@article {3223,
	title = {EVIDENCE FOR ENERGY-DEPENDENT TRANSPORT OF ALUMINUM OUT OF BRAIN EXTRACELLULAR FLUID},
	journal = {Toxicology},
	volume = {98},
	number = {1-3},
	year = {1995},
	note = {ISI Document Delivery No.: QX943Times Cited: 22Cited Reference Count: 36},
	month = {Apr},
	pages = {31-39},
	type = {Article},
	abstract = {Aluminum (Al) can cause CNS toxicity. The mechanism of its blood-brain barrier (BBB) permeation is poorly understood. In this study, microdialysis was used to determine extracellular fluid (ECF) unbound aluminum distribution between frontal cortex (FC) and blood during steady-state aluminum concentrations. The brain/blood aluminum ratio was determined. Over a 16-fold range of aluminum concentrations (dosed as aluminum citrate), brain/blood aluminum ratios were 0.10-0.15, consistently and significantly <1. Aluminum diffusion cannot account for these results, suggesting the presence of a carrier that moves aluminum out of brain extracellular fluid. These aluminum brain/blood ratios (BBRs) were not significantly different over the range of concentrations studied, suggesting an inability to saturate the carrier. Brain/blood aluminum ratios obtained with four aluminum-hydroxypyridinones were also significantly <1 (0.1-0.3), and were generally significantly different among themselves and from the aluminum citrate BBR. Movement of a BBB permeability marker from blood into brain extracellular fluid suggested partial BBB opening. The aluminum BBRs obtained (all much less than 1), in the presence of a partially opened BBR, suggest an efficient carrier moving aluminum out of brain ECF. Addition of cyanide to the brain microdialysis probe solution significantly increased the Al (citrate) BBR to 1, These results suggest the presence of an efficient, energy-dependent carrier that removes aluminum from brain ECF, either into brain cells or blood.},
	keywords = {aluminum, ANTIPYRINE, BARRIER, BLOOD, BLOOD-BRAIN BARRIER, CHELATORS INVITRO, COMPLEXES, ENERGY-DEPENDENT ACTIVE TRANSPORT, INVIVO MICRODIALYSIS, iron, MICRODIALYSIS, MOBILIZATION, permeability, TRANSFERRIN},
	isbn = {0300-483X},
	url = {<Go to ISI>://A1995QX94300004},
	author = {Allen, D. D. and Orvig, Chris and Yokel, R. A.}
}
@article {7283,
	title = {COMPLEXATION OF IRON WITH THE ORALLY ACTIVE DECORPORATION DRUG-L1 (3-HYDROXY-1,2-DIMETHYL-4-PYRIDINONE)},
	journal = {Clinical Chemistry},
	volume = {38},
	number = {4},
	year = {1992},
	note = {ISI Document Delivery No.: HN921Times Cited: 18Cited Reference Count: 37},
	month = {Apr},
	pages = {562-565},
	type = {Note},
	abstract = {{The stability constants for the Fe(III) complexes of the orally active iron decorporation drug L1 (3-hydroxy-1,2-dimethyl-4-pyridinone) have been determined by potentiometric titration [glass electrode, 25.0-degrees-C},
	keywords = {2-DIMETHYL-3-HYDROXYPYRID-4-ONE L1, aluminum, CHELATOR 1, CHEMISTRY, DESFERRIOXAMINE, EQUILIBRIUM, gallium, HETEROAROMATIC CHELATORS, IRON OVERLOAD, IRON-BINDING DRUGS, LONG-TERM TRIAL, MOBILIZATION, POTENTIOMETRIC TITRATION, PROGRAM},
	isbn = {0009-9147},
	url = {<Go to ISI>://A1992HN92100022},
	author = {Kline, M. A. and Orvig, Chris}
}
