@article {KURAKINA2021,
	title = {Improved separation scheme for 44Sc produced by irradiation of natCa targets with 12.8 MeV protons},
	journal = {Nucl. Med. Biol.},
	volume = {104-105},
	year = {2022},
	month = {11/2021},
	pages = {22-27},
	abstract = {<p>Introduction 44Sc is of great interest as a positron emission tomography (PET) radionuclide due to its suitable nuclear characteristics: Eβ+max = 1.47MeV, branching ratio 94.3\% and convenient half-life of 3.97 h. Here, 44Sc was produced via the widely used reaction 44Ca (p,n)44Sc using natural calcium as a target. Methods The irradiation was performed at TRIUMF using the 13 MeV cyclotron. The separation consisted of a combination of DGA branched resin and Dowex 50Wx8 (200\&ndash;400 mesh). The distribution coefficients of Sc3+ on Dowex 50Wx8 (NH4+ form, 200\&ndash;400 mesh) with ammonium α-hydroxyisobutyrate (pH = 4.8) medium were determined in this study. Results and conclusion The tested scheme allows both a reliable separation of 44Sc from the target material as well as from the other competitive metals and a final fraction with high specific activity. The achieved radiochemical yield was 95 \&plusmn; 3\%.</p>},
	keywords = {Cation exchange, DGA, Irradiation of natural Ca, Radiochemical separation, radiolabeling, Sc},
	issn = {0969-8051},
	doi = {https://doi.org/10.1016/j.nucmedbio.2021.11.002},
	url = {https://www.sciencedirect.com/science/article/pii/S0969805121005102},
	author = {E.S. Kurakina and L. Wharton and C. Hoehr and C. Orvig and E.P. Magomedbekov and D. Filosofov and V. Radchenko}
}
@article {RADCHENKO201639,
	title = {Separation of 44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44Ti/44Sc generator system},
	journal = {Journal of Chromatography A},
	volume = {1477},
	year = {2016},
	pages = {39 - 46},
	abstract = {Scandium-44g (half-life 3.97h [1]) shows promise for positron emission tomography (PET) imaging of longer biological processes than that of the current gold standard, 18F, due to its favorable decay parameters. One source of 44gSc is the long-lived parent nuclide 44Ti (half-life 60.0 a). A 44Ti/44gSc generator would have the ability to provide radionuclidically pure 44gSc on a daily basis. The production of 44Ti via the 45Sc(p,2n) reaction requires high proton beam currents and long irradiation times. Recovery and purification of no-carrier added (nca) 44Ti from scandium metal targets involves complex separation chemistry. In this study, separation systems based on solid phase extraction chromatography were investigated, including branched diglycolamide (BDGA) resin and hydroxamate based ZR resin. Results indicate that ZR resin in HCl media represents an effective 44Ti/44gSc separation system.},
	keywords = {BDGA, Sc, Scandium metal target, Solid phase extraction chromatography, Ti, ZR resin},
	issn = {0021-9673},
	doi = {https://doi.org/10.1016/j.chroma.2016.11.047},
	url = {http://www.sciencedirect.com/science/article/pii/S0021967316315795},
	author = {V. Radchenko and C.A.L. Meyer and J.W. Engle and C.M. Naranjo and G.A. Unc and T. Mastren and M. Brugh and E.R. Birnbaum and K.D. John and F.M. Nortier and M.E. Fassbender}
}
