@article {2243,
	title = {Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer{\textquoteright}s disease},
	journal = {Dalton Transactions},
	number = {45},
	year = {2008},
	note = {ISI Document Delivery No.: 371METimes Cited: 5Cited Reference Count: 29Scott, Lauren E. Page, Brent D. G. Patrick, Brian O. Orvig, Chris},
	pages = {6364-6367},
	type = {Article},
	abstract = {Selective design modifications of specifically substituted 3-hydroxy-4(1H)-pyridinones show possibly advantageous ring freedom while maintaining metal-binding ability and antioxidant capacity, moving toward an efficient potential treatment for Alzheimer{\textquoteright}s disease.},
	keywords = {aluminum, BLOOD-BRAIN-BARRIER, COMPLEXES, DISORDERS, DIVALENT, IRON CHELATORS, PENETRATION, STABILITIES, therapy, TRIVALENT METAL-IONS},
	isbn = {1477-9226},
	url = {<Go to ISI>://000260834600005},
	author = {Scott, L. E. and Page, B. D. G. and Patrick, B. O. and Orvig, Chris}
}
@article {7397,
	title = {POTENTIAL GA-67 RADIOPHARMACEUTICALS FOR MYOCARDIAL IMAGING - TRIS(1-ARYL-3-HYDROXY-2-METHYL-4-PYRIDINONATO)GALLIUM(III) COMPLEXES},
	journal = {Nuclear Medicine and Biology},
	volume = {19},
	number = {3},
	year = {1992},
	note = {ISI Document Delivery No.: HL213Times Cited: 36Cited Reference Count: 33},
	month = {Apr},
	pages = {327-335},
	type = {Article},
	abstract = {A series of highly lipophilic complexes of 1-aryl-3-hydroxy-2-methyl-4-pyridinones with gallium(III)-67 has been evaluated in vitro and in vivo as potential radiopharmaceuticals. The pyridinones have different substituents at the para -position of the phenyl ring: R = H, CH3, OCH3 and NO2. Biodistribution studies of Ga-67 complexes have been carried out in rabbits, mice, rats and a dog. High heart uptake of the radionuclide has been shown in rabbits and the dog. The different biodistribution patterns in mice and rats indicate that there is a species difference in the biodistribution of these complexes. Rabbits and the dog show rapid heart uptake and blood clearance. The speciation of the Ga3+ ion in vivo is simulated in vitro with a simple blood plasma model based on the available thermodynamic data.},
	keywords = {3-HYDROXY-4-PYRIDINONES, aluminum, BIODISTRIBUTION, CHELATING LIGAND, CHEMISTRY, gallium, INDIUM COMPLEXES, MULTIDENTATE LIGANDS, N, N{\textquoteright}-DIACETIC ACID, N{\textquoteright}-DIPYRIDOXYLETHYLENEDIAMINE-N, TRIVALENT METAL-IONS},
	isbn = {0883-2897},
	url = {<Go to ISI>://A1992HL21300012},
	author = {Zhang, Z. H. and Lyster, D. M. and Webb, G. A. and Orvig, Chris}
}
