@article {5209,
	title = {Coordination chemistry of vanadium in metallopharmaceutical candidate compounds},
	journal = {Coordination Chemistry Reviews},
	volume = {219},
	year = {2001},
	note = {ISI Document Delivery No.: 478JQTimes Cited: 138Cited Reference Count: 119},
	month = {Sep-Oct},
	pages = {1033-1053},
	type = {Review},
	abstract = {The discovery of vanadium{\textquoteright}s insulin-like behaviour in vitro, and later of the orally available glucose- and lipid-lowering capability of these same compounds in vivo, has stimulated renewed interest in vanadium coordination chemistry. Besides the anti-diabetic effects for which it is now so well known, vanadium also exhibits a number of other therapeutic effects including anti-tumour and anti-inflammatory activities. In this review, emphasis will be on the most recent developments in the coordination chemistry of vanadium(III), (IV) and (V), as related to development of these compounds for pharmaceutical use. How best to measure bioactivity and the pharmaceutical relevance of accompanying increased oxidative stress will also be considered. (C) 2001 Elsevier Science B.V. All rights reserved.},
	keywords = {bioactivity, BIOLOGICAL-ACTIVITY, CANCER, CRYSTAL-STRUCTURE, Diabetes mellitus, DIABETES-MELLITUS, ESEEM, INSULIN-LIKE ACTIVITIES, OXIDATIVE STRESS, OXOVANADIUM(IV) COMPLEXES, OXYGEN-BRIDGED DIMER, PEROXO HETEROLIGAND VANADATES(V), pharmaceutical agents, RAY, SPECTROSCOPIC PROPERTIES, structure-activity relationships, TYROSINE PHOSPHORYLATION, vanadium complexes},
	isbn = {0010-8545},
	url = {<Go to ISI>://000171343600035},
	author = {Thompson, K. H. and Orvig, Chris}
}
@article {4957,
	title = {Design of vanadium compounds as insulin enhancing agents},
	journal = {Journal of the Chemical Society-Dalton Transactions},
	number = {17},
	year = {2000},
	note = {ISI Document Delivery No.: 348MDTimes Cited: 77Cited Reference Count: 123},
	pages = {2885-2892},
	type = {Review},
	abstract = {Vanadium compounds, in vitro, stimulate glucose uptake and inhibit lipid breakdown, in a manner remarkably reminiscent of insulin{\textquoteright}s effects. In vivo, vanadium enhances insulin{\textquoteright}s plasma glucose and lipid-lowering properties, leading to normalization of diabetic symptoms in the presence of only minimal endogenous insulin. The coordination chemistry of vanadium has great versatility for adjustment of pharmacological characteristics. Vanadium compounds are generally also very redox active, which is both advantageous and detrimental for optimizing biochemical function. In this perspective, we review and comment on how these properties have been revealed, what questions have arisen along the way, and where future investigations may be headed. While this is not a comprehensive overview of all available compounds touted as {\textquoteright}insulin enhancing agents{\textquoteright}, it will focus on those which are distinctive in some way, or which are representative of the larger library of vanadium compounds, including all currently known relevant oxidation states of vanadium.},
	keywords = {AGENT, BIOLOGICAL-SYSTEMS, DEPENDENT DIABETES-MELLITUS, ECHO ENVELOPE, GLUCOSE-METABOLISM, IN-VIVO, MIMETIC, MODULATION, PEROXOVANADIUM COMPOUNDS, SKELETAL-MUSCLE, STREPTOZOTOCIN-TREATED RATS, TYROSINE PHOSPHORYLATION},
	isbn = {1470-479X},
	url = {<Go to ISI>://000088987800001},
	author = {Thompson, K. H. and Orvig, Chris}
}
@article {4683,
	title = {Vanadium compounds as insulin mimics},
	journal = {Chemical Reviews},
	volume = {99},
	number = {9},
	year = {1999},
	note = {ISI Document Delivery No.: 235XUTimes Cited: 376Cited Reference Count: 124},
	month = {Sep},
	pages = {2561-2571},
	type = {Review},
	keywords = {AGENT BIS(MALTOLATO)OXOVANADIUM(IV) BMOV, BIOLOGICAL-SYSTEMS, COMPOUNDS, GLUCOSE-METABOLISM, IN-VIVO, MIMETIC AGENT, OXIDATIVE STRESS, PEROXOVANADIUM, PHOSPHOTYROSINE PHOSPHATASE INHIBITORS, STREPTOZOTOCIN-DIABETIC RATS, TYROSINE PHOSPHORYLATION},
	isbn = {0009-2665},
	url = {<Go to ISI>://000082569800015},
	author = {Thompson, K. H. and McNeill, J. H. and Orvig, Chris}
}
