@article {KOSTELNIK2023108352,
	title = {Production and radiochemistry of antimony-120m: Efforts toward Auger electron therapy with 119Sb},
	journal = {Nucl. Med. Biol.},
	volume = {122-123},
	year = {2023},
	month = {06/2023},
	pages = {108352},
	abstract = {<p>Targeted Meitner-Auger Therapy (TMAT) has potential for personalized treatment thanks to its subcellular dosimetric selectivity, which is distinct from the dosimetry of β\&minus; and α particle emission based Targeted Radionuclide Therapy (TRT). To date, most clinical and preclinical TMAT studies have used commercially available radionuclides. These studies showed promising results despite using radionuclides with theoretically suboptimal photon to electron ratios, decay kinetics, and electron emission spectra. Studies using radionuclides whose decay characteristics are considered more optimal are therefore important for evaluation of the full potential of Meitner-Auger therapy; 119Sb is among the best such candidates. In the present work, we develop radiochemical purification of 120Sb from irradiated natural tin targets for TMAT studies with 119Sb.</p>},
	keywords = {Antimony-119, Liquid-liquid extraction, Natural tin, Proton irradiation, Targeted Meitner-Auger Therapy},
	issn = {0969-8051},
	doi = {https://doi.org/10.1016/j.nucmedbio.2023.108352},
	url = {https://www.sciencedirect.com/science/article/pii/S0969805123000392},
	author = {Thomas I. Kostelnik and Aeli P. Olson and Aivija Grundmane and Paul A. Ellison and Jenasee Mynerich and Shaohuang Chen and Atanaska Marinova and Parmissa Randhawa and Dimitar Karaivanov and Eduardo Aluicio-Sarduy and Todd E. Barnhart and Chris Orvig and Caterina F. Ramogida and Cornelia Hoehr and Dmitry Filosofov and Jonathan W. Engle and Valery Radchenko}
}
@article {MASTREN201875,
	title = {Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix},
	journal = {Analytica Chimica Acta},
	volume = {998},
	year = {2018},
	pages = {75 - 82},
	abstract = {Column chromatographic methods have been developed to separate no-carrier-added 111Ag from proton irradiated thorium targets and associated fission products as an ancillary process to an existing 225Ac separation design. Herein we report the separation of 111Ag both prior and subsequent to 225Ac recovery using CL resin, a solvent impregnated resin (SIR) that carries an organic solution of alkyl phosphine sulfides (R3P~=~S) and alkyl phosphine oxides (R3P~=~O). The recovery yield of 111Ag was 93~{\textpm}~9\% with a radiochemical purity of 99.9\% (prior) and 87~{\textpm}~9\% with a radiochemical purity of 99.9\% (subsequent to) 225Ac recovery. Both processes were successfully performed with insignificant impacts on 225Ac yields or quality. Measured equilibrium distribution coefficients for silver and ruthenium (a residual contaminant) on CL resin in hydrochloric and nitric acid media are reported, to the best of our knowledge, for the first time. Additionally, measured cross sections for the production of 111Ag and 110mAg for the 232Th(p,f)110m,111Ag reactions are reported within.},
	keywords = {AG, CL resin, Nuclear reaction cross sections, Proton irradiation, Theranostic, Thorium target},
	issn = {0003-2670},
	doi = {https://doi.org/10.1016/j.aca.2017.10.020},
	url = {http://www.sciencedirect.com/science/article/pii/S0003267017311790},
	author = {Tara Mastren and Valery Radchenko and Jonathan W. Engle and John W. Weidner and Allison Owens and Lance E. Wyant and Roy Copping and Mark Brugh and F. Meiring Nortier and Eva R. Birnbaum and Kevin D. John and Michael E. Fassbender}
}
@article {RADCHENKO201725,
	title = {Proton-induced production and radiochemical isolation of 44Ti from scandium metal targets for 44Ti/44Sc generator development},
	journal = {Nuclear Medicine and Biology},
	volume = {50},
	year = {2017},
	pages = {25 - 32},
	abstract = {Scandium-44g (half-life 3.97h) shows promise for application in positron emission tomography (PET), due to favorable decay parameters. One of the sources of 44gSc is the 44Ti/44gSc generator, which can conveniently provide this radioisotope on a daily basis at a diagnostic facility. Titanium-44 (half-life 60.0 a), in turn, can be obtained via proton irradiation of scandium metal targets. A substantial 44Ti product batch, however, requires high beam currents, long irradiation times and an elaborate chemical procedure for 44Ti isolation and purification. This study describes the production of a combined 175MBq (4.7mCi) batch yield of 44Ti in week long proton irradiations at the Los Alamos Isotope Production Facility (LANL-IPF) and the Brookhaven Linac Isotope Producer (BNL-BLIP). A two-step ion exchange chromatography based chemical separation method is introduced: first, a coarse separation of 44Ti via anion exchange sorption in concentrated HCl results in a 44Tc/Sc separation factor of 102{\textendash}103. A second, cation exchange based step in HCl media is then applied for 44Ti fine purification from residual Sc mass. In summary, this method yields a 90{\textendash}97\% 44Ti recovery with an overall Ti/Sc separation factor of >=106.},
	keywords = {Ion exchange chromatography, Proton irradiation, Scandium target, Ti, Ti/Sc generator},
	issn = {0969-8051},
	doi = {https://doi.org/10.1016/j.nucmedbio.2017.03.006},
	url = {http://www.sciencedirect.com/science/article/pii/S0969805116304115},
	author = {Valery Radchenko and Jonathan W. Engle and Dmitri G. Medvedev and Joel M. Maassen and Cleo M. Naranjo and George A. Unc and Catherine A.L. Meyer and Tara Mastren and Mark Brugh and Leonard Mausner and Cathy S. Cutler and Eva R. Birnbaum and Kevin D. John and F. Meiring Nortier and Michael E. Fassbender}
}
@article {GRISWOLD2016366,
	title = {Large scale accelerator production of 225Ac: Effective cross sections for 78{\textendash}192MeV protons incident on 232Th targets},
	journal = {Applied Radiation and Isotopes},
	volume = {118},
	year = {2016},
	pages = {366 - 374},
	abstract = {Actinium-225 and 213Bi have been used successfully in targeted alpha therapy (TAT) in preclinical and clinical research. This paper is a continuation of research activities aiming to expand the availability of 225Ac. The high-energy proton spallation reaction on natural thorium metal targets has been utilized to produce millicurie quantities of 225Ac. The results of sixteen irradiation experiments of thorium metal at beam energies between 78 and 192MeV are summarized in this work. Irradiations have been conducted at Brookhaven National Laboratory (BNL) and Los Alamos National Laboratory (LANL), while target dissolution and processing was carried out at Oak Ridge National Laboratory (ORNL). Excitation functions for actinium and thorium isotopes, as well as for some of the fission products, are presented. The cross sections for production of 225Ac range from 3.6 to 16.7mb in the incident proton energy range of 78{\textendash}192MeV. Based on these data, production of curie quantities of 225Ac is possible by irradiating a 5.0gcm-2 232Th target for 10 days in either BNL or LANL proton irradiation facilities.},
	keywords = {Ac, actinium, Alpha-emitting, Ba, Ce, MO, Proton irradiation, RADIOTHERAPY, Th, Thorium},
	issn = {0969-8043},
	doi = {https://doi.org/10.1016/j.apradiso.2016.09.026},
	url = {http://www.sciencedirect.com/science/article/pii/S0969804316307795},
	author = {J.R. Griswold and D.G. Medvedev and J.W. Engle and R. Copping and J.M. Fitzsimmons and V. Radchenko and J.C. Cooley and M.E. Fassbender and D.L. Denton and K.E. Murphy and A.C. Owens and E.R. Birnbaum and K.D. John and F.M. Nortier and D.W. Stracener and L.H. Heilbronn and L.F. Mausner and S. Mirzadeh}
}
