@article {1436,
	title = {Glycosynthase-based synthesis of xylo-oligosaccharides using an engineered retaining xylanase from Cellulomonas fimi},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {4},
	number = {10},
	year = {2006},
	note = {ISI Document Delivery No.: 041NHTimes Cited: 20Cited Reference Count: 39},
	pages = {2025-2032},
	type = {Article},
	abstract = {Glycosynthases are synthetic enzymes derived from retaining glycosidases in which the catalytic nucleophile has been replaced. The mutation allows irreversible glycosylation of sugar acceptors using glycosyl fluoride donors to afford oligosaccharides without any enzymatic hydrolysis. Glycosynthase technology has proven fruitful for the facile synthesis of useful oligosaccharides, therefore the expansion of the glycosynthase repertoire is of the utmost importance. Herein, we describe for the first time a glycosynthase, derived from a retaining xylanase, that synthesizes a range of xylo-oligosaccharides. The catalytic domain of the retaining endo-1,4-beta-xylanase from Cellulomonas fimi (CFXcd) was successfully converted to the corresponding glycosynthase by mutation of the catalytic nucleophile to a glycine residue. The mutant enzyme (CFXcd-E235G) was found to catalyze the transfer of a xylobiosyl moiety from alpha-xylobiosyl fluoride to either p-nitrophenyl beta-xylobioside or benzylthio beta-xylobioside to afford oligosaccharides ranging in length from tetra- to dodecasaccharides. These products were purified by high performance liquid chromatography in greater than 60\% combined yield. H-1 and C-13 NMR spectroscopic analyses of the isolated p-nitrophenyl xylotetraoside and p-nitrophenyl xylohexaoside revealed that CFXcd-E235G catalyzes both the regio- and stereo-selective synthesis of xylo-oligosaccharides containing, exclusively, beta-(1 {\textendash}> 4) linkages.},
	keywords = {4-GLYCANASE, BETA-1, DIRECTED EVOLUTION, EFFICIENT SYNTHESIS, ENZYMATIC-SYNTHESIS, GLYCOSIDASES, MASS-SPECTROMETRY, SPECIFICITY, SUBSTRATE, TRANSGLYCOSYLATION, XYLOOLIGOSACCHARIDES},
	isbn = {1477-0520},
	url = {<Go to ISI>://000237462400022},
	author = {Kim, Y. W. and Fox, D. T. and Hekmat, O. and Kantner, T. and McIntosh, L. P. and Warren, R. A. J. and Withers, S. G.}
}
@article {1411,
	title = {Pyrrole synthesis catalyzed by AgOTf or cationic Au(I) complexes},
	journal = {Journal of Organic Chemistry},
	volume = {71},
	number = {12},
	year = {2006},
	note = {ISI Document Delivery No.: 049PTTimes Cited: 65Cited Reference Count: 71Harrison, Tyler J. Kozak, Jennifer A. Corbella-Pane, Montserrat Dake, Gregory R.},
	month = {Jun},
	pages = {4525-4529},
	type = {Article},
	abstract = {Either silver trifluoromethanesulfonate or a mixture of gold( I) chloride, silver trifluoromethanesulfonate, and triphenylphosphine catalyze the formation of pyrroles from substituted beta-alkynyl ketones and amines. The reactions proceed by using 5 mol \% of catalyst with yields of isolated pyrroles ranging from 13\% to 92\%. Sixteen examples are used to compare the effectiveness of each catalyst.},
	keywords = {2-PROPYNYL-1, 3-DICARBONYL COMPOUNDS, AMINATION/ANNULATION REACTIONS, C-H BONDS, CARBOXYLIC-ACIDS, DERIVATIVES, EFFICIENT SYNTHESIS, FURANS, ONE-POT, PYRROLES, REGIOSELECTIVE SYNTHESIS, SUBSTITUTED},
	isbn = {0022-3263},
	url = {<Go to ISI>://000238029300023},
	author = {Harrison, T. J. and Kozak, J. A. and Corbella-Pane, M. and Dake, G. R.}
}
@article {4499,
	title = {UDP-glucose analogues as inhibitors and mechanistic probes of UDP-glucose dehydrogenase},
	journal = {Journal of Organic Chemistry},
	volume = {64},
	number = {26},
	year = {1999},
	note = {ISI Document Delivery No.: 271NJTimes Cited: 15Cited Reference Count: 25},
	month = {Dec},
	pages = {9487-9492},
	type = {Article},
	abstract = {UDP-glucose dehydrogenase catalyzes the NAD(+)-dependent 2-fold oxidation of UDP-glucose to give UDP-glucuronic acid. The putative aldehyde intermediate is not released from the active site and is presumably tightly bound. We have prepared UDP-7-deoxy-alpha-D-gluco-hept-6-ulopyranose 5, that contains a methyl ketone at C-6 and cannot be further oxidized by the enzyme. Ketone 5 was found to be a competitive inhibitor of the dehydrogenase from Streptococcus pyogenes with a K-I value of 6.7 mu M. We have also prepared the secondary alcohols UDP-6S-6C-methylglucose, 4a, and UDP-6R-6C-methylglucose, 4b. Compound 4a, but not 4b, was found to be a slow substrate for the dehydrogenase and was converted into the ketone inhibitor 5. This is consistent with the notion that the pro-R hydride is transferred in the first oxidation step of the normal enzymatic reaction.},
	keywords = {EFFICIENT SYNTHESIS, FUCOSE, GROUP-A STREPTOCOCCI, nucleotides, POLYSACCHARIDE, VIRULENCE},
	isbn = {0022-3263},
	url = {<Go to ISI>://000084600100019},
	author = {Campbell, R. E. and Tanner, M. E.}
}
@article {4411,
	title = {Porphyrin-based photosensitizers for use in photodynamic therapy},
	journal = {Tetrahedron},
	volume = {54},
	number = {17},
	year = {1998},
	note = {ISI Document Delivery No.: ZF569Times Cited: 379Cited Reference Count: 376},
	month = {Apr},
	pages = {4151-4202},
	type = {Review},
	keywords = {(+/-)-BONELLIN DIMETHYL ESTER, ALGA, BLOOD PIGMENT HEME, CHLORIN, CHLOROPHYLL DERIVATIVES, E6 NPE6, EFFICIENT SYNTHESIS, HIGH-YIELD SYNTHESIS, NICKEL BETA-OXOPORPHYRINS, PHOTOFRIN-II, SUBSTITUTED PORPHYRINS, TOLYPOTHRIX-NODOSA},
	isbn = {0040-4020},
	url = {<Go to ISI>://000072910600001},
	author = {Sternberg, E. D. and Dolphin, D. and Bruckner, C.}
}
@article {3262,
	title = {2,3-VIC-DIHYDROXY-MESO-TETRAPHENYLCHLORINS FROM THE OSMIUM-TETROXIDE OXIDATION OF MESO-TETRAPHENYLPORPHYRIN},
	journal = {Tetrahedron Letters},
	volume = {36},
	number = {19},
	year = {1995},
	note = {ISI Document Delivery No.: QY111Times Cited: 34Cited Reference Count: 25},
	month = {May},
	pages = {3295-3298},
	type = {Article},
	abstract = {meso-Tetraphenylporphyrins and meso-tetraphenylmetalloporphyrins were converted into stable 2,3-vic-dihydroxy-meso-tetraphenylchlorins and 2,3-vic-dihydroxy-meso-tetraphenylmetallochlorins by oxidation with stoichiometric amounts of OsO4 and subsequent reduction of the isolable osmate esters. The stable dihydroxychlorins were dehydrated under acid catalysis to yield 2-hydroxy-meso-tetraphenylporphyrins.},
	keywords = {BACTERIOCHLORINS, chlorins, EFFICIENT SYNTHESIS, PHOTODYNAMIC THERAPY, porphyrins, TUMOR PHOTOSENSITIZERS},
	isbn = {0040-4039},
	url = {<Go to ISI>://A1995QY11100002},
	author = {Bruckner, C. and Dolphin, D.}
}
