Bruckner, C. and Dolphin, D.} }