@article {435,
	title = {Evaluation of tetraphenyl-2,3-dihydroxychlorins as potential photosensitizers},
	journal = {Journal of Porphyrins and Phthalocyanines},
	volume = {6},
	number = {2},
	year = {2002},
	note = {ISI Document Delivery No.: 595XYTimes Cited: 15Cited Reference Count: 33},
	pages = {146-155},
	type = {Article},
	abstract = {A series of beta,beta-dihydroxychlorins derived from meso-tetraphenylporphyrins (TPPs) have been synthesized. Their in vitro cytotoxicity has been measured and compared to BPDMA (verteporfin). Under the assay conditions BPDMA had an LD50 (lethal dose to kill 50\% of cells) value of 0.007 muM (5 ng/mL). The LD50 values for the TPP derivatives varied from 1.7 x 10(-2) to 9.9 muM depending upon the substituents and their position on the phenyl groups. One example of the dihydroxychlorin prepared from unsubstituted 5,15-diphenylporphyrin was examined and this exhibited an LD50 of 2.4 x 10(-3) muM! Copyright (C) 2002 Society of Porphyrins \& Phthalocyanines.},
	keywords = {AGGREGATION, BACTERIOCHLORINS, beta, beta-dihydroxychlorins, BIODISTRIBUTION, chlorins, cytotoxicity, DERIVATIVES, photodynamic, PHOTODYNAMIC THERAPY, PHOTOPHYSICAL PROPERTIES, PHOTOSENSITIZERS, porphyrins, PROTEIN-BINDING, SENSITIZERS, therapy, TUMOR PHOTOSENSITIZERS},
	isbn = {1088-4246},
	url = {<Go to ISI>://000178134600008},
	author = {Macalpine, J. K. and Boch, R. and Dolphin, D.}
}
@article {3262,
	title = {2,3-VIC-DIHYDROXY-MESO-TETRAPHENYLCHLORINS FROM THE OSMIUM-TETROXIDE OXIDATION OF MESO-TETRAPHENYLPORPHYRIN},
	journal = {Tetrahedron Letters},
	volume = {36},
	number = {19},
	year = {1995},
	note = {ISI Document Delivery No.: QY111Times Cited: 34Cited Reference Count: 25},
	month = {May},
	pages = {3295-3298},
	type = {Article},
	abstract = {meso-Tetraphenylporphyrins and meso-tetraphenylmetalloporphyrins were converted into stable 2,3-vic-dihydroxy-meso-tetraphenylchlorins and 2,3-vic-dihydroxy-meso-tetraphenylmetallochlorins by oxidation with stoichiometric amounts of OsO4 and subsequent reduction of the isolable osmate esters. The stable dihydroxychlorins were dehydrated under acid catalysis to yield 2-hydroxy-meso-tetraphenylporphyrins.},
	keywords = {BACTERIOCHLORINS, chlorins, EFFICIENT SYNTHESIS, PHOTODYNAMIC THERAPY, porphyrins, TUMOR PHOTOSENSITIZERS},
	isbn = {0040-4039},
	url = {<Go to ISI>://A1995QY11100002},
	author = {Bruckner, C. and Dolphin, D.}
}
