@article {1480, title = {Electrospray ionization source geometry for mass spectrometry: past, present, and future}, journal = {Trac-Trends in Analytical Chemistry}, volume = {25}, number = {3}, year = {2006}, note = {ISI Document Delivery No.: 026CJTimes Cited: 34Cited Reference Count: 130}, month = {Mar}, pages = {243-256}, type = {Review}, abstract = {The geometry of an electrospray ion source plays important roles in the processes of analyte desolvation, ionization, transportation, and detection in a mass spectrometer. We provide a brief account of the scientific principles involved in developing an electrospray ion source, and in the various geometries used to improve the sensitivity of mass spectrometry. We also present some popular configurations currently available and outline future trends in this research area. (C) 2005 Elsevier Ltd. All rights reserved.}, keywords = {ANALYSIS SYSTEMS, atmospheric pressure ionization, ATMOSPHERIC-PRESSURE, CAPILLARY-ZONE-ELECTROPHORESIS, CHARGED DROPLETS, commercial ion source design, electrospray ionization, ion source, ion source geometry, mass, MICRO-ELECTROSPRAY, MICROFLUIDIC DEVICES, NANOSCALE LIQUID-CHROMATOGRAPHY, PRESSURE ION LENS, PROTEIN IDENTIFICATION, SOLUTION FLOW-RATES, SPECTROMETRY}, isbn = {0165-9936}, url = {://000236314000013}, author = {Manisali, I. and Chen, D. D. Y. and Schneider, B. B.} } @article {942, title = {Continuous electrophoretic purification of individual analytes from multicomponent mixtures}, journal = {Analytical Chemistry}, volume = {76}, number = {8}, year = {2004}, note = {ISI Document Delivery No.: 816FWTimes Cited: 10Cited Reference Count: 36}, month = {Apr}, pages = {2298-2305}, type = {Article}, abstract = {Individual analytes can be isolated from multicomponent mixtures and collected in the outlet vial by carrying out electrophoretic purification through a capillary column. Desired analytes are allowed to migrate continuously through the column under the electric field while undesired analytes are confined to the inlet vial by application of a hydrodynamic counter pressure. Using pressure ramping and buffer replenishment techniques, 18\% of the total amount present in a bulk sample can be purified when the resolution to the adjacent peak is similar to3. With a higher resolution, the yield could be further improved. Additionally, by periodically introducing fresh buffer into the sample, changes in pH and conductivity can be mediated, allowing higher purity (99.5\%) to be preserved in the collected fractions. With an additional reversed cycle of flow counterbalanced capillary electrophoresis, any individual component in a sample mixture can be purified providing it can be separated in an electrophoresis system.}, keywords = {CAPILLARY-ZONE-ELECTROPHORESIS, CHIRAL SEPARATIONS, CHROMATOGRAPHY, ENANTIOMERS, FRACTION COLLECTOR, FREE-FLOW ELECTROPHORESIS, ISOELECTRIC-FOCUSING SEPARATION, MASS-SPECTROMETRY, MEMBRANE, PREPARATIVE-SCALE}, isbn = {0003-2700}, url = {://000221096800019}, author = {McLaren, D. G. and Chen, D. D. Y.} } @article {498, title = {An atmospheric pressure ion lens that improves nebulizer assisted electrospray ion sources}, journal = {Journal of the American Society for Mass Spectrometry}, volume = {13}, number = {8}, year = {2002}, note = {ISI Document Delivery No.: 588METimes Cited: 7Cited Reference Count: 27}, month = {Aug}, pages = {906-913}, type = {Article}, abstract = {An atmospheric pressure ion lens improves the performance and ease of use of a nebulizer assisted electrospray (ion spray) ion source. The lens is comprised of an oblong-shaped stainless steel ring attached to an external high voltage power supply. The lens is located near the tip of the conductive sprayer, and is maintained at a potential less than that of the sprayer. The ion lens improves the shape of the equipotential lines in the vicinity of the sprayer tip. This lens gives approximately a 2-fold reduction in the signal RSD, a 2-fold increase in the ion signal, an increase in the number of multiply charged ions, and a much broader range of usable sprayer positions. (C) 2002 American Society for Mass Spectrometry.}, keywords = {CAPILLARY-ZONE-ELECTROPHORESIS, DISSOCIATION, EVAPORATION, IDENTIFICATION, INDUCED, INTERFACE, IONIZATION MASS-SPECTROMETRY, JUNCTION, MECHANISM, PROTEIN-ANALYSIS, SHEATHLESS}, isbn = {1044-0305}, url = {://000177704600002}, author = {Schneider, B. B. and Douglas, D. J. and Chen, D. D. Y.} }