@article {4659,
	title = {Measurement of some small-molecule and peptide neurotransmitters in-vitro using a fiber-optic probe with pulsed ultraviolet resonance Raman spectroscopy},
	journal = {Journal of Neuroscience Methods},
	volume = {92},
	number = {1-2},
	year = {1999},
	note = {ISI Document Delivery No.: 262ADTimes Cited: 13Cited Reference Count: 22},
	month = {Oct},
	pages = {15-24},
	type = {Article},
	abstract = {Many techniques have been developed to investigate the chemistry associated with brain activity. These techniques generally fall into two categories: fast techniques with species-limited sensitivity; and generally slower techniques with broader species sensitivity. Therefore, a need exists for a fast, minimally invasive technique that is sensitive to a wide array of biologically relevant compounds in order to measure chemical brain events in real time. The work presented here describes the development of a novel spectroscopic neurotransmitter probe for the rapid and simultaneous detection of a variety of neurotransmitters. A fiber-optic-linked Raman and tunable ultraviolet resonance Raman system was assembled with custom designed optical fiber probes. Using this system, the ultraviolet resonance Raman spectra of some small-molecule and peptide neurotransmitters were measured in-vitro with a fiber-optic probe and are reported here for the first time. The probe has furthermore been used to measure neurotransmitter secretions obtained from depolarized rat pheochromocytoma (PC12) cells. These results demonstrate the general utility of this approach which, due to the fiber-optic implementation, could potentially also be applied to in-vivo neurotransmitter determinations. (C) 1999 Elsevier Science B.V. All rights reserved.},
	keywords = {CELLS, fiber, neuropeptide, neurotransmitter, optical, resonance Raman spectroscopy},
	isbn = {0165-0270},
	url = {<Go to ISI>://000084042800003},
	author = {Schulze, H. G. and Greek, L. S. and Barbosa, C. J. and Blades, M. W. and Gorzalka, B. B. and Turner, R. F. B.}
}
@article {4659,
	title = {Measurement of some small-molecule and peptide neurotransmitters in-vitro using a fiber-optic probe with pulsed ultraviolet resonance Raman spectroscopy},
	journal = {Journal of Neuroscience Methods},
	volume = {92},
	number = {1-2},
	year = {1999},
	note = {ISI Document Delivery No.: 262ADTimes Cited: 13Cited Reference Count: 22},
	month = {Oct},
	pages = {15-24},
	type = {Article},
	abstract = {Many techniques have been developed to investigate the chemistry associated with brain activity. These techniques generally fall into two categories: fast techniques with species-limited sensitivity; and generally slower techniques with broader species sensitivity. Therefore, a need exists for a fast, minimally invasive technique that is sensitive to a wide array of biologically relevant compounds in order to measure chemical brain events in real time. The work presented here describes the development of a novel spectroscopic neurotransmitter probe for the rapid and simultaneous detection of a variety of neurotransmitters. A fiber-optic-linked Raman and tunable ultraviolet resonance Raman system was assembled with custom designed optical fiber probes. Using this system, the ultraviolet resonance Raman spectra of some small-molecule and peptide neurotransmitters were measured in-vitro with a fiber-optic probe and are reported here for the first time. The probe has furthermore been used to measure neurotransmitter secretions obtained from depolarized rat pheochromocytoma (PC12) cells. These results demonstrate the general utility of this approach which, due to the fiber-optic implementation, could potentially also be applied to in-vivo neurotransmitter determinations. (C) 1999 Elsevier Science B.V. All rights reserved.},
	keywords = {CELLS, fiber, neuropeptide, neurotransmitter, optical, resonance Raman spectroscopy},
	isbn = {0165-0270},
	url = {<Go to ISI>://000084042800003},
	author = {Schulze, H. G. and Greek, L. S. and Barbosa, C. J. and Blades, M. W. and Gorzalka, B. B. and Turner, R. F. B.}
}
@article {3685,
	title = {Rational design of fiber-optic probes for visible and pulsed-ultraviolet resonance Raman spectroscopy},
	journal = {Applied Optics},
	volume = {35},
	number = {21},
	year = {1996},
	note = {ISI Document Delivery No.: VA608Times Cited: 16Cited Reference Count: 24OSA 1995 Annual Meeting1995PORTLAND, OROpt Soc Amer},
	month = {Jul},
	pages = {4086-4095},
	type = {Proceedings Paper},
	abstract = {The investigated the performance of fiber-optic resonance Raman probes with a series of experiments to determine the working curves of such probes using model analytes and to investigate the effects of absorbing media. A computer model designed to simulate these experiments is presented, and numerical results are found to be in agreement with the experimental data. Design considerations resulting from these studies are discussed, and novel designs for overcoming problems of coupling efficiency, damage threshold, and sensitivity in absorbing samples are presented. These findings are applied to the design of fiber-optic probes for ultraviolet resonance Raman spectroscopy involving nanosecond pulsed-ultraviolet excitation (225 and 266 nm). These probes have been used to collect what is, to our knowledge, the first reported fiber-optic-linked ultraviolet resonance Raman spectra of tryptophan and DNA. (C) 1996 Optical Society of America},
	keywords = {AROMATIC-AMINO-ACIDS, EFFECTIVE DEPTH, fiber-optic probes, LASER EXCITATION, numerical modeling of, optical fibers, OPTIMIZATION, Raman spectroscopy, remote Raman, resonance Raman spectroscopy, SCATTERING, sensors, SPECTROSCOPY},
	isbn = {0003-6935},
	url = {<Go to ISI>://A1996VA60800014},
	author = {Greek, L. S. and Schulze, H. G. and Haynes, C. A. and Blades, M. W. and Turner, R. F. B.}
}
@article {3685,
	title = {Rational design of fiber-optic probes for visible and pulsed-ultraviolet resonance Raman spectroscopy},
	journal = {Applied Optics},
	volume = {35},
	number = {21},
	year = {1996},
	note = {ISI Document Delivery No.: VA608Times Cited: 16Cited Reference Count: 24OSA 1995 Annual Meeting1995PORTLAND, OROpt Soc Amer},
	month = {Jul},
	pages = {4086-4095},
	type = {Proceedings Paper},
	abstract = {The investigated the performance of fiber-optic resonance Raman probes with a series of experiments to determine the working curves of such probes using model analytes and to investigate the effects of absorbing media. A computer model designed to simulate these experiments is presented, and numerical results are found to be in agreement with the experimental data. Design considerations resulting from these studies are discussed, and novel designs for overcoming problems of coupling efficiency, damage threshold, and sensitivity in absorbing samples are presented. These findings are applied to the design of fiber-optic probes for ultraviolet resonance Raman spectroscopy involving nanosecond pulsed-ultraviolet excitation (225 and 266 nm). These probes have been used to collect what is, to our knowledge, the first reported fiber-optic-linked ultraviolet resonance Raman spectra of tryptophan and DNA. (C) 1996 Optical Society of America},
	keywords = {AROMATIC-AMINO-ACIDS, EFFECTIVE DEPTH, fiber-optic probes, LASER EXCITATION, numerical modeling of, optical fibers, OPTIMIZATION, Raman spectroscopy, remote Raman, resonance Raman spectroscopy, SCATTERING, sensors, SPECTROSCOPY},
	isbn = {0003-6935},
	url = {<Go to ISI>://A1996VA60800014},
	author = {Greek, L. S. and Schulze, H. G. and Haynes, C. A. and Blades, M. W. and Turner, R. F. B.}
}
