@article {2107,
	title = {Synthetic studies toward halichlorine: Complex azaspirocycle formation with use of an NBS-promoted semipinacol reaction},
	journal = {Journal of Organic Chemistry},
	volume = {73},
	number = {11},
	year = {2008},
	note = {ISI Document Delivery No.: 307MRTimes Cited: 13Cited Reference Count: 90Hurley, Paul B. Dake, Gregory R.},
	month = {Jun},
	pages = {4131-4138},
	type = {Article},
	abstract = {The investigations of a synthetic route incorporating a NIBS-promoted semipinacol rearrangement to the 6-azaspiro[4.5]decane fragment within halichlorine (1) are presented. A convergent approach was pursued, utilizing two chiral, enantiomerically enriched building blocks, 2-trimethylstannyl piperidene 10 and substituted cyclobutanone 19. Noteworthy synthetic operations in this study include the following: (a) a highly diastereoselective NBS-promoted semipinacol reaction that established four stereogenic centers in ketone 25 and (b) the use of a N-p-toluenesulfonyl-2-iodo-2-piperidene as a precursor to a basic organometallic reagent, which was critical to the success of the coupling of fragments 10 and 19.},
	keywords = {(+/-)-PINNAIC ACID, ASYMMETRIC-SYNTHESIS, BAEYER-VILLIGER OXIDATION, CARBOXYLIC-ACIDS, CRIEGEE REARRANGEMENT, ETHYLMAGNESIUM BROMIDE, ORGANIC-SYNTHESIS, PINNAIC ACID, RING-CLOSING METATHESIS, SPIROCYCLIC CORE},
	isbn = {0022-3263},
	url = {<Go to ISI>://000256323500018},
	author = {Hurley, P. B. and Dake, G. R.}
}
@article {1373,
	title = {Recent approaches to the construction of 1-azaspiro[4.5]decanes and related 1-azaspirocycles},
	journal = {Tetrahedron},
	volume = {62},
	number = {15},
	year = {2006},
	note = {ISI Document Delivery No.: 027TBTimes Cited: 25Cited Reference Count: 147},
	month = {Apr},
	pages = {3467-3492},
	type = {Review},
	keywords = {3 degrees carbon center, AROMATIC PI-NUCLEOPHILE, azaspirocyclic ring systems, DIELS-ALDER REACTION, DIPOLAR CYCLOADDITION ROUTES, FORMAL TOTAL-SYNTHESIS, HYPERVALENT, IMMUNOSUPPRESSANT FR901483, IODINE OXIDATION, MARINE ALKALOID LEPADIFORMINE, N-ACYLNITRENIUM IONS, OXIDATIVE RADICAL CYCLIZATION, POTENT, RING-CLOSING METATHESIS, spirocycles},
	isbn = {0040-4020},
	url = {<Go to ISI>://000236437400001},
	author = {Dake, G. R.}
}
