@article {1598,
	title = {Metal complexes of maltol and close analogues in medicinal inorganic chemistry},
	journal = {Chemical Society Reviews},
	volume = {35},
	number = {6},
	year = {2006},
	note = {ISI Document Delivery No.: 047UHTimes Cited: 43Cited Reference Count: 181},
	pages = {545-556},
	type = {Review},
	abstract = {The family of hydroxypyrones and close congeners, the hydroxypyridinones, is a particularly versatile class of ligands. The most widely investigated for medicinal applications are the 3-hydroxy-4-pyrones and the 1,2- 3,2- and 3,4-hydroxypyridinones. Key features of these ligands are: a six-membered ring, with a ring N or O atom either ortho or para to a ketone group, and two ortho exocyclic oxygen atoms. Readily functionalizable, the hydroxypyrones and hydroxypyridinones allow one to achieve a range of di- and trivalent metallocomplex stabilities and can include tissue or molecular targeting features by design. Research over the past several decades has greatly expanded the array of ligands that are the subject of this critical review. Ligand applications as diverse as iron removal or supplementation, contrast agents in imaging applications, and mobilization of undesirable excess metal ions will be surveyed herein.},
	keywords = {DIELS-ALDER REACTION, ENHANCED PFE(3+) VALUES, ETHYL MALTOL, evaluation, IN-VIVO, ION SEQUESTERING AGENTS, IRON-DEFICIENCY ANEMIA, MONOLAYERS, MRI CONTRAST AGENTS, ORAL, RAT SMALL-INTESTINE, SELF-ASSEMBLED, VANADYL SULFATE},
	isbn = {0306-0012},
	url = {<Go to ISI>://000237903700006},
	author = {Thompson, K. H. and Barta, C. A. and Orvig, Chris}
}
@article {1373,
	title = {Recent approaches to the construction of 1-azaspiro[4.5]decanes and related 1-azaspirocycles},
	journal = {Tetrahedron},
	volume = {62},
	number = {15},
	year = {2006},
	note = {ISI Document Delivery No.: 027TBTimes Cited: 25Cited Reference Count: 147},
	month = {Apr},
	pages = {3467-3492},
	type = {Review},
	keywords = {3 degrees carbon center, AROMATIC PI-NUCLEOPHILE, azaspirocyclic ring systems, DIELS-ALDER REACTION, DIPOLAR CYCLOADDITION ROUTES, FORMAL TOTAL-SYNTHESIS, HYPERVALENT, IMMUNOSUPPRESSANT FR901483, IODINE OXIDATION, MARINE ALKALOID LEPADIFORMINE, N-ACYLNITRENIUM IONS, OXIDATIVE RADICAL CYCLIZATION, POTENT, RING-CLOSING METATHESIS, spirocycles},
	isbn = {0040-4020},
	url = {<Go to ISI>://000236437400001},
	author = {Dake, G. R.}
}
@article {1109,
	title = {An asymmetric formal synthesis of fasicularin},
	journal = {Chemistry-a European Journal},
	volume = {11},
	number = {2},
	year = {2005},
	note = {ISI Document Delivery No.: 887VLTimes Cited: 20Cited Reference Count: 138},
	month = {Jan},
	pages = {639-649},
	type = {Review},
	abstract = {An asymmetric formal synthesis of fasicularin (1) is described. This natural product, isolated from the extracts of the marine invertebrate Nephteis fasicularis, has shown modest cytotoxicity towards Vero cells. Fasicularin is among only two members of the cylindricine family of natural products, along with lepadiformine (2), to possess a trans A-B ring junction. Key steps of this approach to 1 involve a siloxy-epoxide semipinacol rearrangement of 5 to 6, a B-alkyl Suzuki-Miyaura coupling reaction by using enol trifluoromethanesulfonate 19 and a substrate-directed hydrogenation reaction of 24. This formal synthesis also highlights the difficulty in the incorporation of the thiocyanate functionality present in 1.},
	keywords = {ALKALOIDS, ALPHA-HYDROXY EPOXIDES, ASCIDIAN CLAVELINA-CYLINDRICA, BETA-SILOXY ALDEHYDES, CROSS-COUPLING, CROSS-COUPLING REACTION, DIELS-ALDER REACTION, ENANTIOSPECIFIC, EPOXY SILYL ETHERS, MARINE ALKALOID LEPADIFORMINE, REGIOSELECTIVE OLEFIN INSERTION, ring expansion, SEMI-PINACOL REARRANGEMENT, semipinacol rearrangement, spirocycle},
	isbn = {0947-6539},
	url = {<Go to ISI>://000226333500017},
	author = {Fenster, M. D. B. and Dake, G. R.}
}
@article {830,
	title = {Synthesis of functionalized 1-azaspirocyclic cyclopentanones using Bronsted acid or N-bromosuccinimide promoted ring expansions},
	journal = {Journal of Organic Chemistry},
	volume = {69},
	number = {17},
	year = {2004},
	note = {ISI Document Delivery No.: 845XHTimes Cited: 19Cited Reference Count: 128},
	month = {Aug},
	pages = {5668-5675},
	type = {Review},
	abstract = {Azaspirocyclic ring systems are present in a variety of alkaloids. Functionalized 1-azaspirocyclopentanones (6, 7, 11, 12) can be efficiently constructed through semipinacol ring expansion reactions of 2-(1-hydroxycyclobutyl)-p-toluenesulfonylenamides (4) promoted by either a Bronsted acid ((S)-(+)-10-camphorsulfonic acid or HCI) or N-bromosuccinimide, an electrophilic bromine source. Reactions promoted by N-bromosuccinimide tend to proceed in higher yields (80-95\%) and with greater diastereoselectivity (3:1-1:0) compared to those reactions promoted by a Bronsted acid. In addition, N-bromosuccinimide promoted reactions can produce a complementary stereochemical outcome compared to the reactions using Bronsted acid.},
	keywords = {1ST TOTAL-SYNTHESIS, ALPHA-HYDROXY IMINES, AMINO KETONE REARRANGEMENTS, CROSS-COUPLING, DIELS-ALDER REACTION, ENANTIOSELECTIVE, INITIATED PINACOL REARRANGEMENT, MARINE ALKALOIDS, PINNAIC ACID, REACTIONS, THERMAL REARRANGEMENT, TOTAL-SYNTHESIS},
	isbn = {0022-3263},
	url = {<Go to ISI>://000223278200020},
	author = {Dake, G. R. and Fenster, M. D. B. and Hurley, P. B. and Patrick, B. O.}
}
@article {612,
	title = {A formal construction of fasicularin},
	journal = {Organic Letters},
	volume = {5},
	number = {23},
	year = {2003},
	note = {ISI Document Delivery No.: 741QDTimes Cited: 23Cited Reference Count: 42},
	month = {Nov},
	pages = {4313-4316},
	type = {Article},
	abstract = {Our synthetic approach toward fasicularin is presented. Key steps in this construction are a siloxy-epoxide semipinacol rearrangement, a B-alkyl Suzuki reaction and an intramolecular S(N)2 reaction.},
	keywords = {(+/-)-LEPADIFORMINE, CROSS-COUPLING, CYLINDRICINE, DIELS-ALDER REACTION, DIPOLAR CYCLOADDITION, ENANTIOMER, KETONES, MARINE ALKALOID LEPADIFORMINE, NATURAL, reaction, REARRANGEMENT, STEREOSELECTIVE CONSTRUCTION},
	isbn = {1523-7060},
	url = {<Go to ISI>://000186468000019},
	author = {Fenster, M. D. B. and Dake, G. R.}
}
@article {678,
	title = {Template effect where 1-3 molecules drive formation of a trimer carceplex},
	journal = {Chemistry-a European Journal},
	volume = {9},
	number = {14},
	year = {2003},
	note = {ISI Document Delivery No.: 706XATimes Cited: 6Cited Reference Count: 46},
	month = {Jul},
	pages = {3253-3262},
	type = {Article},
	abstract = {The template effect in the formation of a trimer carceplex using 1-3 molecules as templates is explored. Thirteen different templates were studied and template ratios were measured for templates of like and unlike molecularity. Five transition-state models were studied for their binding abilities to see if these mirror the template ratios. The chemical shifts of the guests and the thermodynamic and kinetic values for templation suggest that binding is key, often tight, and that the guest determining step is formation of the last covalent bond. The molecular dynamics of guests as well as the conformational dynamics of both hosts and guests further addresses nature of the recognition between host and guest. Finally, we were surprised to discover that water can bind reversibly to the trimer carceplexes, which will have ramifications to any inner phase reactions conducted inside the cage.},
	keywords = {AMPLIFICATION, BARRIER, BINDING, CAPTURE, carceplex, CHEMISTRY, DIELS-ALDER REACTION, DYNAMICS, ELUCIDATION, ENCAPSULATION, HOST-GUEST COMPLEXATION, host-guest systems, molecular recognition, RESORCINARENE CAPSULE, REVERSIBLE, supramolecular, TEMPLATE SYNTHESIS},
	isbn = {0947-6539},
	url = {<Go to ISI>://000184479300009},
	author = {Makeiff, D. A. and Sherman, J. C.}
}
@article {4577,
	title = {Carceplexes and hemicarceplexes},
	journal = {Chemical Reviews},
	volume = {99},
	number = {4},
	year = {1999},
	note = {ISI Document Delivery No.: 189WZTimes Cited: 258Cited Reference Count: 229},
	month = {Apr},
	pages = {931-967},
	type = {Review},
	keywords = {CONSTRICTIVE BINDING, CRYSTAL-STRUCTURE, DIELS-ALDER REACTION, ENDOHEDRAL METALLOFULLERENES, ENERGY-TRANSFER, HOST-GUEST COMPLEXATION, HYDROGEN-BONDING PREFERENCES, REVERSIBLE MOLECULAR CAPSULES, SELF-ASSEMBLED MONOLAYERS, supramolecular chemistry, TRIPLET},
	isbn = {0009-2665},
	url = {<Go to ISI>://000079930300001},
	author = {Jasat, A. and Sherman, J. C.}
}
