@article {1600,
	title = {Metal complexes in medicinal chemistry: new vistas and challenges in drug design},
	journal = {Dalton Transactions},
	number = {6},
	year = {2006},
	note = {ISI Document Delivery No.: 014YVTimes Cited: 60Cited Reference Count: 44},
	month = {Feb},
	pages = {761-764},
	type = {Article},
	abstract = {An overview is presented of selected metal-bases! pharmaceuticals, either diagnostic or therapeutic, with emphasis on specific attributes and in vivo interactions of these compounds relevant to their use in medicinal applications. Both the advantages and the challenges of this approach are outlined, with possibilities for future developments accentuated.},
	keywords = {AGENTS, BINDING CONSTANTS, BIS(MALTOLATO)OXOVANADIUM(IV), GLUCOSE, HUMAN-SERUM TRANSFERRIN, MODULATION, therapy, TRANSPORT},
	isbn = {1477-9226},
	url = {<Go to ISI>://000235520000001},
	author = {Thompson, K. H. and Orvig, Chris}
}
@article {4957,
	title = {Design of vanadium compounds as insulin enhancing agents},
	journal = {Journal of the Chemical Society-Dalton Transactions},
	number = {17},
	year = {2000},
	note = {ISI Document Delivery No.: 348MDTimes Cited: 77Cited Reference Count: 123},
	pages = {2885-2892},
	type = {Review},
	abstract = {Vanadium compounds, in vitro, stimulate glucose uptake and inhibit lipid breakdown, in a manner remarkably reminiscent of insulin{\textquoteright}s effects. In vivo, vanadium enhances insulin{\textquoteright}s plasma glucose and lipid-lowering properties, leading to normalization of diabetic symptoms in the presence of only minimal endogenous insulin. The coordination chemistry of vanadium has great versatility for adjustment of pharmacological characteristics. Vanadium compounds are generally also very redox active, which is both advantageous and detrimental for optimizing biochemical function. In this perspective, we review and comment on how these properties have been revealed, what questions have arisen along the way, and where future investigations may be headed. While this is not a comprehensive overview of all available compounds touted as {\textquoteright}insulin enhancing agents{\textquoteright}, it will focus on those which are distinctive in some way, or which are representative of the larger library of vanadium compounds, including all currently known relevant oxidation states of vanadium.},
	keywords = {AGENT, BIOLOGICAL-SYSTEMS, DEPENDENT DIABETES-MELLITUS, ECHO ENVELOPE, GLUCOSE-METABOLISM, IN-VIVO, MIMETIC, MODULATION, PEROXOVANADIUM COMPOUNDS, SKELETAL-MUSCLE, STREPTOZOTOCIN-TREATED RATS, TYROSINE PHOSPHORYLATION},
	isbn = {1470-479X},
	url = {<Go to ISI>://000088987800001},
	author = {Thompson, K. H. and Orvig, Chris}
}
