@article {1603,
	title = {The anti-invasive compound motuporamine C is a robust stimulator of neuronal growth cone collapse},
	journal = {Neuroscience},
	volume = {139},
	number = {4},
	year = {2006},
	note = {ISI Document Delivery No.: 044SBTimes Cited: 7Cited Reference Count: 41},
	pages = {1263-1274},
	type = {Article},
	abstract = {Neuronal outgrowth is a fundamental process for normal development of the nervous system. Despite recent advances, the molecular mechanisms governing neuronal motility are still poorly understood. To provide insight into the intracellular signaling mechanisms required for neuronal outgrowth, we have characterized the effects of a compound previously identified for its anti-motility effects on transformed cells. We show that this compound, motuporamine C, acts as a robust inhibitor of chick neurite outgrowth in a dose-dependent fashion. Furthermore, in the presence of motuporamine C, growth cone collapse is observed, followed by neurite retraction. After removal, growth cones re-extend lamellipodial and filopodial processes and re-establish motility. Neurons exposed to motuporamine C exhibit a significant upregulation of active Rho-GTP. Additionally, effector-blocking experiments using Rho and Rho-associated kinase inhibitors indicate that the Rho pathway plays a critical role in motuporamine C-mediated growth cone collapse. Thus, we have characterized a novel anti-motility compound that has a robust inhibitory effect on neuronal outgrowth and involves signaling through the Rho-Rho kinase collapse pathway. Due to these robust effects, motuporamine C may serve as a valuable tool in further examining the intracellular mechanisms associated with growth cone motility. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.},
	keywords = {ACTIN STRESS FIBERS, ADP-RIBOSYLATION, AXONAL GROWTH, BINDING PROTEIN-RHO, collapse, development, FOCAL ADHESIONS, growth cone, IN-VIVO, KINASE-ACTIVITY, LYSOPHOSPHATIDIC ACID, motuporamine, NEURITE RETRACTION, outgrowth, RECEPTORS, Rho GTPase},
	isbn = {0306-4522},
	url = {<Go to ISI>://000237691600009},
	author = {To, K. C. W. and Loh, K. T. and Roskelley, C. D. and Andersen, R. J. and O{\textquoteright}Connor, T. P.}
}
@article {4316,
	title = {The coupling of electron thermalization and electron attachment in CCl4/Ar and CCl4/Ne mixtures},
	journal = {Journal of Chemical Physics},
	volume = {108},
	number = {4},
	year = {1998},
	note = {ISI Document Delivery No.: YR488Times Cited: 11Cited Reference Count: 61},
	month = {Jan},
	pages = {1587-1600},
	type = {Article},
	abstract = {The relaxation of a nonequilibrium distribution of electrons in a mixture of CCl4 with either Ar or Ne is studied. In this paper, electron-CCl4 and electron-inert gas elastic collisions, vibrationally inelastic collisions between electrons and CCl4, as well as the electron attachment reaction with CCl4, are included in the analysis. The time dependent electron energy distribution function is determined from the Boltzmann equation and the energy relaxation times are determined. The coupling of the thermalization process and the attachment process are discussed in detail. The results from the calculations are analyzed analogous to experimental studies, and the methodology of the experimental reduction of the data is studied. (C) 1998 American Institute of Physics.},
	keywords = {ARGON, CONDUCTIVITY, CROSS-SECTIONS, DEGRADATION, development, FIELD DEPENDENCE, MONTE-CARLO SIMULATION, RARE-GAS MODERATORS, SF6, SWARM, TRANSPORT},
	isbn = {0021-9606},
	url = {<Go to ISI>://000071500300035},
	author = {Kowari, K. and Leung, K. and Shizgal, B. D.}
}
