@article {KHAN2019333,
	title = {In~vitro and in~vivo anti-tumor activity of two gold(III) complexes with isoquinoline derivatives as ligands},
	journal = {Eur. J. Med. Chem.},
	volume = {163},
	year = {2019},
	pages = {333 - 343},
	abstract = {<p>Two gold(III) complexes of isoquinoline derivatives: [Au(L1)Cl2] (Au1) and [Au(L2)Cl2] (Au2) have been prepared and characterized. Au1 and Au2 exhibited greater cytotoxicity than their corresponding ligands and cisplatin against T-24 cells. Both complexes arrested cell cycle at S-phase by upregulation of p53, p27, and p21, and downregulation of cyclin A and cyclin E. The depolarization of the mitochondrial membrane potential, generation of ROS, and stimulated Ca2+ release activated the caspase cascade and ultimately caused apoptosis by increasing the levels of Bax and Bak, and decreasing the levels of Bcl-2 and Bcl-xl. Cell apoptosis was achieved via mitochondria mediated pathways. The in\&nbsp;vivo studies of Au1 and Au2 demonstrated that they were safer than cisplatin and could effectively inhibit tumor growth.</p>},
	keywords = {ANTITUMOR ACTIVITY, Cell apoptosis, Gold(III) complexes, Isoquinoline, Mitochondrial dysfunction},
	issn = {0223-5234},
	doi = {https://doi.org/10.1016/j.ejmech.2018.11.047},
	url = {http://www.sciencedirect.com/science/article/pii/S0223523418310067},
	author = {Taj-Malook Khan and Noor Shad Gul and Xing Lu and Jian-Hua Wei and Yan-Cheng Liu and Hongbin Sun and Hong Liang and Chris Orvig and Zhen-Feng Chen}
}
@article {1204,
	title = {Synthesis and characterization of dual function vanadyl, gallium and indium curcumin complexes for medicinal applications},
	journal = {Journal of Inorganic Biochemistry},
	volume = {99},
	number = {11},
	year = {2005},
	note = {ISI Document Delivery No.: 984RUTimes Cited: 22Cited Reference Count: 41},
	month = {Nov},
	pages = {2217-2225},
	type = {Article},
	abstract = {Novel bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione (curcumin) complexes with the formula, ML3, where M is Ga(III) or In(III), or of the formula, ML2 where M is [Vo](2+), have been synthesized and characterized by mass spectrometry, infrared and absorption spectroscopies, and elemental analysis. A new ligand, bis[4-acetyl-3-hydroxyphenyl]-1,6-heptadiene-3,5-dione (diacetylbisdemethoxycurcumin, DABC) was similarly characterized; an X-ray structure analysis was performed. Vanadyl complexes tested in an acute i.p. testing protocol in STZ-diabetic rats showed a lack of insulin enhancing potential. Vanadyl complexes were, however, more cytotoxic than were the ligands alone in standard MTT (3-[4,5-dimethylthiazole-2-yl]ate, -2.5-diphenyl-tetrazolium bromide) cytotoxicity testing, using mouse lymphoma cells. With the exception of DABC, that was not different from VO(DABC)(2), the complexes were not significantly different from one another, with IC50 values in the 5-10 mu M range. Gallium and indium curcumin complexes had IC50 values in the same 5-10 mu M range; whereas Ga(DAC)(3) and In(DAC)(3) (where DAC = diacetylcurcumin) were much less cytotoxiC (IC50 = 20-30 mu M). Antioxidant capacity was decreased in VO(DAC)(2), Ga(DAC)(3), and In(DAC)(3),, compared to vanadyl, gallium and indium curcumin, corroborating the importance of curcumin{\textquoteright}s free phenolic OH groups for scavenging oxidants, and correlated with reduced cytotoxic potential. (c) 2005 Elsevier Inc. All rights reserved.},
	keywords = {ANALOGS, antioxidant capacity, ANTIOXIDANT MECHANISM, ANTITUMOR ACTIVITY, BINDING, COORDINATION CHEMISTRY, curcumin, cytotoxicity, DERIVATIVES, diacetylcurcumin, gallium, GROUP, indium, INSULIN MIMICS, MANGANESE COMPLEXES, RADICAL SCAVENGING ABILITY, TOXICITY, VANADIUM},
	isbn = {0162-0134},
	url = {<Go to ISI>://000233322800012},
	author = {Mohammadi, K. and Thompson, K. H. and Patrick, B. O. and Storr, T. and Martins, C. and Polishchuk, E. and Yuen, V. G. and McNeill, J. H. and Orvig, Chris}
}
