@article {2684,
	title = {Development of an Oxazole Conjunctive Reagent and Application to the Total Synthesis of Siphonazoles},
	journal = {Journal of Organic Chemistry},
	volume = {74},
	number = {23},
	year = {2009},
	note = {ISI Document Delivery No.: 523ONTimes Cited: 6Cited Reference Count: 120Zhang, Jianmin Polishchuk, Elena A. Chen, Jie Ciufolini, Marco A.},
	month = {Dec},
	pages = {9140-9151},
	type = {Review},
	abstract = {The preparation of 4-carbethoxy-5-methyl-2-(phenylsulfonyl)methyloxizole and Its use in the elaboration of more complex oxazoles are described. A total synthesis of the unique natural products siphonazoles A and B, illustrates an application of this building block. A discussion of the biological activity of the siphonazoles is also presented.},
	keywords = {1ST TOTAL-SYNTHESIS, ALLENYL ESTERS, CONJUGATED, CYANOBACTERIUM NOSTOC-MUSCORUM, CYTOTOXIC, DIAZONAMIDE-A, DOUBLE ELIMINATION PROTOCOL, GLYOXYLIC-ACID DERIVATIVES, INTRAMOLECULAR HYDROAMINATION, marine sponge, METABOLITES, NATURAL-PRODUCT HENNOXAZOLE},
	isbn = {0022-3263},
	url = {<Go to ISI>://000272083700026},
	author = {Zhang, J. M. and Polishchuk, E. A. and Chen, J. and Ciufolini,Marco A.}
}
@article {1632,
	title = {A synthetic approach toward nitiol: Construction of two 1,22-dihydroxynitianes},
	journal = {Journal of Organic Chemistry},
	volume = {71},
	number = {11},
	year = {2006},
	note = {ISI Document Delivery No.: 044EATimes Cited: 8Cited Reference Count: 131Wilson, Michael S. Woo, Jacqueline C. S. Dake, Gregory R.},
	month = {May},
	pages = {4237-4245},
	type = {Review},
	abstract = {Synthetic work toward the total synthesis of nitiol has culminated in the construction of two epimeric hydroxylated derivatives, the 1,22-dihydroxynitianes. Key stereodefining steps in the construction of the A-ring fragment (13) were the use of a siloxy-epoxide rearrangement reaction, a Pauson-Khand reaction, a Norrish 1 photochemical cleavage reaction, and a highly regio- and stereoselective hydrostannylation reaction of an ynoate. The stereochemistry of the synthetically challenging C-ring fragment (20) was established using an Ireland-Claisen reaction and a Grubbs ring-closing metathesis process as key steps. The 12-membered B-ring of the nitiane skeleton was constructed using a copper-promoted Stille cross-coupling and a Kishi-Hiyama-Nozaki carbonyl addition reaction. Unfortunately, the carbonyl addition reaction produced hydroxyl functionality that could not be selectively removed. Consequently, a synthesis of epimeric 1,22-dihydroxynitianes, which are compounds that are structural hybrids of two natural products, nitiol and variculanol, was completed.},
	keywords = {1ST TOTAL-SYNTHESIS, ACTIVE, ALKYL BROMIDES, ARYL GRIGNARD-REAGENTS, BETA-SILOXY ALDEHYDES, CARBON BOND FORMATION, IRELAND-CLAISEN REARRANGEMENT, PAUSON-KHAND REACTION, PLAGIOSPIROLIDE-A, TRANSITION-METAL CATALYSIS, ZIRCONIUM-CATALYZED CARBOALUMINATION},
	isbn = {0022-3263},
	url = {<Go to ISI>://000237654000027},
	author = {Wilson, M. S. and Woo, J. C. S. and Dake, G. R.}
}
@article {829,
	title = {Investigations of alpha-siloxy-epoxide ring expansions forming 1-azaspirocyclic ketones},
	journal = {Journal of Organic Chemistry},
	volume = {69},
	number = {17},
	year = {2004},
	note = {ISI Document Delivery No.: 845XHTimes Cited: 13Cited Reference Count: 97},
	month = {Aug},
	pages = {5676-5683},
	type = {Article},
	abstract = {The construction of 1-azaspirocyclic cycloalkanones using a siloxy-epoxide semipinacol ring expansion process was examined. Functionalized 1-azaspiro[5.5]undecan-7-ones (1-azaspirocyclic cyclohexanones) proceeded in high chemical yields with complete diastereoselectivity using titanium tetrachloride as the Lewis acid promoter. The formation of functionalized 6-azaspiro[5.4]-decan-1-ones (1-azaspirocyclic cyclopentanones) proceeded in high chemical yield with little diastereoselectivity. Modification of reaction parameters such as the Lewis acid promoter or the nature of the silyl ether allowed for the preferential formation of either ("anti" or "syn" 1,2 alkyl shift) diastereomeric product. An explanation for the different reactivity profiles between the cyclobutanol silyl ethers and cyclopentanol silyl ethers is provided.},
	keywords = {1ST TOTAL-SYNTHESIS, ALDOL ALDOL PROCESS, ASYMMETRIC-SYNTHESIS, BAEYER-VILLIGER OXIDATION, LEWIS-ACIDS, ORGANIC-SYNTHESIS, PRACTICAL, QUATERNARY CARBON CENTERS, REARRANGEMENT, SEMI-PINACOL, SILYL ETHER REARRANGEMENTS, STEREOSELECTIVE CONSTRUCTION},
	isbn = {0022-3263},
	url = {<Go to ISI>://000223278200021},
	author = {Dake, G. R. and Fenster, M. D. B. and Fleury, M. and Patrick, B. O.}
}
@article {830,
	title = {Synthesis of functionalized 1-azaspirocyclic cyclopentanones using Bronsted acid or N-bromosuccinimide promoted ring expansions},
	journal = {Journal of Organic Chemistry},
	volume = {69},
	number = {17},
	year = {2004},
	note = {ISI Document Delivery No.: 845XHTimes Cited: 19Cited Reference Count: 128},
	month = {Aug},
	pages = {5668-5675},
	type = {Review},
	abstract = {Azaspirocyclic ring systems are present in a variety of alkaloids. Functionalized 1-azaspirocyclopentanones (6, 7, 11, 12) can be efficiently constructed through semipinacol ring expansion reactions of 2-(1-hydroxycyclobutyl)-p-toluenesulfonylenamides (4) promoted by either a Bronsted acid ((S)-(+)-10-camphorsulfonic acid or HCI) or N-bromosuccinimide, an electrophilic bromine source. Reactions promoted by N-bromosuccinimide tend to proceed in higher yields (80-95\%) and with greater diastereoselectivity (3:1-1:0) compared to those reactions promoted by a Bronsted acid. In addition, N-bromosuccinimide promoted reactions can produce a complementary stereochemical outcome compared to the reactions using Bronsted acid.},
	keywords = {1ST TOTAL-SYNTHESIS, ALPHA-HYDROXY IMINES, AMINO KETONE REARRANGEMENTS, CROSS-COUPLING, DIELS-ALDER REACTION, ENANTIOSELECTIVE, INITIATED PINACOL REARRANGEMENT, MARINE ALKALOIDS, PINNAIC ACID, REACTIONS, THERMAL REARRANGEMENT, TOTAL-SYNTHESIS},
	isbn = {0022-3263},
	url = {<Go to ISI>://000223278200020},
	author = {Dake, G. R. and Fenster, M. D. B. and Hurley, P. B. and Patrick, B. O.}
}
