@article {477,
	title = {Chiral separation of benzoporphyrin derivative mono- and diacids by laser induced fluorescence-capillary electrophoresis},
	journal = {Electrophoresis},
	volume = {23},
	number = {1},
	year = {2002},
	note = {ISI Document Delivery No.: 513ZATimes Cited: 9Cited Reference Count: 42},
	month = {Jan},
	pages = {93-101},
	type = {Article},
	abstract = {A method for the separation of benzoporphyrin derivative mono- and diacid (BPDMA, BPDDA) enantiomers; by laser induced fluorescence-capillary electrophoresis (LIF-CE) has been developed. By using 300 mm borate buffer, pH 9.2, 25 mm sodium cholate and 10\% acetronitrile as electrolyte, +10 kV electrokinetic sampling injection of 2 s and an applied +20 kV voltage across the ends of a 37 cm capillary (30 cm to the detector, 50 mum ID), all six BPD stereoisomers; were baseline-separated within 20 min. Formation constants, free electrophoretic and complexation mobilities with borate and cholate were determined based on dynamic complexation capillary electrophoresis theory. The BPD enantiomers can be quantitatively determined in the range of 10(-2)-10(-5) mg mL(-1). The correlation coefficients (r(2)) of the least-squares linear regression analysis of the BPD enantiomers are in the range of 0.9914-0.9997. Their limits of detection are 2.18-3.5 x 10(-3) mg mL(-1). The relative standard deviations for the separation were 2.90-4.64\% (n = 10). In comparison with high-performance liquid chromatography (HPLC), CE has better resolution and efficiency. This separation method was successfully applied to the BPD enantiomers obtained from a matrix of bovine serum and from liposomally formulated material as well as from studies with rat, dog and human microsomes.},
	keywords = {benzoporphyrin derivative mono- and diacids, BORATE COMPLEXATION, capillary electrophoresis, DYNAMIC COMPLEXATION MODEL, MIGRATION BEHAVIOR, PERFORMANCE LIQUID-CHROMATOGRAPHY, PHOTODYNAMIC THERAPY, PHOTOSENSITIZER, porphyrins, QUANTITATIVE DESCRIPTION, SYSTEM, TUMOR, ZONE ELECTROPHORESIS},
	isbn = {0173-0835},
	url = {<Go to ISI>://000173410100014},
	author = {Peng, X. J. and Sternberg, E. and Dolphin, D.}
}
@article {4610,
	title = {The metabolites of dietary chlorophylls},
	journal = {Phytochemistry},
	volume = {50},
	number = {2},
	year = {1999},
	note = {ISI Document Delivery No.: 160EBTimes Cited: 15Cited Reference Count: 70},
	month = {Jan},
	pages = {195-202},
	type = {Review},
	abstract = {Chlorophylls, the green pigments responsible for photosynthesis in plants, algae and bacteria, are also part of the daily diet of herbivorous feeders. Numerous metabolic derivatives of the major green pigment, chlorophyll-a, have been found in a wide variety of organisms during the last decade. Studies of these metabolites show that some are antioxidants or cellular signaling mediators in vivo. The metabolites of bacteriochlorophylls-c and d, recently found in the deep-sea dragon fish, Malacosteus niger, function as a visual photosensitizer, enabling the fish to seek their prey in {\textquoteright}the dark{\textquoteright}. Discovery of these metabolites as well as their interesting biological functions raises questions as to the roles of chlorophyll derivatives in the chemical ecology of herbivorous life forms. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.},
	keywords = {antioxidant, AUTOXIDATION, cell signaling, CHLORIN, CHLOROPHYLL, DERIVATIVES, DIET, ESTERS, MARINE ORGANISMS, METABOLISM, PHOTOSENSITIZER, PI-CATION RADICALS, porphyrins, PRODUCTS, RUDITAPES-PHILIPPINARUM, TUNICHLORIN},
	isbn = {0031-9422},
	url = {<Go to ISI>://000078216500001},
	author = {Ma, L. F. and Dolphin, D.}
}
@article {4089,
	title = {Application of long-circulating liposomes to cancer photodynamic therapy},
	journal = {Biological \& Pharmaceutical Bulletin},
	volume = {20},
	number = {6},
	year = {1997},
	note = {ISI Document Delivery No.: XG547Times Cited: 26Cited Reference Count: 30},
	month = {Jun},
	pages = {670-673},
	type = {Article},
	abstract = {Photodynamic therapy (PDT) as a cancer treatment is notable for its quite low side effects in comparison with those of chemotherapy and radiotherapy. However, the accumulation of porphyrin derivatives used in PDT into tumor tissues is rather low. Since long-circulating liposomes are known to accumulate passively into tumor tissues, we liposomalized a porphyrin derivative, benzoporphyrin derivative monoacid ring A (BPD-MA), and used these liposomes to investigate the usefulness of PDT for tumor-bearing mice. BPD-MA was liposomalized into glucuronate-modified liposomes, which are known to be long-circulating. These liposomes were injected i.v. into Balb/c mice bearing Meth A sarcoma, and tumor regression and survival time were monitored after irradiation with laser light. Tumor regression and complete curing of tumor (80\% cure rate by the treatment with 6 mg/kg BPD-R?IA) were observed when long circulating liposomalized BPD-MA was injected and laser-irradiated. In contrast, only a 20\% cure rate was obtained when the animals were treated with BPD-MA solution or BPD-MA entrapped in conventional liposomes. These results suggest that a long-circulating liposomal formulation of photo-sensitive agents is useful for PDT.},
	keywords = {BEARING MICE, benzoporphyrin, BENZOPORPHYRIN DERIVATIVES, BPD, CELLS, DERIVATIVE, drug delivery system, EFFICACY, INVIVO, LIPOPROTEINS, liposome, MURINE TUMOR-MODEL, PHOTODYNAMIC THERAPY, PHOTOSENSITIZER, time},
	isbn = {0918-6158},
	url = {<Go to ISI>://A1997XG54700016},
	author = {Oku, N. and Saito, N. and Namba, Y. and Tsukada, H. and Dolphin, D. and Okada, S.}
}
