@article {435, title = {Evaluation of tetraphenyl-2,3-dihydroxychlorins as potential photosensitizers}, journal = {Journal of Porphyrins and Phthalocyanines}, volume = {6}, number = {2}, year = {2002}, note = {ISI Document Delivery No.: 595XYTimes Cited: 15Cited Reference Count: 33}, pages = {146-155}, type = {Article}, abstract = {A series of beta,beta-dihydroxychlorins derived from meso-tetraphenylporphyrins (TPPs) have been synthesized. Their in vitro cytotoxicity has been measured and compared to BPDMA (verteporfin). Under the assay conditions BPDMA had an LD50 (lethal dose to kill 50\% of cells) value of 0.007 muM (5 ng/mL). The LD50 values for the TPP derivatives varied from 1.7 x 10(-2) to 9.9 muM depending upon the substituents and their position on the phenyl groups. One example of the dihydroxychlorin prepared from unsubstituted 5,15-diphenylporphyrin was examined and this exhibited an LD50 of 2.4 x 10(-3) muM! Copyright (C) 2002 Society of Porphyrins \& Phthalocyanines.}, keywords = {AGGREGATION, BACTERIOCHLORINS, beta, beta-dihydroxychlorins, BIODISTRIBUTION, chlorins, cytotoxicity, DERIVATIVES, photodynamic, PHOTODYNAMIC THERAPY, PHOTOPHYSICAL PROPERTIES, PHOTOSENSITIZERS, porphyrins, PROTEIN-BINDING, SENSITIZERS, therapy, TUMOR PHOTOSENSITIZERS}, isbn = {1088-4246}, url = {://000178134600008}, author = {Macalpine, J. K. and Boch, R. and Dolphin, D.} }