@article {ZHANG2018,
	title = {Electrochemical detection of microcystin-LR based on its deleterious effect on DNA},
	journal = {Talanta},
	volume = {185},
	year = {2018},
	month = {05/2018},
	pages = {405-410},
	type = {Research},
	keywords = {Cyanobacteria blooms, Deleterious effect, DNA, Electrochemical sensor, microcystin},
	issn = {0039-9140},
	doi = {https://doi.org/10.1016/j.talanta.2018.03.051},
	url = {http://www.sciencedirect.com/science/article/pii/S0039914018302911},
	author = {Keke Zhang and Huiying Ma and Ping Yan and Wenjun Tong and Xiaohua Huang and David D.Y. Chen}
}
@article {1489,
	title = {Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: Elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins},
	journal = {Journal of Molecular Biology},
	volume = {356},
	number = {1},
	year = {2006},
	note = {ISI Document Delivery No.: 007AFTimes Cited: 17Cited Reference Count: 42},
	month = {Feb},
	pages = {111-120},
	type = {Article},
	abstract = {The microcystins and nodularins are tumour promoting hepatotoxins that are responsible for global adverse human health effects and wildlife fatalities in countries where drinking water supplies contain cyanobacteria. The toxins function by inhibiting broad specificity Ser/Thr protein phosphatases in the host cells, thereby disrupting signal transduction pathways. A previous crystal structure of a microcystin bound to the catalytic subunit of protein phosphatase-1 (PP-1c) showed distinct changes in the active site region when compared with protein phosphatase-1 structures bound to other toxins. We have elucidated the crystal structures of the cyanotoxins, motuporin (nodularin-V) and dihydromicrocystin-LA bound to human protein phosphatase-1c (gamma isoform). The atomic structures of these complexes reveal the structural basis for inhibition of protein phosphatases by these toxins. Comparisons of the structures of the cyanobacterial toxin:phosphatase complexes explain the biochemical mechanism by which microcystins but not nodularins permanently modify their protein phosphatase targets by covalent addition to an active site cysteine residue. (c) 2005 Elsevier Ltd. All rights reserved.},
	keywords = {CATALYTIC SUBUNIT, COMPLEX, crystal structure, cyanobacteria, IN-VIVO, microcystin, MICROCYSTIN-LR, MOLECULAR-MECHANISMS, nodularin, POTENT, PROGRAM, TUMOR-PROMOTER, TYPE-1},
	isbn = {0022-2836},
	url = {<Go to ISI>://000234938600010},
	author = {Maynes, J. T. and Luu, H. A. and Cherney, M. M. and Andersen, R. J. and Williams, D. and Holmes, C. F. B. and James, M. N. G.}
}
@article {2702,
	title = {NEW NATURAL-PRODUCTS FROM MARINE-INVERTEBRATES},
	journal = {Gazzetta Chimica Italiana},
	volume = {123},
	number = {6},
	year = {1993},
	note = {ISI Document Delivery No.: LL566Times Cited: 3Cited Reference Count: 457TH INTERNATIONAL SYMP ON MARINE NATURAL PRODUCTS ( VII MANAPRO )JUL 05-10, 1992CAPRI, ITALY},
	month = {Jun},
	pages = {293-299},
	type = {Proceedings Paper},
	abstract = {Extracts of marine invertebrates collected in British Columbia and Papua New Guinea have been screened for the presence of cytotoxic and enzyme modulatory metabolites. Chemical examination of several active extracts has resulted in the identification of a number of novel natural products. These include: contignasterol, 2, a steroid having a cis C/D ring junction; pseudaxinellin, 5, a cyclic heptapeptide; trididemnic acids A, 7, and B, 8, two aromatic alkaloids from a tunicate; the rubrolides A, 13, to H, 20, a family of highly halogenated tunicate metabolites; and motuporin, 22, a cyclic pentapeptide that is the first marine representative of the microcystin class of hepatotoxic and tumor-promoting cyclic peptides. Microcystin LR has been found in marine shellfish for the first time and it has been implicated as the cause of a severe liver disease that occurs in netpen reared salmon in British Columbia.},
	keywords = {METABOLITES, microcystin, OKADAIC ACID, PEPTIDE, POTENT, SPONGE THEONELLA SP, TUMOR PROMOTER},
	isbn = {0016-5603},
	url = {<Go to ISI>://A1993LL56600001},
	author = {Andersen, R. J. and Burgoyne, D. L. and Williams, D. E. and Kong, F. M. and De Silva, E. D. and Miao, S. C. and Allen, T. M. and Holmes, C. F. B. and Chen, D. and Kent, M.}
}
