@article {2568,
	title = {Target-achieved propofol concentration during on-pump cardiac surgery: a pilot dose-finding study},
	journal = {Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie},
	volume = {56},
	number = {9},
	year = {2009},
	note = {ISI Document Delivery No.: 486HMTimes Cited: 0Cited Reference Count: 45Raedschelders, Koen Hui, Yu Laferlita, Bradley Luo, Tao Zhang, Hong Chen, David D. Y. Ansley, David M.},
	month = {Sep},
	pages = {658-666},
	type = {Article},
	abstract = {Propofol concentrations that produce laboratory-based cardioprotective effects are generally greater than those produced under routine anesthesia during cardiac surgery. It is unknown whether experimental cardioprotective propofol concentrations can routinely be achieved during cardiopulmonary bypass (CPB) using continuous infusion. Twenty-four patients scheduled for primary aortocoronary bypass grafting with CPB were allocated to receive one of three propofol infusion rates; 50, 100, or 150 mu g center dot A kg(-1) center dot A min(-1) in an open-label pilot study. Data were described using a line of best fit to derive an experimental clinical maneuver predicted to produce a whole blood concentration of 5 mu g center dot A mL(-1) at reperfusion. A predetermined interim analysis of 30 patients who were receiving the derived maneuver in an ongoing study was used to evaluate the maneuver. Cardiac index (CI), systemic vascular resistance index (SVRI), and left ventricular stroke work index (LVSWI) were recorded. The infusion rate-concentration curve had an equation of y = 0.215e (0.0279x) , where y represents the whole blood concentration and x represents the infusion rate (r (2) = 0.781). The predicted infusion rate to achieve a mean concentration of 5 mu g center dot A mL(-1) was 113 mu g center dot A kg(-1) center dot A min(-1). The nearest practical rate is 120 mu g center dot A kg(-1) center dot A min(-1), producing a concentration of 5.39 (1.45) mu g center dot A mL(-1). The values for CI, SVRI, and LVSWI were similar between groups at corresponding time periods. An infusion rate of 120 mu g center dot A kg(-1) center dot A min(-1) is clinically practical and capable of achieving experimental cardioprotective propofol concentrations at reperfusion.},
	keywords = {ANESTHETICS, antioxidant capacity, cell, CORONARY SURGERY, ISCHEMIA-REPERFUSION INJURY, K-ATP CHANNELS, MYOCARDIAL-FUNCTION, NORMOTHERMIC CARDIOPULMONARY BYPASS, PERMEABILITY TRANSITION, PLASMA-CONCENTRATIONS, RAT HEARTS, VOLATILE},
	isbn = {0832-610X},
	url = {<Go to ISI>://000269186900005},
	author = {Raedschelders, K. and Hui, Y. and Laferlita, B. and Luo, T. and Zhang, H. and Chen, D. D. Y. and Ansley, D. M.}
}
@article {1349,
	title = {Nonmechanical protein can have significant mechanical stability},
	journal = {Angewandte Chemie-International Edition},
	volume = {45},
	number = {4},
	year = {2006},
	note = {ISI Document Delivery No.: 004RFTimes Cited: 30Cited Reference Count: 44},
	pages = {642-645},
	type = {Article},
	keywords = {ADHESION, cell, DISULFIDE BONDS, DYNAMICS, ELASTICITY, mechanical properties, microscopy, MOLECULE FORCE-SPECTROSCOPY, protein unfolding, resistance, scanning probe microscopy, SIMULATION, SINGLE PROTEIN, single-molecule studies, TITIN IMMUNOGLOBULIN DOMAINS},
	isbn = {1433-7851},
	url = {<Go to ISI>://000234769200026},
	author = {Cao, Y. and Lam, C. and Wang, M. J. and Li, H. B.}
}
@article {641,
	title = {The synthesis, structural characterization, and in vitro anti-cancer activity of chloro(p-cymene) complexes of ruthenium(II) containing a disulfoxide ligand},
	journal = {Inorganica Chimica Acta},
	volume = {352},
	year = {2003},
	note = {ISI Document Delivery No.: 711FATimes Cited: 39Cited Reference Count: 47},
	month = {Aug},
	pages = {238-246},
	type = {Article},
	abstract = {Two diruthenium(II) complexes [RuCl2(p-cymene)](2)(mu-BESE) (1), [RuCl2(p-cymene)](2)(mu-BESP) (2), and the mononuclear salt [RuCl(p-cymene)(BESE)]PF6 (3), containing the disulfoxides BESE and BESP, were synthesized and characterized by elemental analysis, and NMR and IR spectroscopies, and were shown to contain S-bound sulfoxide groups; the disulfoxides are EtS(O)(CH2)(n) S(O)Et, where n = 2 (BESE) or 3 (BESP). Complexes 1 and 3 were also characterized by X-ray crystallography. Preliminary in vitro tests of I and 3 were conducted using the MTT assay, which measures mitochondrial dehydrogenase activity as an indication of cell viability; these complexes showed in vitro anti-cancer activity against a human mammary cancer cell line (MDA-MB-435s) with IC50 values of 360 and 55 muM, respectively. (C) 2003 Elsevier B.V. All rights reserved.},
	keywords = {anti-cancer activity, arene complexes, CANCER, cell, COMPLEX, COORDINATION, crystal structures, CRYSTAL-STRUCTURE, DIMETHYL-SULFOXIDE LIGAND, DIRUTHENIUM(II), disulfoxide ligands, INHIBITION, p-Cymene complexes, RADIOSENSITIZING ACTIVITY, ruthenium complexes, SOLUTION CHEMISTRY},
	isbn = {0020-1693},
	url = {<Go to ISI>://000184727900029},
	author = {Huxham, L. A. and Cheu, E. L. S. and Patrick, B. O. and James, Brian R.}
}
@article {4920,
	title = {Electrospray ionization of alkali and alkaline earth metal species. Electrochemical oxidation and pH effects},
	journal = {Journal of Mass Spectrometry},
	volume = {35},
	number = {8},
	year = {2000},
	note = {ISI Document Delivery No.: 347MUTimes Cited: 7Cited Reference Count: 49},
	month = {Aug},
	pages = {981-989},
	type = {Article},
	abstract = {The utility of electrospray ionization mass spectrometry (ESI-MS) for characterizing dissolved metal species has generated considerable interest in the use of this technique for metal speciation, However, the development of accurate speciation methods based on ESI-R;IS requires a detailed understanding of the mechanisms by which dissolved metal species are ionized during electrospray. We report how the analysis of alkali and alkaline earth metal species pro,ides new information about some of the processes that affect electrospray ion yield. Selected metal ions and organic ligands were combined in 50:50 water-acetonitrile buffered with acetic acid or ammonium acetate and analyzed by flow injection ESI-MS using mild electrospray conditions. Species formed by alkali metal ions with thiol and oxygen-donating ligands were detected in acidic and neutral pH solutions. Electrochemical oxidation of N,N-diethyldithiocarbamate and glutathione during electrospray was indicated by detection of the corresponding disulfides as protonated or alkali metal species, The extent of ligand oxidation depended on solution pH and the dissociation constant of the thiol group, Tandem mass spectrometric experiments suggested that radical cations such as [NaL](+.) (where L = N,N -diethyldithiocarbamate) can be generated by in-source fragmentation of disulfide species. Greater complexation of alkali metals at neutral pH tvas indicated by a corresponding decrease in the relative abundance of the free metal ion, The number of alkali metal ions bound by glutathione and phthalic acid also increased with increasing pH, in accordance with thermodynamic equilibrium theory. Alkaline earth metal species were detected only in acidic solutions, the absence of 8-hydroxyquinoline complexes being attributed to their relative instability and subsequent dissociation during electrospray, Hence, accurate speciation by ESI-MS depends on experimental conditions and the intrinsic properties of each analyte, Copyright (C) 2000 John Wiley \&; Sons, Ltd.},
	keywords = {cell, COMPLEXES, electrochemical oxidation, ELECTROPHORESIS, electrospray ionization, ION-TRAP, MASS-SPECTROMETRY, metal speciation, OLIGONUCLEOTIDES, PEPTIDES, pH effects, PROTEINS, STOICHIOMETRY, thiol ligands, WATER},
	isbn = {1076-5174},
	url = {<Go to ISI>://000088934400006},
	author = {Ross, A. R. S. and Ikonomou, M. G. and Orians, K. J.}
}
@article {4689,
	title = {Undercarboxylation of recombinant prothrombin revealed by analysis of gamma-carboxyglutamic acid using capillary electrophoresis and laser-induced fluorescence},
	journal = {Febs Letters},
	volume = {445},
	number = {2-3},
	year = {1999},
	note = {ISI Document Delivery No.: 175YCTimes Cited: 6Cited Reference Count: 37},
	month = {Feb},
	pages = {256-260},
	type = {Article},
	abstract = {The gamma-carboxyglutamic acid (Gla) content of several variants of human prothrombin has been measured by using capillary electrophoresis and laser-induced fluorescence (CE-LIF). Both plasma-derived prothrombin and recombinant prothrombin contain ten residues of Gla per molecule of protein. In contrast, a variant of human prothrombin (containing the second kringle domain of bovine prothrombin) was separated into two populations that differed in their Gla content. Direct measurement of the Gla content showed an association with the presence or absence of the calcium-dependent conformational change that is required for prothombinase function. Thus, the CE-LIF assay is useful in determining the carboxylation status of recombinant proteins. (C) 1999 Federation of European Biochemical Societies.},
	keywords = {baby hamster kidney, calcium, capillary electrophoresis, cell, EXPRESSION, FACTOR-X, gamma carboxy glutamic acid, GLUTAMIC-ACID, HUMAN PROTEIN-C, LASER-INDUCED FLUORESCENCE, METAL, PHOSPHOLIPID-BINDING-PROPERTIES, PROTHROMBIN, PURIFICATION, recombinant protein, RESIDUES, VITAMIN-K},
	isbn = {0014-5793},
	url = {<Go to ISI>://000079122800007},
	author = {Vo, H. C. and Britz-McKibbin, P. and Chen, D. D. Y. and MacGillivray, R. T. A.}
}
@article {7174,
	title = {COMPARISONS BETWEEN A GRIMM-TYPE GLOW-DISCHARGE AND A JET-ASSISTED GLOW-DISCHARGE SOURCE VIEWED AXIALLY AND LATERALLY},
	journal = {Spectrochimica Acta Part B-Atomic Spectroscopy},
	volume = {47},
	number = {13},
	year = {1992},
	note = {ISI Document Delivery No.: JY641Times Cited: 10Cited Reference Count: 29},
	month = {Nov},
	pages = {1435-1446},
	type = {Article},
	abstract = {Comparisons have been made between three types of glow discharge with regard to analytical performance. These glow discharge types include a Grimm-type glow discharge, a jet-assisted glow discharge viewed axially to the jet-assisted plasma plume and the same discharge viewed laterally 25 mm from the sample surface where its characteristics are sufficiently different to warrant re-classification. The axially viewed, jet-assisted glow discharge provides the highest detection power, but laterally viewing allows the potential for greater dynamic range, greater freedom from spectral interferences and a detection power comparable to the Grimm-type glow discharge. This makes lateral viewing of the jet-assisted plasma plume attractive for simultaneous multi-element applications.},
	keywords = {ATOMIC-ABSORPTION SPECTROMETRY, ATOMIZATION, CATHODIC-SPUTTERING ATOMIZER, cell, LAMP, SAMPLES, SPECTROSCOPY},
	isbn = {0584-8547},
	url = {<Go to ISI>://A1992JY64100002},
	author = {Banks, P. R. and Blades, M. W.}
}
@article {6986,
	title = {SIMPLE PHYSICAL MODELS FOR COULOMB-INDUCED FREQUENCY-SHIFTS AND COULOMB-INDUCED INHOMOGENEOUS BROADENING FOR LIKE AND UNLIKE IONS IN FOURIER-TRANSFORM ION-CYCLOTRON RESONANCE MASS-SPECTROMETRY},
	journal = {Rapid Communications in Mass Spectrometry},
	volume = {5},
	number = {10},
	year = {1991},
	note = {ISI Document Delivery No.: GJ483Times Cited: 54Cited Reference Count: 20},
	month = {Oct},
	pages = {450-455},
	type = {Article},
	abstract = {Two simple models which correspond more closely to physical reality than some prior models are proposed to account for the Coulomb-induced frequency shifts to lower frequency, which have been observed in Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry. The first model consists of two different-mass point charges which undergo cyclotron orbits with the same orbit centers at their respective cyclotron frequencies. The model predicts that each excited cyclotron motion should induce a negative frequency shift in the other{\textquoteright}s cyclotron motion. The model predicts a zero frequency shift for ions of the same mass. The physical basis for the Coulomb-induced shift is most easily seen in a coordinate frame which rotates at the cyclotron motion of the ion whose frequency is shifted. It is noted that a prior model for Coulomb-induced frequency shifts is more appropriate for scanning ICR than FT-ICR and the reason is described for the correctness of the predictions of this less appropriate model. A second model, the line model, is created by extension of the point model. The line model gives rise to a position-dependent frequency shift which is synonymous with inhomogeneous Coulomb broadening. When a non-quadrupolar electrostatic trapping field is included in the model, {\textquoteright}like{\textquoteright} ions become {\textquoteright}unlike{\textquoteright} and Coulomb-shifting and Coulomb-broadening apply, as for {\textquoteright}like{\textquoteright} ions. The analysis predicts that ICR cells which are designed to have negligible trapping fields over most of their volume will be less sensitive to Coulomb shifting/broadening than ordinary ICR cells.},
	keywords = {cell, SPACE-CHARGE},
	isbn = {0951-4198},
	url = {<Go to ISI>://A1991GJ48300005},
	author = {Chen, S. P. and Comisarow, M. B.}
}
