@article {2118,
	title = {Unimolecular Micelles based on Hydrophobically Derivatized Hyperbranched Polyglycerols: Biodistribution Studies},
	journal = {Bioconjugate Chemistry},
	volume = {19},
	number = {11},
	year = {2008},
	note = {ISI Document Delivery No.: 373VOTimes Cited: 7Cited Reference Count: 31Kainthan, Rajesh Kumar Brooks, Donald E.},
	month = {Nov},
	pages = {2231-2238},
	type = {Article},
	abstract = {We recently reported the synthesis and testing of a new class of unimolecular micelles based on hyperbranched polyglycerols as second generation synthetic plasma expanders and as general drug delivery vehicles. A detailed biodistribution study of two derivatized hyperbranched polyglycerols of different molecular weights derivatized with hydrophobic groups and short poly(ethylene glycol) chains is reported in this article. In mice, these materials are nontoxic with circulation half-lives as high as 31 h, controllable by manipulating the molecular weight and the degree of PEG derivatization. Organ accumulation is low, presumably due to the "pegylation" effect. Thermal degradation and hydrolysis data suggest that these polymers are highly stable with a long shelf life, a major advantage for a pharmaceutical product. Degradation under acidic conditions has been observed for these polymers.},
	keywords = {ALBUMIN, BIOLOGICAL EVALUATION, DENDRIMERS, IMMUNOGENICITY, IN-VIVO, LIPOSOMES, MOLECULAR-WEIGHT, POLYETHYLENE-GLYCOL DEGRADATION, POLYMERS, STARCH},
	isbn = {1043-1802},
	url = {<Go to ISI>://000261001800018},
	author = {Kainthan, R. K. and Brooks, D. E.}
}
@article {4570,
	title = {Poly(styrene) latex carrying cerium(IV)-initiated terminally attached cleavable chains: Analysis of grafted chains and model of the surface layer},
	journal = {Macromolecules},
	volume = {32},
	number = {3},
	year = {1999},
	note = {ISI Document Delivery No.: 166HKTimes Cited: 14Cited Reference Count: 40},
	month = {Feb},
	pages = {565-573},
	type = {Article},
	abstract = {Ce(IV)-initiated grafting of N(2-methoxyethyl-acrylamide) (MEA) to a shell of poly(styrene-co-2-hydroxyethyl acrylate) on polystyrene latex has been performed and the molecular weight distribution of the graft determined by size exclusion chromatography (SEC) on grafted chains cleaved from the surface. Cationic poly(styrene) beads were covered with a shell containing poly(styrene-co-2-hydroxyethyl acrylate) utilizing an azo initiator. The density of the surface hydroxyl groups was assessed by saponification of the ester bonds followed by conductometric titration of the resulting carboxylic residues. Ce(TV) redox initiation of MEA from the surface hydroxyl groups produced chains terminally attached to the latex surface. MEA consumption kinetics were monitored by HPLC of the supernatant on a reverse phase column. Competing solution polymerization of MEA occurred, probably due to leakage of shell copolymer from the beads. The terminally attached chains were characterized by quantitative SEC following cleavage from the surface by saponification, allowing a model of the tethered surface to be developed.},
	keywords = {ACRYLATE, CARBOXY METHYL CELLULOSE, CHROMATOGRAPHY, COPOLYMERIZATION, METHACRYLATE, POLYMERIZATION, REDOX SYSTEM, STARCH},
	isbn = {0024-9297},
	url = {<Go to ISI>://000078570000005},
	author = {Hritcu, D. and Muller, W. and Brooks, D. E.}
}
