@article {2542,
	title = {Paclitaxel incorporated in hydrophobically derivatized hyperbranched polyglycerols for intravesical bladder cancer therapy},
	journal = {Bju International},
	volume = {103},
	number = {7},
	year = {2009},
	note = {ISI Document Delivery No.: 417GSTimes Cited: 6Cited Reference Count: 37Mugabe, Clement Hadaschik, Boris A. Kainthan, Rajesh K. Brooks, Donald E. So, Alan I. Gleave, Martin E. Burt, Helen M.},
	month = {Apr},
	pages = {978-986},
	type = {Article},
	abstract = {To develop paclitaxel incorporated into unimolecular micelles based on hydrophobically derivatized hyperbranched polyglycerols (dHPGs) for use as mucoadhesive intravesical agents against non-muscle-invasive bladder cancer. Two different types of dHPGs (HPG- C10-polyethylene glycol (PEG) and polyethyleneimine (PEI)-C18-HPG) were synthesized and paclitaxel was loaded into these using a solvent evaporation method. After physicochemical characterization of the resulting nanoparticles, four human bladder cancer cell lines were incubated with various concentrations of paclitaxel incorporated in dHPGs and the results were compared with those of paclitaxel formulated in Cremophor-EL (Taxol (R), Bristol-Myers-Squibb). In vivo, nude mice with orthotopic KU7-luc tumours were intravesically instilled with phosphate buffered saline, Taxol, or paclitaxel/HPG-C10-PEG. dHPGs are mucoadhesive nanoparticles with hydrodynamic radii of < 10 nm and incorporation of paclitaxel did not affect their size. The release profiles of paclitaxel from dHPGs were characterized by a rapid-release phase followed by a slower sustained-release phase. While the PEI-C18-HPG formulation released only approximate to 40\% of the initially incorporated paclitaxel, up to 80\% was released from HPG-C10-PEG. Moreover, only paclitaxel/HPG-C10-PEG was stable in acidic urine. In vitro, all paclitaxel formulations potently decreased bladder cancer proliferation although paclitaxel/HPG-C10-PEG was slightly less cytotoxic than standard Taxol. By contrast, in vivo, the mucoadhesive HPG-C10-PEG formulation of paclitaxel was significantly more effective in reducing orthotopic tumour growth than Taxol and was well tolerated. Intravesical administration of mucoadhesive nanoparticulate formulations of paclitaxel might be a promising approach for instillation therapy of patients with non-muscle-invasive bladder cancer.},
	keywords = {ARCHITECTURES, bladder cancer, chemotherapy, DESIGN, DRUG-DELIVERY, hyperbranched polyglycerols, intravesical therapy, MANAGEMENT, MICROSPHERES, MUCOADHESION, orthotopic mouse model, PACLITAXEL, pharmacokinetics, POLYMERS, unimolecular micelles},
	isbn = {1464-4096},
	url = {<Go to ISI>://000264065100022},
	author = {Mugabe, C. and Hadaschik, B. A. and Kainthan, R. K. and Brooks, D. E. and So, A. I. and Gleave, M. E. and Burt, H. M.}
}
@article {2033,
	title = {Engineered elastomeric proteins with dual elasticity can be controlled by a molecular regulator},
	journal = {Nature Nanotechnology},
	volume = {3},
	number = {8},
	year = {2008},
	note = {ISI Document Delivery No.: 335WZTimes Cited: 12Cited Reference Count: 29Cao, Yi Li, Hongbin},
	month = {Aug},
	pages = {512-516},
	type = {Article},
	abstract = {Elastomeric proteins are molecular springs that confer excellent mechanical properties(1-5) to many biological tissues and biomaterials. Depending on the role performed by the tissue or biomaterial, elastomeric proteins can behave as molecular springs(1,2,6,7) or shock absorbers(3-5,8-10). Here we combine single-molecule atomic force microscopy and protein engineering techniques to create elastomeric proteins that can switch between two distinct types of mechanical behaviour in response to the binding of a molecular regulator. The proteins are mechanically labile by design and behave as entropic springs with an elasticity that is governed by their configurational entropy. However, when a molecular regulator binds to the protein, it switches into a mechanically stable state and can act as a shock absorber. These engineered proteins effectively mimic and combine the two extreme forms of elastic behaviour found in natural elastomeric proteins, and thus represent a new type of smart nanomaterial that will find potential applications in nanomechanics and material sciences.},
	keywords = {BINDING, BIOLOGICAL ROLES, DESIGN, DOMAINS, FORCE-SPECTROSCOPY, MECHANICAL-PROPERTIES, STABILITY, TITINS, TOPOLOGY},
	isbn = {1748-3387},
	url = {<Go to ISI>://000258325800018},
	author = {Cao, Y. and Li, H. B.}
}
@article {2034,
	title = {Single molecule force spectroscopy reveals engineered metal chelation is a general approach to enhance mechanical stability of proteins},
	journal = {Proceedings of the National Academy of Sciences of the United States of America},
	volume = {105},
	number = {32},
	year = {2008},
	note = {ISI Document Delivery No.: 339EKTimes Cited: 16Cited Reference Count: 44Cao, Yi Yoo, Teri Li, Hongbin},
	month = {Aug},
	pages = {11152-11157},
	type = {Article},
	abstract = {Significant mechanical stability is an essential feature shared by many elastomeric proteins, which function as molecular springs in a wide variety of biological machinery and biomaterials of superb mechanical properties. Despite the progress in understanding molecular determinants of mechanical stability, it remains challenging to rationally enhance the mechanical stability of proteins. Using single molecule force spectroscopy and protein engineering techniques, we demonstrate that engineered bi-histidine metal chelation can enhance the mechanical stability of proteins significantly and reversibly. Based on simple thermodynamic cycle analysis, we engineered a bi-histidine metal chelation site into various locations of the small protein, GB1, to achieve preferential stabilization of the native state over the mechanical unfolding transition state of GB1 through the binding of metal ions. Our results demonstrate that the metal chelation can enhance the mechanical stability of GB1 by as much as 100 pN. Since bi-histidine metal chelation sites can be easily implemented, engineered metal chelation provides a general methodology to enhance the mechanical stability of a wide variety of proteins. This general approach in protein mechanics will enable the rational tuning of the mechanical stability of proteins. It will not only open new avenues toward engineering proteins of tailored nanomechanical properties, but also provide new approaches to systematically map the mechanical unfolding pathway of proteins.},
	keywords = {BINDING SITES, charge, DESIGN, DOMAINS, ELASTICITY, engineering, EXTRACELLULAR-MATRIX PROTEIN, mechanical unfolding, PROTEIN, protein mechanics, rational design, SIMULATIONS, STABILIZATION, STRENGTH, THERMOSTABILITY, TITIN},
	isbn = {0027-8424},
	url = {<Go to ISI>://000258560700024},
	author = {Cao, Y. and Yoo, T. and Li, H. B.}
}
@article {2287,
	title = {Toward [F-18]-labeled aryltrifluoroborate radiotracers: In vivo positron emission tomography imaging of stable aryltrifluoroborate clearance in mice},
	journal = {Journal of the American Chemical Society},
	volume = {130},
	number = {36},
	year = {2008},
	note = {ISI Document Delivery No.: 344TPTimes Cited: 15Cited Reference Count: 35Ting, Richard Harwig, Curtis auf dem Keller, Ulrich McCormick, Siobhan Austin, Pamela Overall, Christopher M. Adam, Michael J. Ruth, Thomas J. Perrin, David M.},
	month = {Sep},
	pages = {12045-12055},
	type = {Article},
	abstract = {The use of a boronic ester as a captor of aqueous [F-18]-fluoride has been previously suggested as a means of labeling biomolecules in one step for positron emission tomography (PET) imaging. For this approach to be seriously considered, the [F-18]-labeled trifluoroborate should be humorally stable such that it neither leaches free [F-18]-fluoride to the bone nor accumulates therein. Herein, we have synthesized a biotinylated boronic ester that is converted to the corresponding trifluoroborate salt in the presence of aqueous [F-18]-fluoride. In keeping with its in vitro aqueous kinetic stability at pH 7.5, the trifluoroborate appears to clear in vivo quite rapidly to the bladder as the stable trifluoroborate salt with no detectable leaching of free [F-18]-fluoride to the bone. When this labeled biotin is preincubated with avidin, the pharmacokinetic clearance of the resulting complex is visibly altered. This work validates initial claims that boronic esters are potentially useful as readily labeled precursors to [F-18]-PET reagents.},
	keywords = {apoptosis, BIODISTRIBUTION, CANCER, DESIGN, F-18, MICROPET, NO-CARRIER, PEPTIDES, PET, STABILITY},
	isbn = {0002-7863},
	url = {<Go to ISI>://000258950500044},
	author = {Ting, R. and Harwig, C. and auf dem Keller, U. and McCormick, S. and Austin, P. and Overall, C. M. and Adam,Michael J. and Ruth, T. J. and Perrin,David M.}
}
@article {2287,
	title = {Toward [F-18]-labeled aryltrifluoroborate radiotracers: In vivo positron emission tomography imaging of stable aryltrifluoroborate clearance in mice},
	journal = {Journal of the American Chemical Society},
	volume = {130},
	number = {36},
	year = {2008},
	note = {ISI Document Delivery No.: 344TPTimes Cited: 15Cited Reference Count: 35Ting, Richard Harwig, Curtis auf dem Keller, Ulrich McCormick, Siobhan Austin, Pamela Overall, Christopher M. Adam, Michael J. Ruth, Thomas J. Perrin, David M.},
	month = {Sep},
	pages = {12045-12055},
	type = {Article},
	abstract = {The use of a boronic ester as a captor of aqueous [F-18]-fluoride has been previously suggested as a means of labeling biomolecules in one step for positron emission tomography (PET) imaging. For this approach to be seriously considered, the [F-18]-labeled trifluoroborate should be humorally stable such that it neither leaches free [F-18]-fluoride to the bone nor accumulates therein. Herein, we have synthesized a biotinylated boronic ester that is converted to the corresponding trifluoroborate salt in the presence of aqueous [F-18]-fluoride. In keeping with its in vitro aqueous kinetic stability at pH 7.5, the trifluoroborate appears to clear in vivo quite rapidly to the bladder as the stable trifluoroborate salt with no detectable leaching of free [F-18]-fluoride to the bone. When this labeled biotin is preincubated with avidin, the pharmacokinetic clearance of the resulting complex is visibly altered. This work validates initial claims that boronic esters are potentially useful as readily labeled precursors to [F-18]-PET reagents.},
	keywords = {apoptosis, BIODISTRIBUTION, CANCER, DESIGN, F-18, MICROPET, NO-CARRIER, PEPTIDES, PET, STABILITY},
	isbn = {0002-7863},
	url = {<Go to ISI>://000258950500044},
	author = {Ting, R. and Harwig, C. and auf dem Keller, U. and McCormick, S. and Austin, P. and Overall, C. M. and Adam,Michael J. and Ruth, T. J. and Perrin,David M.}
}
@article {2180,
	title = {Twenty years of interface development for capillary electrophoresis-electrospray ionization-mass spectrometry},
	journal = {Analytica Chimica Acta},
	volume = {627},
	number = {1},
	year = {2008},
	note = {ISI Document Delivery No.: 358IYTimes Cited: 22Cited Reference Count: 76Maxwell, E. Jane Chen, David D. Y.Sp. Iss. SI},
	month = {Oct},
	pages = {25-33},
	type = {Review},
	abstract = {Capillary electrophoresis-electrospray ionization-mass spectrometry has the potential to become a preferred tool for the analysis of biological mixtures and other complex samples. The development of improved interfaces in the past twenty years has been critical in demonstrating the feasibility of this technique. However, a compromise still exists between interfaces that give optimal performance and those that are practical for commercial applications. The first section of this review focuses on the technological advances in CE-ESI-MS as they relate to the key interface features for both sheath-flow and sheathless systems: delivery of the sheath liquid, shaping of the emitter tip, formation of electrical contact, and practicality in terms of ease of use and lifetime. In the second section, we review the fundamental processes that affect interface performance. Because of the complex natures of both capillary electrophoresis and electrospray ionization, flow rate, arrangement of the electrical circuit, electrochemistry, tip geometry and location of electrical contact must all be carefully managed in the design of a successful interface. (C) 2008 Elsevier B.V. All rights reserved.},
	keywords = {BEVELED EDGE, capillary electrophoresis, DESIGN, electrospray ionization, EMITTERS, FLOW NANOSPRAY, FUSED-SILICA CAPILLARY, interface development, JUNCTION INTERFACE, LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY, MASS SPECTROMETRY, MICRO-ELECTROSPRAY, SHEATHLESS CAPILLARY, ZONE-ELECTROPHORESIS},
	isbn = {0003-2670},
	url = {<Go to ISI>://000259911600003},
	author = {Maxwell, E. J. and Chen, D. D. Y.}
}
@article {1545,
	title = {Characterization of de novo four-helix bundles by molecular dynamics simulations},
	journal = {Proteins-Structure Function and Bioinformatics},
	volume = {64},
	number = {3},
	year = {2006},
	note = {ISI Document Delivery No.: 064QITimes Cited: 5Cited Reference Count: 34Scott, Walter R. P. Seo, Emily Huttunen, Heidi Wallhorn, Diana Sherman, John C. Straus, Suzana K.},
	month = {Aug},
	pages = {719-729},
	type = {Article},
	abstract = {We have investigated the structure and dynamics of three cavitand-based four-helix bundles (caviteins) by computer simulation. In these systems, designed de novo, each of the four helices contain the identical basis sequence EELLKKLEELLKKG (N1). Each cavitein consists of a rigid macrocycle (cavitand) with four aryl linkages, to each of which is connected an NI peptide by means of a linker peptide. The three caviteins studied here differ only in the linker peptide, which consist of one, two, or three glycine residues. Previous experimental work has shown that these systems exhibit very different behavior in terms of stability and oligomerization states despite the small differences in the linker peptide. Given that to date no three-dimensional structure is available for these caviteins, we have undertaken a series of molecular dynamics (MD) simulations in explicit water to try to rationalize the large differences in the experimentally observed behavior of these systems. Our results provide insight, for the first time, into why and how the cavitein with a single glycine linker forms dimers. In addition, our results indicate why although the two- and three-glycine-linked caviteins have similar stabilities, they have different native-like characteristics: the cavitein with three glycines can form a supercoiled helix, whereas the one with two glycines cannot. These findings may provide a useful guide in the rational de novo design of novel proteins with finely tunable structures and functions in the future.},
	keywords = {caviteins, de novo four-helix bundle, DESIGN, DOMAIN, HELICAL BUNDLES, molecular dynamics simulations, PEPTIDE, PROTEIN DESIGN, PROTEINS, STATE, SYSTEM, TASP, template-assembled synthetic protein},
	isbn = {0887-3585},
	url = {<Go to ISI>://000239103800014},
	author = {Scott, W. R. P. and Seo, E. and Huttunen, H. and Wallhorn, D. and Sherman, J. C. and Straus, S. K.}
}
@article {1630,
	title = {Plastic separation planning for end-of-life electronics},
	journal = {Ieee Transactions on Electronics Packaging Manufacturing},
	volume = {29},
	number = {2},
	year = {2006},
	note = {ISI Document Delivery No.: 046PLTimes Cited: 3Cited Reference Count: 34},
	month = {Apr},
	pages = {110-118},
	type = {Article},
	abstract = {Important challenges remain for sustainable design, manufacture, use, and recycling of electronics including materials selection and disassembly time. This paper examines the value relationship between the quantity of plastics separated and the time required for disassembly and segregation. Labor,costs for disassembly can constitute a large portion of the total acquisition cost for a recycled material. We report work measurement studies conducted on the disassembly of 21 computers, 22 printers, and 32 monitors manufactured by 27 producers in the years from 1984 to 2001. Results include the weight per total separation time for each plastic part. Each recovered part is identified according to polymer resin using laser Raman spectroscopy by chemometric reference to a library of standards. We extrapolate time as well as the product input required to accumulate various specific types of plastic. We develop disassembly policies and show that they are effective for a variety of computer, printer, or monitor models, which is typical of the random product streams that arrive at electronics recycling facilities. The results demonstrate how new laser identification tech- nology and work measurement can be used for plastics separation planning.},
	keywords = {DESIGN, disassembly, electronics recycling, measurement, plastics, Raman spectroscopy, work},
	isbn = {1521-334X},
	url = {<Go to ISI>://000237823400006},
	author = {Williams, J. A. S. and Grant, E. R. and Rios, P. and Blyler, L. and Tieman, L. and Twining, L. and Bonawi-Tan, W. and Madden, M. and Guthrie, N. R. M.}
}
@article {1526,
	title = {Viable plastics recycling from end-of-life electronics},
	journal = {Ieee Transactions on Electronics Packaging Manufacturing},
	volume = {29},
	number = {1},
	year = {2006},
	note = {ISI Document Delivery No.: 010ALTimes Cited: 3Cited Reference Count: 62},
	month = {Jan},
	pages = {25-31},
	type = {Article},
	abstract = {Millions of end-of-life (EOL) electronic products represent more than one million tons of engineering thermoplastics. The economically and environmentally sound recovery of engineering thermoplastics from EOL electronics is a challenge to the sustainability of electronics manufacturing. In this paper, we review the technologies to separate and identify pure post-consumer plastics from EOL electronics, which are followed by the comparison of electronic plastics recycling processes and the network models for plastics recycling processes. We also review successful plastics recycling practices for electronics. In addition, further research directions for recycling plastics from EOL electronics are discussed.},
	keywords = {DECISION-MAKING, DESIGN, disassembly, end-of-life (EOL) electronics, HIGH-IMPACT POLYSTYRENE, IDENTIFICATION, METHODOLOGY, MODEL, OPTIMIZATION, plastics, PRODUCT, RECOVERY, recycling, SELECTIVE FLOTATION SEPARATION, SEPARATION},
	isbn = {1521-334X},
	url = {<Go to ISI>://000235155100004},
	author = {Qu, X. L. and Williams, J. A. S. and Grant, E. R.}
}
@article {982,
	title = {Protonated dipyrromethenes and tetrahalozinc anions as synthons in the solid state},
	journal = {Crystal Growth \& Design},
	volume = {4},
	number = {4},
	year = {2004},
	note = {ISI Document Delivery No.: 836KGTimes Cited: 15Cited Reference Count: 17},
	month = {Jul-Aug},
	pages = {659-661},
	type = {Editorial Material},
	abstract = {(HL)(2)ZnBr4 and (HL)(2)ZnCl4 were prepared by the addition of HBr or HCl into a CH3CN solution of Zn(II)L-2, and their structures were determined by X-ray diffraction analysis. The X-ray crystallographic data show super structures that have hydrogen bonds between the tetrahalozinc anions ([ZnX4](2-)) and the protonated dipyrromethene cations.},
	keywords = {CHEMISTRY, DESIGN, LIGANDS},
	isbn = {1528-7483},
	url = {<Go to ISI>://000222553800005},
	author = {Shin, J. Y. and Dolphin, D. and Patrick, B. O.}
}
@article {687,
	title = {A quantitative study of continuous flow-counterbalanced capillary electrophoresis for sample purification},
	journal = {Electrophoresis},
	volume = {24},
	number = {17},
	year = {2003},
	note = {ISI Document Delivery No.: 723ZZTimes Cited: 10Cited Reference Count: 25},
	month = {Sep},
	pages = {2887-2895},
	type = {Article},
	abstract = {A systematic evaluation of continuous flow-counterbalanced capillary electrophoresis for microscale preparative applications is presented. The success of the technique was found to depend on the specific nature of the analyte and background electrolyte and was most heavily influenced by factors such as solution conductivity and rate of buffer depletion. The performance of the technique for the system studied was ultimately limited by contamination arising from changes in analyte mobilities during extended run times. Marked improvements in both purification rate and yield were observed using the zwitterionic buffer 2-(N-cyclohexylamino)ethanesulfonic acid when compared to similar runs carried out using a borate background electrolyte. A quantitative evaluation of the technique was performed for the analytes studied and the performance of the technique has been compared to fraction collection methods. The highest recovery achieved was 5.2\% of the fastest migrating component present in the original sample with a resolution of 9 to the adjacent peak and required 100 min under optimized conditions. Recovery could be further increased to 9.0\% in 120 min for the same analyte using pressure-ramped flow-counterbalanced capillary electrophoresis.},
	keywords = {amino acid, BUFFER, DESIGN, flow-counterbalanced capillary electrophoresis, FRACTION COLLECTOR, LASER-INDUCED FLUORESCENCE, MASS-SPECTROMETRY, MEMBRANE, MICELLAR ELECTROKINETIC CHROMATOGRAPHY, PLASMA, PURIFICATION, SAMPLE, SEPARATION, tetramethylrhodamine isothiocyanate, ZONE-ELECTROPHORESIS, zwitterionic buffer},
	isbn = {0173-0835},
	url = {<Go to ISI>://000185462800002},
	author = {McLaren, D. G. and Chen, D. D. Y.}
}
@article {342,
	title = {A comparison of three- and four-helix bundle TASP molecules},
	journal = {Journal of Peptide Science},
	volume = {8},
	number = {6},
	year = {2002},
	note = {ISI Document Delivery No.: 563ZTTimes Cited: 14Cited Reference Count: 19},
	month = {Jun},
	pages = {275-282},
	type = {Article},
	abstract = {We have designed, synthesized and characterized three- and four-helix bundle template-assembled synthetic proteins (TASPs). The TASPs were synthesized using disulphide bonds between the peptides and either the cyclotribenzylene (CTB) template, or the cavitand (BOWL) template, to form the three- and four helix bundles, respectively. The TASPs were constructed using peptides that were linked via their N-termini (peptide CGGGEELLKKXEELLKKG, where X = L, I, Nle or V), or via their C-termini (peptide GEELLKKLEELLKKGGGC). Each TASP was assayed for its structure, stability, {\textquoteright}native-like{\textquoteright} characteristics and whether it was a monomer in solution. All TASPs were found to be highly helical, and highly resistant to chemical denaturation using guanidine hydrochloride (GnHCl). Analysis of the GnHCl-induced unfolding curves of the different TASPs demonstrated stability differences based on the number of helices in the bundle, the end of the helix that was attached to the template, and the identity of the core amino acid. The TASPs all had molten-globule structure, which is (generally) consistent with a degenerate sequence in the core. The four-helix bundle TASPs appeared to be monomers in solution, whereas there is some evidence that the three-helix bundle TASPs are weakly self associating. Copyright. (C) 2002 European Peptide Society and John Wiley Sons, Ltd.},
	keywords = {4-HELIX BUNDLES, DESIGN, four-helix bundle, PROTEIN, STABILITY, TASP, template assembled synthetic protein, three-helix bundle},
	isbn = {1075-2617},
	url = {<Go to ISI>://000176289000005},
	author = {Causton, A. S. and Sherman, J. C.}
}
@article {4638,
	title = {Porphyrins incorporating heterocyclic N-oxides: (oxidopyridyl)porphyrins, porphyrin-N-oxides, and a tirapazamine-porphyrin conjugate},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {77},
	number = {2},
	year = {1999},
	note = {ISI Document Delivery No.: 188AZTimes Cited: 9Cited Reference Count: 41},
	month = {Feb},
	pages = {182-198},
	type = {Article},
	abstract = {{Porphyrins containing one to four 3-pyridyl groups as meso-substituents were synthesized via a mixed aldehyde condensation, and then "N-oxidized" with m-chloroperbenzoic acid to produce five novel (oxidopyridyl) porphyrins and seven porphyrin-N-oxides which were characterized by analysis and spectroscopic methods, especially NMR; an X-ray crystal structure of 5-(1-oxido-4-pyridyl)-10, 15,20-triphenylporphyrin was also obtained. Crystals of (oxidopyridyl)triphenylporphyrin are tetragonal},
	keywords = {(oxidopyridyl)porphyrins, ANTICANCER, BIOREDUCTIVE DRUGS, DESIGN, DRUGS, FUNCTIONAL-GROUPS, NICKEL(II), PHENYL, PHOTODYNAMIC THERAPY, porphyrin-N-oxides, tirapazamine},
	isbn = {0008-4042},
	url = {<Go to ISI>://000079823200003},
	author = {Posakony, J. J. and Pratt, R. C. and Rettig, S. J. and James, Brian R. and Skov, K. A.}
}
@article {4336,
	title = {Tightening the hydrophobic belt: Effects of backbone and donor group variation on podand ligand complexes of the lanthanides},
	journal = {Inorganic Chemistry},
	volume = {37},
	number = {7},
	year = {1998},
	note = {ISI Document Delivery No.: ZG944Times Cited: 44Cited Reference Count: 53},
	month = {Apr},
	pages = {1637-1647},
	type = {Article},
	abstract = {{The N4O3 tripodal aminomethylene phosphinato ligand tris(4-phenylphosphinato-3-methyl-3-azabutyl)amine (H-3-ppma) forms mono- and bis(ligand) complexes with lanthanide(III) metal ions Ln when Ln = Sm-Lu. The formation constants of the Lu (log beta(1) = 1.79, log beta(2) = 4.40) and the Yb (log beta(1) = 2.25, log beta(2) = 4.42) complexes were determined at pH = 1.5 using an unusual P-31 NMR spectroscopic method. The molecular structure of the lutetium complex [Lu(H(3)ppma)(2)](NO3)(3) . 3H(2)O (C60H96LuN11O24P6) was solved by X-ray methods; it crystallizes in the trigonal space group R(3) over barc$, with a = 19.060(1) Angstrom},
	keywords = {AMINE PHENOL LIGANDS, BIOLOGICAL-SYSTEMS, CHEMISTRY, COORDINATION, DESIGN, HEPTADENTATE LIGANDS, METAL-IONS, NMR SHIFTS, NUCLEAR MAGNETIC-RESONANCE, STABILITY},
	isbn = {0020-1669},
	url = {<Go to ISI>://000073055700034},
	author = {Lowe, M. P. and Caravan, P. and Rettig, S. J. and Orvig, Chris}
}
@article {3925,
	title = {Selectivity among, and aggregation of, lanthanide ions},
	journal = {Journal of Alloys and Compounds},
	volume = {249},
	number = {1-2},
	year = {1997},
	note = {ISI Document Delivery No.: XC092Times Cited: 4Cited Reference Count: 1421st Rare Earth Research ConferenceJUL 07-12, 1996DULUTH, MNRare Earth Res Conf Inc, Univ Minnesota, USR Optonix Inc, Amer Chem Soc, Petr Res Fund, Arris Int Corp, Baotou Steel \& Rare Earth Co, US},
	month = {Mar},
	pages = {49-51},
	type = {Proceedings Paper},
	abstract = {Ligands that show selectivity towards, and aggregation of, lanthanides are of intrinsic interest in coordination chemistry. We have shown that Schiff base and amine phenolate ligands exhibit a variety of coordination modes in lanthanide(III) complexes, and that tren-(tris((2-amino)ethyl)amine)-based amine phenolates show selectivity towards later lanthanide(III) ions. By altering the nature of the amine phenolate ligand backbone the coordination mode of the ligand in solution can be easily controlled. Selectivity among lanthanide(III) ions can be controlled by substitution of the parent ligand donor atoms (phenolate oxygen) with donor atoms of a different type (e.g. phosphinate oxygen). By derivatizing the ligand to include more donor atoms and by stiffening the backbone, it is possible to control the aggregation of lanthanide(III) ions (enabling the formation of dimeric lanthanide complexes).},
	keywords = {aggregation of lanthanide ions, AMINE PHENOL LIGANDS, COMPLEXES, DESIGN, HEPTADENTATE LIGANDS, METAL-IONS, selectivity among lanthanide ions},
	isbn = {0925-8388},
	url = {<Go to ISI>://A1997XC09200010},
	author = {Caravan, P. and Lowe, M. P. and Read, P. W. and Rettig, S. J. and Yang, L. W. and Orvig, Chris}
}
@article {3342,
	title = {EFFICIENT COUPLING OF AMINO-ACID DERIVATIVES TO RIGID ORGANIC SCAFFOLDS - MODEL SYNTHESES FOR DE-NOVO PROTEINS},
	journal = {Tetrahedron},
	volume = {51},
	number = {32},
	year = {1995},
	note = {ISI Document Delivery No.: RM784Times Cited: 34Cited Reference Count: 42},
	month = {Aug},
	pages = {8719-8732},
	type = {Article},
	abstract = {We describe the coupling of amino acid derivatives to four different rigid organic macrocycles. The couplings were achieved in high yields, which augurs well for the coupling of polypeptides to the rigid macrocycles to create a new family of de novo proteins. We discuss the structure of the model compounds based on the hydrogen bonding patterns that are evident from their NMR and IR spectra.},
	keywords = {BUNDLE PROTEIN, DESIGN, PEPTIDE, TASP},
	isbn = {0040-4020},
	url = {<Go to ISI>://A1995RM78400004},
	author = {Gibb, B. C. and Mezo, A. R. and Causton, A. S. and Fraser, J. R. and Tsai, F. C. S. and Sherman, J. C.}
}
@article {3557,
	title = {HEXADENTATE N4O2 AMINE PHENOL COMPLEXES OF GALLIUM AND INDIUM},
	journal = {Inorganic Chemistry},
	volume = {34},
	number = {1},
	year = {1995},
	note = {ISI Document Delivery No.: QC360Times Cited: 46Cited Reference Count: 39},
	month = {Jan},
	pages = {93-101},
	type = {Article},
	abstract = {{Several linear N4O2 amine phenols based on triethylenetetramine (trien) were prepared and characterized by spectroscopic techniques (H(2)bad = 1,10-bis(2-hydroxybenzyl)-1,4,7,10-tetraazadecane; H(2)Clbad = 1,10-bis(2-hydroxy-5-chlorobenzyl)-1,4,7,10-tetraazadecane; H(2)Brbad = 1,10-bis(2-hydroxy-5-bromobenzyl)-1,4,7,10-tetraazadecane). These amine phenols were prepared by the in situ reduction of the corresponding Schiff bases, which were in turn derived from condensation reactions of trien with the appropriately substituted salicylaldehyde. Characterization of the amine phenols revealed two hydroxybenzyl groups connected to the trien backbone via the terminal primary amine nitrogen atoms. There are six potential sites for coordination to a metal ion: four amine nitrogens and two phenolate oxygens. Acetone adducts, prepared by refluxing the amine phenols in acetone, contained two imidazolidine rings, each of which was formed by the reaction of acetone with one inner and one terminal amine nitrogen. Monocationic metal complexes were obtained from the reactions of Ga3+ and In3+ with the N4O2 amine phenols in the presence of 2 equiv of base (acetate). The molecular structure of [Ga(Brbad)]-ClO4.(CH3)(2)SO (C22H32Br2ClGaN4O7S},
	keywords = {aluminum, CHEMISTRY, COORDINATION, CRYSTAL, DESIGN, Iron(III), METAL-IONS, SCHIFF-BASE LIGANDS},
	isbn = {0020-1669},
	url = {<Go to ISI>://A1995QC36000018},
	author = {Wong, E. and Liu, S. and Lugger, T. and Hahn, F. E. and Orvig, Chris}
}
@article {3343,
	title = {PROTOTYPE FOR A NEW FAMILY OF DE-NOVO PROTEINS},
	journal = {Tetrahedron Letters},
	volume = {36},
	number = {42},
	year = {1995},
	note = {ISI Document Delivery No.: RZ295Times Cited: 24Cited Reference Count: 30},
	month = {Oct},
	pages = {7587-7590},
	type = {Article},
	abstract = {We report the design, synthesis, and preliminary structural analysis of a four-helix bundle affixed to a rigid organic macrocycle.},
	keywords = {ASSEMBLED SYNTHETIC PROTEINS, CAVITANDS, CHANNEL, DESIGN, HOST GUEST COMPLEXATION, MOLECULAR, PEPTIDE, TASP, TOPOLOGY, VESSELS},
	isbn = {0040-4039},
	url = {<Go to ISI>://A1995RZ29500004},
	author = {Gibb, B. C. and Mezo, A. R. and Sherman, J. C.}
}
