@article {2388,
	title = {Potential new inorganic antitumour agents from combining the anticancer traditional Chinese medicine (TCM) liriodenine with metal ions, and DNA binding studies},
	journal = {Dalton Transactions},
	number = {2},
	year = {2009},
	note = {ISI Document Delivery No.: 385IHTimes Cited: 6Cited Reference Count: 68Chen, Zhen-Feng Liu, Yan-Cheng Liu, Li-Min Wang, Heng-Shan Qin, San-Hai Wang, Bo-Long Bian, He-Dong Yang, Bin Fun, Hoong-Kun Liu, Hua-Gang Liang, Hong Orvig, Chris},
	pages = {262-272},
	type = {Article},
	abstract = {Liriodenine (L), an active component of the anticancer traditional Chinese medicine (TCM), was isolated from Zanthoxylum nitidum. Its reactions with Pt(II) and Ru(II) afforded three metal complexes: cis-[PtCl2(L)] (1), cis-[PtCl2(L)(DMSO)] (2), and cis-[RuCl2(L)(DMSO)(2)]center dot 1.5H(2)O (3), the crystal structures of L, 2 and 3 were determined by single-crystal X-ray diffraction methods. These complexes were fully characterized by elemental analysis, IR spectrophotometry, H-1 and C-13 NMR spectroscopies, and ES mass spectrometry. The in vitro cytotoxicity of L and complexes 1-3 against 11 human tumour cell lines was assayed. The metal-based compounds exhibit enhanced cytotoxicity vs. free L, suggesting that these compounds display synergy in the combination of metal ions and liriodenine. The binding properties of L and its complexes 1-3 to ct-DNA were investigated through UV-vis, fluorescence, CD spectra, viscosity and agarose gels electrophoretic measurements.},
	keywords = {AFFINITY, ALKALOIDS, CISPLATIN, CYTOTOXIC ACTIVITY, DRUGS, FLUORESCENCE, IN-VITRO, PLATINUM(II) COMPLEXES, RUTHENIUM(II) COMPLEXES, TOPOISOMERASE-II},
	isbn = {1477-9226},
	url = {<Go to ISI>://000261807400006},
	author = {Chen, Z. F. and Liu, Y. C. and Liu, L. M. and Wang, H. S. and Qin, S. H. and Wang, B. L. and Bian, H. D. and Yang, B. and Fun, H. K. and Liu, H. G. and Liang, H. and Orvig, Chris}
}
@article {1407,
	title = {Sulfated meroterpenoids from the Brazilian sponge Callyspongia sp. are inhibitors of the antileishmaniasis target adenosine phosphoribosyl transferase},
	journal = {Journal of Organic Chemistry},
	volume = {71},
	number = {23},
	year = {2006},
	note = {ISI Document Delivery No.: 101QKTimes Cited: 14Cited Reference Count: 23Gray, Christopher A. de Lira, Simone P. Silva, Marcio Pimenta, Eli F. Thiemann, Otavio H. Oliva, Glaucius Hajdu, Eduardo Andersen, Raymond J. Berlinck, Roberto G. S.},
	month = {Nov},
	pages = {8685-8690},
	type = {Article},
	abstract = {Three new disulfated meroterpenoids, ilhabelanol (1), ilhabrene (2), and isoakaterpin (3), have been isolated from extracts of the Brazilian marine sponge Callyspongia sp. Isoakaterpin (3) inhibits Leishmania spp. adenosine phosphoribosyl transferase with an IC50 of 1.05 mu M. The structures of 1, 2, and 3 were elucidated by analysis of one- and two-dimensional NMR data. Ilhabelanol (1) and ilhabrene (2) both have unprecedented meroterpenoid carbon skeletons.},
	keywords = {AKA ADOCIA SP, AKATERPIN, chemotherapy, DRUGS, HEXAPRENOID HYDROQUINONES, LEISHMANIASIS, NATURAL-PRODUCTS, TOXICLONA-TOXIUS},
	isbn = {0022-3263},
	url = {<Go to ISI>://000241755300001},
	author = {Gray, C. A. and de Lira, S. P. and Silva, M. and Pimenta, E. F. and Thiemann, O. H. and Oliva, G. and Hajdu, E. and Andersen, R. J. and Berlinck, R. G. S.}
}
@article {5149,
	title = {Unprecedented sugar-dependent in vivo antitumor activity of carbohydrate-pendant cis-diamminedichloroplatinum(II) complexes},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {11},
	number = {23},
	year = {2001},
	note = {ISI Document Delivery No.: 494DZTimes Cited: 23Cited Reference Count: 15},
	month = {Dec},
	pages = {3045-3047},
	type = {Article},
	abstract = {Eight carbohydrate-pendant platinum(II) complexes have been synthesized from carbohydrate-diamine conjugates. D-Glucose, D-mannose, D-galactose, D-xylose, and L-glucose are attached to the dichloroplatinum(II) moiety by 1,3- or 1,2-diaminopropane chelates through with an O-glycoside bond. All the carbohydrate moieties reduced the toxicity inherent with platinum(II) complexes. (C) 2001 Elsevier Science Ltd. All rights reserved.},
	keywords = {CISPLATIN, DNA, DRUGS, MOLECULES},
	isbn = {0960-894X},
	url = {<Go to ISI>://000172267600013},
	author = {Mikata, Y. and Shinohara, Y. and Yoneda, K. and Nakamura, Y. and Brudzinska, I. and Tanase, T. and Kitayama, T. and Takagi, R. and Okamoto, T. and Kinoshita, I. and Doe, M. and Orvig, Chris and Yano, S.}
}
@article {4638,
	title = {Porphyrins incorporating heterocyclic N-oxides: (oxidopyridyl)porphyrins, porphyrin-N-oxides, and a tirapazamine-porphyrin conjugate},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {77},
	number = {2},
	year = {1999},
	note = {ISI Document Delivery No.: 188AZTimes Cited: 9Cited Reference Count: 41},
	month = {Feb},
	pages = {182-198},
	type = {Article},
	abstract = {{Porphyrins containing one to four 3-pyridyl groups as meso-substituents were synthesized via a mixed aldehyde condensation, and then "N-oxidized" with m-chloroperbenzoic acid to produce five novel (oxidopyridyl) porphyrins and seven porphyrin-N-oxides which were characterized by analysis and spectroscopic methods, especially NMR; an X-ray crystal structure of 5-(1-oxido-4-pyridyl)-10, 15,20-triphenylporphyrin was also obtained. Crystals of (oxidopyridyl)triphenylporphyrin are tetragonal},
	keywords = {(oxidopyridyl)porphyrins, ANTICANCER, BIOREDUCTIVE DRUGS, DESIGN, DRUGS, FUNCTIONAL-GROUPS, NICKEL(II), PHENYL, PHOTODYNAMIC THERAPY, porphyrin-N-oxides, tirapazamine},
	isbn = {0008-4042},
	url = {<Go to ISI>://000079823200003},
	author = {Posakony, J. J. and Pratt, R. C. and Rettig, S. J. and James, Brian R. and Skov, K. A.}
}
