@article {574,
	title = {Complementary on-line preconcentration strategies for steroids by capillary electrophoresis},
	journal = {Journal of Chromatography A},
	volume = {1013},
	number = {1-2},
	year = {2003},
	note = {ISI Document Delivery No.: 727KJTimes Cited: 47Cited Reference Count: 4416th International Symposium on Microscale Separation and AnalysisJAN 17-22, 2003SAN DIEGO, CALIFORNIA},
	month = {Sep},
	pages = {65-76},
	type = {Proceedings Paper},
	abstract = {Complementary on-line preconcentration strategies are needed when analyzing different classes of solutes in real samples by capillary electrophoresis (CE) with UV detection. The performance of three different on-line preconcentration (focusing) techniques under alkaline conditions was examined in terms of their selectivity and sensitivity enhancement for a group of steroids, including classes of androgens, corticosteroids and estrogens. Electrokinetic focusing of large sample injection plugs (up to 28\% of effective capillary length or 22.1 cm) directly on-capillary can be tuned for specific classes of steroids based on changes in their mobility (velocity) using a multi-section electrolyte system in CE. A dynamic pH junction was applied for the selective resolution and focusing of weakly acidic estrogens using borate, pH 11.0 and pH 8.0 in the background electrolyte and the sample, respectively. Sweeping, using an anionic bile acid surfactant and neutral gamma-cyclodextrin (gamma-CD) under alkaline conditions (pH 8), resulted in focusing and separation of the moderately hydrophobic (non-ionic) classes of steroids, such as androgen and corticosteroids. Optimal focusing and resolution of all test steroids under a single buffer condition was realized by a dynamic pH junction-sweeping format using borate, pH 11.0 and bile acid surfactant with gamma-CD in the BGE, whereas the sample is devoid of surfactant at pH 8.0. The design of selective on-line focusing strategies in CE is highlighted by the analysis of microgram amounts of ethynyl estradiol derived from a female contraceptive pill extract using the dynamic pH junction method, which resulted in over a 100-fold enhancement in concentration sensitivity. (C) 2003 Elsevier B.V. All rights reserved.},
	keywords = {dynamic pH, dynamic pH junction, EPINEPHRINE, FLUORESCENCE DETECTION, INDUCED, INJECTION, MICELLAR ELECTROKINETIC CHROMATOGRAPHY, NEUTRAL ANALYTES, sample preparation, SAMPLE SELF-STACKING, SEPARATION, steroids, sweeping, TAURODEOXYCHOLATE, ZONE-ELECTROPHORESIS},
	isbn = {0021-9673},
	url = {<Go to ISI>://000185656900009},
	author = {Britz-McKibbin, P. and Ichihashi, T. and Tsubota, K. and Chen, D. D. Y. and Terabe, S.}
}
@article {4490,
	title = {Analysis of epinephrine from fifteen different dental anesthetic formulations by capillary electrophoresis},
	journal = {Journal of Chromatography A},
	volume = {853},
	number = {1-2},
	year = {1999},
	note = {ISI Document Delivery No.: 229VXTimes Cited: 31Cited Reference Count: 512th International Symposium on High Performance Capillary Electrophoresis and Related Microscale TechniquesJAN 23-28, 1999PALM SPRINGS, CALIFORNIA},
	month = {Aug},
	pages = {535-540},
	type = {Proceedings Paper},
	abstract = {A robust method for the quantification of epinephrine from 15 different commercial dental anesthetic formulations is developed using CE. This work presents an extension to a method reported earlier. The solvability of several anesthetic compounds was improved through appropriate dilutions and the addition of sodium dodecyl sulfate to the separation background electrolyte. By controlling the mobility of the analyte at different pH values, a dilute solution of epinephrine is focused into a sharp zone with the injection of about 150 nl of anesthetic solution into the capillary. This on-column concentration technique extended the concentration detection limit of epinephrine to about 5.0 x 10(-7) M using a commercially available UV detector. A correlation plot between the measured and listed epinephrine concentration for the 15 dental anesthetic solutions demonstrated excellent accuracy of this method. (C) 1999 Elsevier Science B.V. All rights reserved.},
	keywords = {EPINEPHRINE, pharmaceutical analysis},
	isbn = {0021-9673},
	url = {<Go to ISI>://000082217400059},
	author = {Britz-McKibbin, P. and Wong, J. and Chen, D. D. Y.}
}
@article {4213,
	title = {Quantitative assay fdr epinephrine in dental anesthetic solutions by capillary electrophoresis},
	journal = {Analyst},
	volume = {123},
	number = {7},
	year = {1998},
	note = {ISI Document Delivery No.: 102JCTimes Cited: 40Cited Reference Count: 19},
	month = {Jul},
	pages = {1461-1463},
	type = {Article},
	abstract = {A simple and robust method for the separation and quantification of epinephrine in dental anesthetic solutions was developed. The method allows the direct injection of high salt solutions without Sample pre-treatment. Large sample plugs (5.7\% of the total capillary length) are used for epinephrine determination by selective analyte focusing in capillary electrophoresis, The concentration detection limit for epinephrine is about 5.0 x 10(-7) M (90 ng ml(-1)) with a commercial UV detector. The separation protocol was validated in terms of its precision, linearity, accuracy and specificity.},
	keywords = {analyte focusing, capillary electrophoresis, CHROMATOGRAPHY, dental anesthetic solutions, EPINEPHRINE, INJECTION, LIDOCAINE, SAMPLES, STACKING, TETRACAINE, ZONE ELECTROPHORESIS},
	isbn = {0003-2654},
	url = {<Go to ISI>://000074920200007},
	author = {Britz-McKibbin, P. and Kranack, A. R. and Paprica, A. and Chen, D. D. Y.}
}
