@article {2435,
	title = {A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds},
	journal = {Nature Biotechnology},
	volume = {27},
	number = {4},
	year = {2009},
	note = {ISI Document Delivery No.: 430EOTimes Cited: 27Cited Reference Count: 60Ho, Cheuk Hei Magtanong, Leslie Barker, Sarah L. Gresham, David Nishimura, Shinichi Natarajan, Paramasivam Koh, Judice L. Y. Porter, Justin Gray, Christopher A. Andersen, Raymond J. Giaever, Guri Nislow, Corey Andrews, Brenda Botstein, David Graham, Todd R. Yoshida, Minoru Boone, Charles},
	month = {Apr},
	pages = {369-377},
	type = {Article},
	abstract = {We present a yeast chemical-genomics approach designed to identify genes that when mutated confer drug resistance, thereby providing insight about the modes of action of compounds. We developed a molecular barcoded yeast open reading frame (MoBY-ORF) library in which each gene, controlled by its native promoter and terminator, is cloned into a centromere-based vector along with two unique oligonucleotide barcodes. The MoBY-ORF resource has numerous genetic and chemical-genetic applications, but here we focus on cloning wild-type versions of mutant drug-resistance genes using a complementation strategy and on simultaneously assaying the fitness of all transformants with barcode microarrays. The complementation cloning was validated by mutation detection using whole-genome yeast tiling microarrays, which identified unique polymorphisms associated with a drug-resistant mutant. We used the MoBY-ORF library to identify the genetic basis of several drug-resistant mutants and in this analysis discovered a new class of sterol-binding compounds.},
	keywords = {1, 2, 3-BETA-D-GLUCAN SYNTHASE, CYCLOHEXIMIDE, DELETION MUTANTS, ELONGATION-FACTOR, GENE-DELETION, MAMMALIAN PROTEIN, ORDERED ARRAYS, OVEREXPRESSION STRAINS, resistance, SACCHAROMYCES-CEREVISIAE GENOME, SPONGE THEONELLA SP},
	isbn = {1087-0156},
	url = {<Go to ISI>://000264971800023},
	author = {Ho, C. H. and Magtanong, L. and Barker, S. L. and Gresham, D. and Nishimura, S. and Natarajan, P. and Koh, J. L. Y. and Porter, J. and Gray, C. A. and Andersen, R. J. and Giaever, G. and Nislow, C. and Andrews, B. and Botstein, D. and Graham, T. R. and Yoshida, M. and Boone, C.}
}
@article {3851,
	title = {Ferintoic acids A and B, new cyclic hexapeptides from the freshwater cyanobacterium Microcystis aeruginosa},
	journal = {Journal of Natural Products},
	volume = {59},
	number = {6},
	year = {1996},
	note = {ISI Document Delivery No.: UT658Times Cited: 23Cited Reference Count: 30},
	month = {Jun},
	pages = {570-575},
	type = {Article},
	abstract = {The cyclic hexapeptides ferintoic acids A (1) and B (2) have been isolated from cells of Microcystis aeruginosa harvested during a natural bloom of the toxic cyanobacterium. The structures of 1 and 2 were determined by a combination of spectroscopic analysis and chemical degradation.},
	keywords = {AMINO-ACIDS, BLUE-GREEN-ALGA, INHIBITOR, LR, PEPTIDE, PHASE, PROTEIN PHOSPHATASES, SPONGE THEONELLA SP, TOXIN},
	isbn = {0163-3864},
	url = {<Go to ISI>://A1996UT65800004},
	author = {Williams, D. E. and Craig, M. and Holmes, C. F. B. and Andersen, R. J.}
}
@article {2702,
	title = {NEW NATURAL-PRODUCTS FROM MARINE-INVERTEBRATES},
	journal = {Gazzetta Chimica Italiana},
	volume = {123},
	number = {6},
	year = {1993},
	note = {ISI Document Delivery No.: LL566Times Cited: 3Cited Reference Count: 457TH INTERNATIONAL SYMP ON MARINE NATURAL PRODUCTS ( VII MANAPRO )JUL 05-10, 1992CAPRI, ITALY},
	month = {Jun},
	pages = {293-299},
	type = {Proceedings Paper},
	abstract = {Extracts of marine invertebrates collected in British Columbia and Papua New Guinea have been screened for the presence of cytotoxic and enzyme modulatory metabolites. Chemical examination of several active extracts has resulted in the identification of a number of novel natural products. These include: contignasterol, 2, a steroid having a cis C/D ring junction; pseudaxinellin, 5, a cyclic heptapeptide; trididemnic acids A, 7, and B, 8, two aromatic alkaloids from a tunicate; the rubrolides A, 13, to H, 20, a family of highly halogenated tunicate metabolites; and motuporin, 22, a cyclic pentapeptide that is the first marine representative of the microcystin class of hepatotoxic and tumor-promoting cyclic peptides. Microcystin LR has been found in marine shellfish for the first time and it has been implicated as the cause of a severe liver disease that occurs in netpen reared salmon in British Columbia.},
	keywords = {METABOLITES, microcystin, OKADAIC ACID, PEPTIDE, POTENT, SPONGE THEONELLA SP, TUMOR PROMOTER},
	isbn = {0016-5603},
	url = {<Go to ISI>://A1993LL56600001},
	author = {Andersen, R. J. and Burgoyne, D. L. and Williams, D. E. and Kong, F. M. and De Silva, E. D. and Miao, S. C. and Allen, T. M. and Holmes, C. F. B. and Chen, D. and Kent, M.}
}
