@article {2180,
	title = {Twenty years of interface development for capillary electrophoresis-electrospray ionization-mass spectrometry},
	journal = {Analytica Chimica Acta},
	volume = {627},
	number = {1},
	year = {2008},
	note = {ISI Document Delivery No.: 358IYTimes Cited: 22Cited Reference Count: 76Maxwell, E. Jane Chen, David D. Y.Sp. Iss. SI},
	month = {Oct},
	pages = {25-33},
	type = {Review},
	abstract = {Capillary electrophoresis-electrospray ionization-mass spectrometry has the potential to become a preferred tool for the analysis of biological mixtures and other complex samples. The development of improved interfaces in the past twenty years has been critical in demonstrating the feasibility of this technique. However, a compromise still exists between interfaces that give optimal performance and those that are practical for commercial applications. The first section of this review focuses on the technological advances in CE-ESI-MS as they relate to the key interface features for both sheath-flow and sheathless systems: delivery of the sheath liquid, shaping of the emitter tip, formation of electrical contact, and practicality in terms of ease of use and lifetime. In the second section, we review the fundamental processes that affect interface performance. Because of the complex natures of both capillary electrophoresis and electrospray ionization, flow rate, arrangement of the electrical circuit, electrochemistry, tip geometry and location of electrical contact must all be carefully managed in the design of a successful interface. (C) 2008 Elsevier B.V. All rights reserved.},
	keywords = {BEVELED EDGE, capillary electrophoresis, DESIGN, electrospray ionization, EMITTERS, FLOW NANOSPRAY, FUSED-SILICA CAPILLARY, interface development, JUNCTION INTERFACE, LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY, MASS SPECTROMETRY, MICRO-ELECTROSPRAY, SHEATHLESS CAPILLARY, ZONE-ELECTROPHORESIS},
	isbn = {0003-2670},
	url = {<Go to ISI>://000259911600003},
	author = {Maxwell, E. J. and Chen, D. D. Y.}
}
@article {1480,
	title = {Electrospray ionization source geometry for mass spectrometry: past, present, and future},
	journal = {Trac-Trends in Analytical Chemistry},
	volume = {25},
	number = {3},
	year = {2006},
	note = {ISI Document Delivery No.: 026CJTimes Cited: 34Cited Reference Count: 130},
	month = {Mar},
	pages = {243-256},
	type = {Review},
	abstract = {The geometry of an electrospray ion source plays important roles in the processes of analyte desolvation, ionization, transportation, and detection in a mass spectrometer. We provide a brief account of the scientific principles involved in developing an electrospray ion source, and in the various geometries used to improve the sensitivity of mass spectrometry. We also present some popular configurations currently available and outline future trends in this research area. (C) 2005 Elsevier Ltd. All rights reserved.},
	keywords = {ANALYSIS SYSTEMS, atmospheric pressure ionization, ATMOSPHERIC-PRESSURE, CAPILLARY-ZONE-ELECTROPHORESIS, CHARGED DROPLETS, commercial ion source design, electrospray ionization, ion source, ion source geometry, mass, MICRO-ELECTROSPRAY, MICROFLUIDIC DEVICES, NANOSCALE LIQUID-CHROMATOGRAPHY, PRESSURE ION LENS, PROTEIN IDENTIFICATION, SOLUTION FLOW-RATES, SPECTROMETRY},
	isbn = {0165-9936},
	url = {<Go to ISI>://000236314000013},
	author = {Manisali, I. and Chen, D. D. Y. and Schneider, B. B.}
}
