@article {2360,
	title = {Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia},
	journal = {Schizophrenia Research},
	volume = {109},
	number = {1-3},
	year = {2009},
	note = {ISI Document Delivery No.: 437VZTimes Cited: 3Cited Reference Count: 52Beasley, Clare L. Dwork, Andrew J. Rosoklija, Gorazd Mann, J. John Mancevski, Branislav Jakovski, Zlatko Davceva, Natasa Tait, Andrew R. Straus, Suzana K. Honer, William G.},
	month = {Apr},
	pages = {159-166},
	type = {Article},
	abstract = {{The anterior limb of the internal capsule (ALIC) is the major white matter tract providing reciprocal connections between the frontal cortex, striatum and thalamus. Mounting evidence suggests that this tract may be affected in schizophrenia, with brain imaging studies reporting reductions in white matter volume and density, changes in fractional anisotropy and reduced asymmetry. However, the molecular correlates of these deficits are currently unknown. The aim of this study was to identify alterations in protein and metabolite levels in the ALIC in schizophrenia. Samples were obtained post-mortem from individuals with schizophrenia (n = 15) and non-psychiatric controls (n = 13). Immunoreactivity for the myelin-associated protein myelin basic protein (MBP), and the axonal-associated proteins phosphorylated neurofilament and SNAP-25 was measured by enzyme-linked immunoadsorbent assay (ELISA). Metabolite concentrations were quantified by proton nuclear magnetic resonance (H-1 NMR) spectroscopy. Levels of myelin- or axonal-associated proteins did not differ between groups. Overall differences in metabolite concentrations were observed between the two groups (MANOVA F=2.685},
	keywords = {ANTERIOR CINGULATE CORTEX, Axon, BASAL GANGLIA, composition, CORPUS-CALLOSUM, EXPRESSION, fiber, HUMAN INTERNAL CAPSULE, Internal capsule, LACTATE, MENTAL-ILLNESS, METABOLITE, myelin, POLARIZED-LIGHT, POSTMORTEM BRAINS, PREFRONTAL CORTEX, SEVERE},
	isbn = {0920-9964},
	url = {<Go to ISI>://000265516300023},
	author = {Beasley, C. L. and Dwork, A. J. and Rosoklija, G. and Mann, J. J. and Mancevski, B. and Jakovski, Z. and Davceva, N. and Tait, A. R. and Straus, S. K. and Honer, W. G.}
}
@article {1112,
	title = {Chromatographic separation and identification of products from the reaction of dimethylarsinic acid with hydrogen sulfide},
	journal = {Chemical Research in Toxicology},
	volume = {18},
	number = {12},
	year = {2005},
	note = {ISI Document Delivery No.: 004XYTimes Cited: 24Cited Reference Count: 44},
	month = {Dec},
	pages = {1821-1829},
	type = {Article},
	abstract = {The reaction of dimethylarsinic acid (DMA(V)) with hydrogen sulfide (H2S) is of biological significance and may be implicated in the overall toxicity and carcinogenicity of arsenic. The course of the reaction in aqueous phase was monitored, and an initial product, dimethylthioarsinic acid, was observed by using LC-ICP-MS and LC-ESI-MS. Dimethylarsinous acid was observed as a minor product. A second slower-forming product was identified, and the electrospray mass chromatograms for this species produced ions at m/z 275, 171, and 137 in positive mode. To aid in the identification of this slower-forming product, crystalline standards of sodium dimethyldithioarsinate and dimethylarsino dimethyldithioarsinate were prepared and re-characterized by using improved spectroscopic and structural analysis techniques. An aqueous solution of sodium dimethyldithioarsinate produced a single major chromatographic peak that matched the retention time (7.6 min) of the slower-forming product and contained similar molecular ions at m/z 275, 171, and 137 via LC-ESI-MS. The dimethylarsino dimethyldithioarsinate standard produced four aqueous phase species one of which coeluted with the slower forming product. This coeluting peak also produced the identical ESI-MS ions as the slower-forming product of DMA(V) + H2S. ESI-MS/MS experiments conducted on sodium dimethyldithioarsinate in deuterated water produced molecular ions at m/z 276, 173, and 137. Subsequent collisionally activated dissociation (CAD) experiments on m/z 276 did not produce a product ion at m/z 173. These data indicate that two different species are present in solution, while NMR data indicate that only dimethyldithioarsinic acid exists in aqueous solutions. This discrepancy was investigated by conducting NMR studies on the acidic solution of sodium dimethyldithioarsinate after taking this solution to dryness. The resolubilized solution produced a proton NMR signal characteristic of dimethylarsino dimethyldithioarsinate. Therefore, it was concluded that the ESI-MS ion at m/z 275 associated with the slowly forming second reaction product and the sodium dimethyldithioarsinate compound is a product of the ESI desolvation process.},
	keywords = {CRYSTAL-STRUCTURE, DIMETHYLDITHIOARSINATE, GLUTATHIONE, METABOLITE, ORGANIC ARSENIC COMPOUNDS, RATS, REARRANGEMENT, TOXICITY, TRIMETHYLARSINE OXIDE, urine},
	isbn = {0893-228X},
	url = {<Go to ISI>://000234787200005},
	author = {Fricke, M. W. and Zeller, M. and Sun, H. and Lai, V. W. M. and Cullen, W. R. and Shoemaker, J. A. and Witkowski, M. R. and Creed, J. T.}
}
@article {1307,
	title = {Synthesis of pelorol and analogues: Activators of the inositol 5-phosphatase SHIP},
	journal = {Organic Letters},
	volume = {7},
	number = {6},
	year = {2005},
	note = {ISI Document Delivery No.: 906DPTimes Cited: 19Cited Reference Count: 18},
	month = {Mar},
	pages = {1073-1076},
	type = {Article},
	abstract = {A screening program designed to find new antiinflammatory agents has identified the sponge meroterpenoid pelorol (1) as an in vitro activator of the inositol-5-phosphatase SHIP. Pelorol (1) and several functional group analogues have been synthesized from sclareolide (4).},
	keywords = {CELLS, METABOLITE, MICE, SPONGE DACTYLOSPONGIA-ELEGANS},
	isbn = {1523-7060},
	url = {<Go to ISI>://000227621000030},
	author = {Yang, L. and Williams, D. E. and Mui, A. and Ong, C. and Krystal, G. and Van Soest, R. and Andersen, R. J.}
}
@article {3744,
	title = {Microbial degradation of pyrene and characterization of a metabolite},
	journal = {Science of the Total Environment},
	volume = {177},
	year = {1996},
	note = {ISI Document Delivery No.: TP870Times Cited: 10Cited Reference Count: 37},
	month = {Jan},
	pages = {17-29},
	type = {Article},
	abstract = {We report the degradation of pyrene by microorganisms present in sea water and sediment samples that were obtained from Kitimat Arm, BC, Canada, an environment that is highly contaminated by polycyclic aromatic hydrocarbons because of nearby aluminum smelting activity. The utilization of pyrene as sole carbon source by the microorganisms is demonstrated by monitoring the disappearance of pyrene and the production of its metabolite in the cultures. Pyrene (10 mu g) is degraded to an undetectable level after 120 h of incubation with 0.5 mi of the enriched culture and 10 ml of mineral salt medium. The extent of mineralization is also assessed by determining the radioactivity of the (CO2)-C-14 produced from the cultures containing C-14-labeled pyrene: up to 65\% of the pyrene is mineralized after 12 days of incubation. A metabolite that accumulates in the pyrene degradation cultures can be isolated. This metabolite is identified as cis-dihydrodiol pyrene, an initial ring oxidation product, on the basis of its chromatographic behavior, absorption spectrum, fluorescence excitation and emission spectra, and mass spectra.},
	keywords = {BACTERIAL, BIODEGRADATION, bioremediation, cis-dihydrodiol pyrene, CONTAMINATED SOIL, HYDROCARBONS, METABOLITE, microbial degradation, MINERALIZATION, MYCOBACTERIUM SP, NAPHTHALENE, OXIDATION, PHENANTHRENE, polycyclic aromatic, POLYCYCLIC AROMATIC-HYDROCARBONS, PYRENE, SEDIMENT},
	isbn = {0048-9697},
	url = {<Go to ISI>://A1996TP87000003},
	author = {Li, X. F. and Cullen, W. R. and Reimer, K. J. and Le, X. C.}
}
@article {6977,
	title = {THE STRUCTURE AND PARTIAL SYNTHESIS OF IMBRICATINE, A BENZYLTETRAHYDROISOQUINOLINE ALKALOID FROM THE STARFISH DERMASTERIAS-IMBRICATA},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {69},
	number = {1},
	year = {1991},
	note = {ISI Document Delivery No.: EW991Times Cited: 18Cited Reference Count: 20},
	month = {Jan},
	pages = {20-27},
	type = {Article},
	abstract = {The structure of imbricatine (1), a cytotoxic metabolite of the starfish Dermasterias imbricata, has been determined by spectroscopic analysis and chemical degradation. Synthesis of model compounds 7 and 18 provided evidence for the absolute configuration and constitution of the benzyltetrahydroisoquinoline substructure of imbricatine.},
	keywords = {ALKALOID, ASTEROID, IMBRICATINE, METABOLITE},
	isbn = {0008-4042},
	url = {<Go to ISI>://A1991EW99100004},
	author = {Burgoyne, D. L. and Miao, S. and Pathirana, C. and Andersen, R. J. and Ayer, W. A. and Singer, P. P. and Kokke, Wcmc and Ross, D. M.}
}
