@article {2547,
	title = {Design and Synthesis of Novel Phenothiazinium Photosensitiser Derivatives},
	journal = {European Journal of Organic Chemistry},
	number = {16},
	year = {2009},
	note = {ISI Document Delivery No.: 452FITimes Cited: 1Cited Reference Count: 39New, Olivia M. Dolphin, David},
	month = {Jun},
	pages = {2675-2686},
	type = {Article},
	abstract = {A high-yielding approach towards N-(2-aminoethyl)-Azure B has been established and extended towards the preparation of a functionalized peptide-dye synthetic precursor; Boc-protected 3-(alkylamino)phenothiazin-5-ium TFA. This has been utilized in a series of reactions with various amines towards nine novel 3,7-disubstituted phenothiazin-5-ium derivatives. Cleavage of the Boc group in the 3,7-disubstituted salts allowed a further seven novel dyes to be prepared and these have been utilized in a practical methodology designed for the synthesis of 13 novel phenothiazine-peptide conjugates. These peptide-photosensitizer vectors consist of a covalent attachment of a tethered dye to various protected amino acid moieties including the cell-penetrating peptide (CPP) octa-arginine and exhibit intense absorption maxima in the 623650 nm regions of the visible spectrum. The main goal of the studies is the design of cell-compatible photosensitisers that may be employed in photodynamic therapy. ((C) Wiley-VCH Verlag GmbH \& Co. KGaA, 69451 Weinheim, Germany, 2009)},
	keywords = {AMINATION, ANALOGS, Azure B, BENZOPHENOTHIAZINE, Cell-penetrating peptide, CELLULAR DELIVERY, Dye-peptide conjugate, Electronic spectra, METHYLENE-BLUE, Phenothiazine dye, PHOTODYNAMIC THERAPY, SERIES, TRANSDUCTION, TRANSLOCATION, TRANSPORTERS, TUMORS},
	isbn = {1434-193X},
	url = {<Go to ISI>://000266525100010},
	author = {New, O. M. and Dolphin, D.}
}
@article {2298,
	title = {Biomimetic synthesis of the IDO inhibitors exiguamine A and B},
	journal = {Nature Chemical Biology},
	volume = {4},
	number = {9},
	year = {2008},
	note = {ISI Document Delivery No.: 339SNTimes Cited: 7Cited Reference Count: 19Volgraf, Matthew Lumb, Jean-Philip Brastianos, Harry C. Carr, Gavin Chung, Marco K. W. Muenzel, Martin Mauk, A. Grant Andersen, Raymond J. Trauner, Dirk},
	month = {Sep},
	pages = {535-537},
	type = {Article},
	abstract = {Biomimetic synthesis is an attempt to assemble natural products along biosynthetic lines without recourse to the full enzymatic machinery of nature. We exemplify this with a total synthesis of exiguamine A and the newly isolated natural product exiguamine B. The most noteworthy feature of this work is an oxidative endgame drawing from the complex chemistry of catecholamines, which allows for ready access to a new class of nanomolar indoleamine-2,3-dioxygenase inhibitors.},
	keywords = {3-DIOXYGENASE, ANALOGS, CANCER, CASCADE, CELLS, ELECTROCYCLIZATIONS, EXPRESSION, INDOLEAMINE 2},
	isbn = {1552-4450},
	url = {<Go to ISI>://000258597700011},
	author = {Volgraf, M. and Lumb, J. P. and Brastianos, H. C. and Carr, G. and Chung, M. K. W. and Munzel, M. and Mauk, A. G. and Andersen, R. J. and Trauner, D.}
}
@article {2183,
	title = {Intraannular Savige-Fontana reaction: One-step conversion of one class of monocyclic peptides into another class of bicyclic peptides},
	journal = {Chemistry-a European Journal},
	volume = {14},
	number = {11},
	year = {2008},
	note = {ISI Document Delivery No.: 291XITimes Cited: 1Cited Reference Count: 34May, Jonathan P. Perrin, David M.},
	pages = {3404-3409},
	type = {Article},
	abstract = {Cyclisation and cross-linking strategies are important for the synthesis of cyclic and bicyclic peptides. These macrolactams are of great interest due to their increased biological activity compared to linear analogues. Herein, we describe the synthesis of a cyclic peptide containing an Hpi toxicophore, reminiscent of phakellistatins and omphalotins. The first intraannular cross-linking of such a peptide is then presented: using neat TFA to catalyse a Savige-Fontana tryptathionylation, the Hpi-containing peptide is converted to a bicyclic amatoxin analogue. As such, this methodology represents an efficient cyclisation method for cross-linking peptides and exposes a heretofore unrealised relationship between two different classes of peptide natural products. This finding increases the degree of potential chemical space for library generation.},
	keywords = {2-CHLOROTRITYL CHLORIDE, 2-THIOETHER DERIVATIVES, amatoxin, ANALOGS, CROSS-LINKING, CYSTEINE SULFHYDRYL-GROUPS, ILE3-AMANINAMIDE, indole, ISOPHAKELLISTATIN-3, natural products, OXIDATION, PEPTIDES, PHALLOTOXINS, RNA POLYMERASE-II, TRYPTOPHAN},
	isbn = {0947-6539},
	url = {<Go to ISI>://000255230200019},
	author = {May, J. P. and Perrin,David M.}
}
@article {1482,
	title = {Liphagal, a selective inhibitor of PI3 kinase alpha isolated from the sponge Aka coralliphaga: Structure elucidation and biomimetic synthesis},
	journal = {Organic Letters},
	volume = {8},
	number = {2},
	year = {2006},
	note = {ISI Document Delivery No.: 003BZTimes Cited: 31Cited Reference Count: 15},
	month = {Jan},
	pages = {321-324},
	type = {Article},
	abstract = {Liphagal (1), a selective inhibitor of PI3K alpha, has been isolated from the marine sponge Aka coralliphaga collected in Dominica. The "liphagane" meroterpenoid carbon skeleton of liphagal (1) is new. A biomimetic total synthesis has been used to confirm the constitution of liphagal (1) and support a proposed biogenesis.},
	keywords = {ANALOGS, PHOSPHOINOSITIDE 3-KINASE INHIBITORS},
	isbn = {1523-7060},
	url = {<Go to ISI>://000234657900037},
	author = {Marion, F. and Williams, D. E. and Patrick, B. O. and Hollander, I. and Mallon, R. and Kim, S. C. and Roll, D. M. and Feldberg, L. and Van Soest, R. and Andersen, R. J.}
}
@article {1125,
	title = {Carbohydrate-bearing 3-hydroxy-4-pyridinonato complexes of gallium(III) and indium(III)},
	journal = {Bioconjugate Chemistry},
	volume = {16},
	number = {6},
	year = {2005},
	note = {ISI Document Delivery No.: 985QSTimes Cited: 17Cited Reference Count: 38},
	month = {Nov-Dec},
	pages = {1597-1609},
	type = {Article},
	abstract = {Gallium and indium complexes with pendant carbohydrates have been prepared and examined for their potential as radiopharmaceuticals. Carbohydrate-bearing 3-hydroxy-4-pyridinone ligand precursors and their tris(ligand)gallium(III) and -indium(III) complexes were synthesized and characterized by mass spectrometry, elemental analysis, and H-1 and C-13 NMR spectroscopy, and in the case of one intermediate, by X-ray crystallography. With three equivalents of ligand, neutral complexes formed with the bidentate hydroxypyridinone moiety complexing the gallium(III) and indium(III) metal centers.},
	keywords = {aluminum, ANALOGS, CITRATE, GLUCOSE, INVIVO, SYSTEM, TC-99M},
	isbn = {1043-1802},
	url = {<Go to ISI>://000233393800036},
	author = {Green, D. E. and Ferreira, C. L. and Stick, R. V. and Patrick, B. O. and Adam,Michael J. and Orvig, Chris}
}
@article {1125,
	title = {Carbohydrate-bearing 3-hydroxy-4-pyridinonato complexes of gallium(III) and indium(III)},
	journal = {Bioconjugate Chemistry},
	volume = {16},
	number = {6},
	year = {2005},
	note = {ISI Document Delivery No.: 985QSTimes Cited: 17Cited Reference Count: 38},
	month = {Nov-Dec},
	pages = {1597-1609},
	type = {Article},
	abstract = {Gallium and indium complexes with pendant carbohydrates have been prepared and examined for their potential as radiopharmaceuticals. Carbohydrate-bearing 3-hydroxy-4-pyridinone ligand precursors and their tris(ligand)gallium(III) and -indium(III) complexes were synthesized and characterized by mass spectrometry, elemental analysis, and H-1 and C-13 NMR spectroscopy, and in the case of one intermediate, by X-ray crystallography. With three equivalents of ligand, neutral complexes formed with the bidentate hydroxypyridinone moiety complexing the gallium(III) and indium(III) metal centers.},
	keywords = {aluminum, ANALOGS, CITRATE, GLUCOSE, INVIVO, SYSTEM, TC-99M},
	isbn = {1043-1802},
	url = {<Go to ISI>://000233393800036},
	author = {Green, D. E. and Ferreira, C. L. and Stick, R. V. and Patrick, B. O. and Adam,Michael J. and Orvig, Chris}
}
@article {1195,
	title = {High yielding synthesis of 3a-hydroxypyrrolo[2,3-b]indoline dipeptide methyl esters: Synthons for expedient introduction of the hydroxypyrroloindoline moiety into larger peptide-based natural products and for the creation of tryptathionine bridges},
	journal = {Journal of Organic Chemistry},
	volume = {70},
	number = {21},
	year = {2005},
	note = {ISI Document Delivery No.: 971SRTimes Cited: 12Cited Reference Count: 33},
	month = {Oct},
	pages = {8424-8430},
	type = {Article},
	abstract = {This work describes a rapid and high yielding oxidation of 14 tryptophanylated amino acid methyl esters to the corresponding 3 alpha-hydroxypyrrolo[2,3-b]indoline (Hpi) amino acids with generally facile separation of syn-cis and anti-cis diastereomers. Structural X-ray diffraction data are presented for both diastereomers of Tr-Hpi-Gly-OMe, which allow for a putative assignment of the other 13 pairs of diastereomers reported herein, based on correlations with H-1 NMR chemical shifts. Selective and high yielding deprotection at either the N or C terminus is described, allowing the Hpi motif to be introduced efficiently into potential targets with minimal protecting group manipulation. Two tripeptides containing Hpi and cysteine were prepared and treated with acid in the Savige-Fontana reaction to produce a cyclic tryptathionine linkage, characteristic of both amatoxins and phallotoxins.},
	keywords = {ANALOGS, ASYMMETRIC EPOXIDATION METHOD, CONFIGURATION, CONFORMATION, CYCLIZATION, CYSTEINE SULFHYDRYL-GROUPS, DERIVATIVES, HIMASTATIN, OXYGENATION, TRYPTOPHAN},
	isbn = {0022-3263},
	url = {<Go to ISI>://000232405500022},
	author = {May, J. P. and Fournier, P. and Pellicelli, J. and Patrick, B. O. and Perrin,David M.}
}
@article {1291,
	title = {Plasticity of influenza haemagglutinin fusion peptides and their interaction with lipid bilayers},
	journal = {Biophysical Journal},
	volume = {88},
	number = {1},
	year = {2005},
	note = {ISI Document Delivery No.: 884MYTimes Cited: 36Cited Reference Count: 72},
	month = {Jan},
	pages = {25-36},
	type = {Article},
	abstract = {A detailed molecular dynamics study of the haemagglutinin fusion peptide (N-terminal 20 residues of the HA2 subunits) in a model bilayer has yielded useful information about the molecular interactions leading to insertion into the lipids. Simulations were performed on the native sequence, as well as a number of mutant sequences, which are either fusogenic or nonfusogenic. For the native sequence and fusogenic mutants, the N-terminal 11 residues of the fusion peptides are helical and insert with a tilt angle of similar to30degrees with respect to the membrane normal, in very good agreement with experimental data. The tilted insertion of the native sequence peptide leads to membrane bilayer thinning and the calculated order parameters show larger disorder of the alkyl chains. These results indicate that the lipid packing is perturbed by the fusion peptide and could be used to explain membrane fusion. For the nonfusogenic sequences investigated, it was found that most of them equilibrate parallel to the interface plane and do not adopt a tilted conformation. The presence of a charged residue at the beginning of the sequence (G1E mutant) resulted in a more difficult case, and the outcomes do not fall straightforwardly into the general picture. Sequence searches have revealed similarities of the fusion peptide of influenza haemagglutinin with peptide sequences such as segments of porin, amyloid ab peptide, and a peptide from the prion sequence. These results confirm that the sequence can adopt different folds in different environments. The plasticity and the conformational dependence on the local environment could be used to better understand the function of fusion peptides.},
	keywords = {ANALOGS, CONFORMATION, HEMAGGLUTININ, MEDIATED MEMBRANE-FUSION, MODEL MEMBRANES, MOLECULAR-DYNAMICS SIMULATION, MULTIPLE ALIGNMENT, RECEPTOR-BINDING, SEQUENCE, VIRAL FUSION, VIRUS},
	isbn = {0006-3495},
	url = {<Go to ISI>://000226090900006},
	author = {Vaccaro, L. and Cross, K. J. and Kleinjung, J. and Straus, S. K. and Thomas, D. J. and Wharton, S. A. and Skehel, J. J. and Fraternali, F.}
}
@article {1204,
	title = {Synthesis and characterization of dual function vanadyl, gallium and indium curcumin complexes for medicinal applications},
	journal = {Journal of Inorganic Biochemistry},
	volume = {99},
	number = {11},
	year = {2005},
	note = {ISI Document Delivery No.: 984RUTimes Cited: 22Cited Reference Count: 41},
	month = {Nov},
	pages = {2217-2225},
	type = {Article},
	abstract = {Novel bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione (curcumin) complexes with the formula, ML3, where M is Ga(III) or In(III), or of the formula, ML2 where M is [Vo](2+), have been synthesized and characterized by mass spectrometry, infrared and absorption spectroscopies, and elemental analysis. A new ligand, bis[4-acetyl-3-hydroxyphenyl]-1,6-heptadiene-3,5-dione (diacetylbisdemethoxycurcumin, DABC) was similarly characterized; an X-ray structure analysis was performed. Vanadyl complexes tested in an acute i.p. testing protocol in STZ-diabetic rats showed a lack of insulin enhancing potential. Vanadyl complexes were, however, more cytotoxic than were the ligands alone in standard MTT (3-[4,5-dimethylthiazole-2-yl]ate, -2.5-diphenyl-tetrazolium bromide) cytotoxicity testing, using mouse lymphoma cells. With the exception of DABC, that was not different from VO(DABC)(2), the complexes were not significantly different from one another, with IC50 values in the 5-10 mu M range. Gallium and indium curcumin complexes had IC50 values in the same 5-10 mu M range; whereas Ga(DAC)(3) and In(DAC)(3) (where DAC = diacetylcurcumin) were much less cytotoxiC (IC50 = 20-30 mu M). Antioxidant capacity was decreased in VO(DAC)(2), Ga(DAC)(3), and In(DAC)(3),, compared to vanadyl, gallium and indium curcumin, corroborating the importance of curcumin{\textquoteright}s free phenolic OH groups for scavenging oxidants, and correlated with reduced cytotoxic potential. (c) 2005 Elsevier Inc. All rights reserved.},
	keywords = {ANALOGS, antioxidant capacity, ANTIOXIDANT MECHANISM, ANTITUMOR ACTIVITY, BINDING, COORDINATION CHEMISTRY, curcumin, cytotoxicity, DERIVATIVES, diacetylcurcumin, gallium, GROUP, indium, INSULIN MIMICS, MANGANESE COMPLEXES, RADICAL SCAVENGING ABILITY, TOXICITY, VANADIUM},
	isbn = {0162-0134},
	url = {<Go to ISI>://000233322800012},
	author = {Mohammadi, K. and Thompson, K. H. and Patrick, B. O. and Storr, T. and Martins, C. and Polishchuk, E. and Yuen, V. G. and McNeill, J. H. and Orvig, Chris}
}
@article {1032,
	title = {Boneratamides A-C, new sesquiterpenoids isolated from the marine sponge Axinyssa aplysinoides},
	journal = {Journal of Natural Products},
	volume = {67},
	number = {10},
	year = {2004},
	note = {ISI Document Delivery No.: 865MRTimes Cited: 4Cited Reference Count: 14},
	month = {Oct},
	pages = {1752-1754},
	type = {Article},
	abstract = {Three new sesquiterpenoids, boneratamides A (1)-C (3), have been isolated as their methyl esters 4-6 from extracts of the marine sponge Axinyssa aplysinoides collected in Indonesia. The structures of methyl esters 4-6 were elucidated by analysis of spectroscopic data and confirmed by single-crystal X-ray diffraction analysis of 4.},
	keywords = {AGENT, ANALOGS, BINDING, HEMIASTERLIN, NATURAL-PRODUCTS, PACLITAXEL, TUBULIN},
	isbn = {0163-3864},
	url = {<Go to ISI>://000224707700025},
	author = {Williams, D. E. and Patrick, B. O. and Tahir, A. and Van Soest, R. and Roberge, M. and Andersen, R. J.}
}
@article {680,
	title = {Ceratamines A and B, antimitotic heterocyclic alkaloids isolated from the marine sponge Pseudoceratina sp collected in Papua New Guinea},
	journal = {Organic Letters},
	volume = {5},
	number = {24},
	year = {2003},
	note = {ISI Document Delivery No.: 746CHTimes Cited: 18Cited Reference Count: 10},
	month = {Nov},
	pages = {4591-4594},
	type = {Article},
	abstract = {Two novel antimitotic heterocyclic alkaloids, ceratamines A (1) and B (2), have been isolated from the marine sponge Pseudoceratina sp., collected in Papua New Guinea. The structures of 1 and 2 were elucidated by analysis of spectroscopic data.},
	keywords = {ANALOGS, HEMIASTERLIN},
	isbn = {1523-7060},
	url = {<Go to ISI>://000186728600016},
	author = {Manzo, E. and Van Soest, R. and Matainaho, L. and Roberge, M. and Andersen, R. J.}
}
@article {4661,
	title = {Cationic iron(III) complex with a hexadentate N-2,N {\textquoteright}(2),O-2-aminopyridylphenolate ligand},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {77},
	number = {12},
	year = {1999},
	note = {ISI Document Delivery No.: 262KYTimes Cited: 14Cited Reference Count: 34},
	month = {Dec},
	pages = {2033-2038},
	type = {Article},
	abstract = {{Iron(III) complexation with potentially hexadentate H(2)bbpen (N,N{\textquoteright}-bis(2-hydroxybenzyl)-N,N{\textquoteright}-bis(2-methylpyridyl)ethylenediamine) was studied. The resulting monocationic complex, [Fe(bbpen)](+) as its NO3- and PF6- salts, was characterized by infrared spectroscopy, mass spectrometry, elemental analyses, cyclic voltammetry, and X-ray crystallographic analysis. Crystals of [Fe(bbpen)]NO3. CH3OH are monoclinic, space group P2(1)/c},
	keywords = {ANALOGS, BINDING-SITE, CATIONIC, CRYSTAL-STRUCTURE, gallium, hexadentate, indium, iron( III), LACTOFERRIN, MODEL, OXO, phenolate, PROTEINS, pyridyl},
	isbn = {0008-4042},
	url = {<Go to ISI>://000084067500004},
	author = {Setyawati, I. A. and Rettig, S. J. and Orvig, Chris}
}
@article {7054,
	title = {STRUCTURAL STUDIES OF ORGANOBORON COMPOUNDS .44. 2,3-DIHYDRO-3-HYDROXY-2,2-TETRAMETHYLENE-4H-BENZOXAZIN-4-ONE AND ITS DIFLUOROBORON CHELATE, 2,2-DIFLUORO-4,4-TETRAMETHYLENE-1,3,5-TRIOXA-3A-AZONIA-2-BORATA-2,3,4,5- TETRAHYDRO-1H-CYCLOPENTA[A]NAPHTHALENE},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {69},
	number = {4},
	year = {1991},
	note = {ISI Document Delivery No.: FL979Times Cited: 4Cited Reference Count: 28},
	month = {Apr},
	pages = {673-680},
	type = {Article},
	abstract = {{The reaction of 2,3-dihydro-3-hydroxy-2,2-tetramethylene-4H-benzoxazin-4-one, 2, and diethyl ether-boron trifluoride yields the difluoroboron chelate 2,2-difluoro-4,4-tetramethylene-1,3,5-trioxa-3a-azonia-2-borata-2,3,4,5- tetrahydro-1H-cyclopenta[a]naphthalene, 6, in high yield. There are two crystal forms of 2: 2a, triclinic, P1BAR},
	keywords = {ADJACENT ACYL LIGANDS, ANALOGS, BORON COMPOUND, CARBON BOND FORMATION, COMPLEXES, COORDINATED MOLECULES, CRYSTAL, crystal structure, organoboron compound, RING},
	isbn = {0008-4042},
	url = {<Go to ISI>://A1991FL97900014},
	author = {Kliegel, W. and Tajerbashi, M. and Rettig, S. J. and Trotter, J.}
}
