@article {2568,
	title = {Target-achieved propofol concentration during on-pump cardiac surgery: a pilot dose-finding study},
	journal = {Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie},
	volume = {56},
	number = {9},
	year = {2009},
	note = {ISI Document Delivery No.: 486HMTimes Cited: 0Cited Reference Count: 45Raedschelders, Koen Hui, Yu Laferlita, Bradley Luo, Tao Zhang, Hong Chen, David D. Y. Ansley, David M.},
	month = {Sep},
	pages = {658-666},
	type = {Article},
	abstract = {Propofol concentrations that produce laboratory-based cardioprotective effects are generally greater than those produced under routine anesthesia during cardiac surgery. It is unknown whether experimental cardioprotective propofol concentrations can routinely be achieved during cardiopulmonary bypass (CPB) using continuous infusion. Twenty-four patients scheduled for primary aortocoronary bypass grafting with CPB were allocated to receive one of three propofol infusion rates; 50, 100, or 150 mu g center dot A kg(-1) center dot A min(-1) in an open-label pilot study. Data were described using a line of best fit to derive an experimental clinical maneuver predicted to produce a whole blood concentration of 5 mu g center dot A mL(-1) at reperfusion. A predetermined interim analysis of 30 patients who were receiving the derived maneuver in an ongoing study was used to evaluate the maneuver. Cardiac index (CI), systemic vascular resistance index (SVRI), and left ventricular stroke work index (LVSWI) were recorded. The infusion rate-concentration curve had an equation of y = 0.215e (0.0279x) , where y represents the whole blood concentration and x represents the infusion rate (r (2) = 0.781). The predicted infusion rate to achieve a mean concentration of 5 mu g center dot A mL(-1) was 113 mu g center dot A kg(-1) center dot A min(-1). The nearest practical rate is 120 mu g center dot A kg(-1) center dot A min(-1), producing a concentration of 5.39 (1.45) mu g center dot A mL(-1). The values for CI, SVRI, and LVSWI were similar between groups at corresponding time periods. An infusion rate of 120 mu g center dot A kg(-1) center dot A min(-1) is clinically practical and capable of achieving experimental cardioprotective propofol concentrations at reperfusion.},
	keywords = {ANESTHETICS, antioxidant capacity, cell, CORONARY SURGERY, ISCHEMIA-REPERFUSION INJURY, K-ATP CHANNELS, MYOCARDIAL-FUNCTION, NORMOTHERMIC CARDIOPULMONARY BYPASS, PERMEABILITY TRANSITION, PLASMA-CONCENTRATIONS, RAT HEARTS, VOLATILE},
	isbn = {0832-610X},
	url = {<Go to ISI>://000269186900005},
	author = {Raedschelders, K. and Hui, Y. and Laferlita, B. and Luo, T. and Zhang, H. and Chen, D. D. Y. and Ansley, D. M.}
}
@article {4255,
	title = {Complementary use of capillary gas chromatography mass spectrometry (ion trap) and gas chromatography inductively coupled plasma mass spectrometry for the speciation of volatile antimony, tin and bismuth compounds in landfill and fermentation gases},
	journal = {Analyst},
	volume = {123},
	number = {5},
	year = {1998},
	note = {ISI Document Delivery No.: ZN568Times Cited: 40Cited Reference Count: 183rd International Symposium on Speciation of Trace Elements in Biological, Environmental and Toxicological SciencesSEP 15-19, 1997PORT DOUGLAS, AUSTRALIAUniv New S Wales, Natl Inst Occupat Hlth, McMaster Univ, Inst Environ \& Hlth, MAFF, CSL, Food Sci Lab},
	month = {May},
	pages = {815-820},
	type = {Proceedings Paper},
	abstract = {ICP-MS is very sensitive and has limited matrix effects when used as an element-specific detector for GC in order to identify volatile metal or metalloid species, GC-MS is not very sensitive or selective in the electron ionization (EI) mode, but provides molecular information about volatile species. In this work, an ion trap EI-MS-MS and an ICP-MS system were used as two different detectors for the same GC system to provide complementary information about volatile organometallic species in the complex matrices of landfill and sewage sludge fermentation gases. A simple robust GC separation method with cryotrapping was adequate for the separation of the different metal(loid) containing volatile compounds, and was directly coupled to the ICP-MS system, In addition, gas samples from this GC system were collected in evacuated vials. These fractions were further separated on a capillary column and detected in an ion trap mass spectrometer. For the first time, parent ions, fragmentation patterns, isotopic ratios for Sb and Sn, and MS-MS data were used to identify positively Me3Sb, Me4Sn and Et2Me2Sn in landfill gas and Me3Sb and Me3Bi in fermentation gas.},
	keywords = {ELEMENTS, fermentation gas, gas chromatography-inductively coupled, ion trap mass spectrometry, landfill gas, MASS SPECTROMETRY, METAL, MS, organometallics, ORGANOTIN COMPOUNDS, trimethylbismuthine, trimethylstibine, VOLATILE, WASTE DEPOSITS},
	isbn = {0003-2654},
	url = {<Go to ISI>://000073658900010},
	author = {Feldmann, J. and Koch, I. and Cullen, W. R.}
}
