@article {2369,
	title = {Long-chain rhenium and technetium glucosamine conjugates},
	journal = {Dalton Transactions},
	number = {42},
	year = {2009},
	note = {ISI Document Delivery No.: 508YBTimes Cited: 0Cited Reference Count: 44Bowen, Meryn L. Chen, Zhen-Feng Roos, Adrienne M. Misri, Ripen Haefeli, Urs Adam, Michael J. Orvig, Chris},
	pages = {9228-9236},
	type = {Article},
	abstract = {A series of five glucosamine-conjugated organometallic complexes of the tricarbonyl cores of technetium-99m and rhenium were made. Glucosamine was derivatized at the C-2 nitrogen with long chain alkyl spacers linked to either pyridyl-tert-nitrogen-phenol tridentate chelates or cyclopentadienyl ligating groups. The metal complexes of the tridentate ligands were formed by refluxing with [Re(CO)(3)(H2O)(3)]Br, or with a base and [Tc-99m(CO)(3)(H2O)(3)](+). These ligands were found to be competent chelates in binding the [Tc-99m(CO)(3)](+) core as radiolabeling yields ranged from 87 to 93\% and the resulting complexes are stable to cysteine and histidine challenges for 24 h. The cyclopentadienyl analogues were formed using a double ligand transfer reaction for the rhenium complexes and a single ligand transfer for the technetium-99m complexes. All five rhenium complexes were tested as substrates of hexokinase; two of these complexes were tested as hexokinase inhibitors and they were found to be competent inhibitors, suggesting that they may be able to interact with hexokinase. MTT cytotoxicity studies were performed and the complexes tested were found to be non-toxic to the concentrations tested (100 mu M or 1 mM). GLUT-1 mediated cell uptake studies were performed on all five technetium-99m complexes, and their cell entry was found to parallel their lipophilicities, suggesting that cellular uptake is by passive diffusion and is not mediated by GLUT-1.},
	keywords = {99M-TECHNETIUM, BIOMOLECULES, BREAST-CANCER, DERIVATIVES, HEXOKINASE, IN-VITRO, METAL-COMPLEXES, RE, TC-99M, TRANSPORT},
	isbn = {1477-9226},
	url = {<Go to ISI>://000270973800021},
	author = {Bowen, M. L. and Chen, Z. F. and Roos, A. M. and Misri, R. and Hafeli, U. and Adam,Michael J. and Orvig, Chris}
}
@article {2369,
	title = {Long-chain rhenium and technetium glucosamine conjugates},
	journal = {Dalton Transactions},
	number = {42},
	year = {2009},
	note = {ISI Document Delivery No.: 508YBTimes Cited: 0Cited Reference Count: 44Bowen, Meryn L. Chen, Zhen-Feng Roos, Adrienne M. Misri, Ripen Haefeli, Urs Adam, Michael J. Orvig, Chris},
	pages = {9228-9236},
	type = {Article},
	abstract = {A series of five glucosamine-conjugated organometallic complexes of the tricarbonyl cores of technetium-99m and rhenium were made. Glucosamine was derivatized at the C-2 nitrogen with long chain alkyl spacers linked to either pyridyl-tert-nitrogen-phenol tridentate chelates or cyclopentadienyl ligating groups. The metal complexes of the tridentate ligands were formed by refluxing with [Re(CO)(3)(H2O)(3)]Br, or with a base and [Tc-99m(CO)(3)(H2O)(3)](+). These ligands were found to be competent chelates in binding the [Tc-99m(CO)(3)](+) core as radiolabeling yields ranged from 87 to 93\% and the resulting complexes are stable to cysteine and histidine challenges for 24 h. The cyclopentadienyl analogues were formed using a double ligand transfer reaction for the rhenium complexes and a single ligand transfer for the technetium-99m complexes. All five rhenium complexes were tested as substrates of hexokinase; two of these complexes were tested as hexokinase inhibitors and they were found to be competent inhibitors, suggesting that they may be able to interact with hexokinase. MTT cytotoxicity studies were performed and the complexes tested were found to be non-toxic to the concentrations tested (100 mu M or 1 mM). GLUT-1 mediated cell uptake studies were performed on all five technetium-99m complexes, and their cell entry was found to parallel their lipophilicities, suggesting that cellular uptake is by passive diffusion and is not mediated by GLUT-1.},
	keywords = {99M-TECHNETIUM, BIOMOLECULES, BREAST-CANCER, DERIVATIVES, HEXOKINASE, IN-VITRO, METAL-COMPLEXES, RE, TC-99M, TRANSPORT},
	isbn = {1477-9226},
	url = {<Go to ISI>://000270973800021},
	author = {Bowen, M. L. and Chen, Z. F. and Roos, A. M. and Misri, R. and Hafeli, U. and Adam,Michael J. and Orvig, Chris}
}
