@article {2370,
	title = {Glucosamine conjugates bearing N,N,O-donors: potential imaging agents utilizing the [M(CO)(3)](+) core (M = Re, Tc)},
	journal = {Dalton Transactions},
	number = {42},
	year = {2009},
	note = {ISI Document Delivery No.: 508YBTimes Cited: 2Cited Reference Count: 32Bowen, Meryn L. Lim, Nathaniel C. Ewart, Charles B. Misri, Ripen Ferreira, Cara L. Haefeli, Urs Adam, Michael J. Orvig, Chris},
	pages = {9216-9227},
	type = {Article},
	abstract = {The design rationale, synthesis and radiolabeling evaluation of four glucosamine conjugated ligands for the [Tc-99m(CO)(3)](+) core is described. The capability to bind the tricarbonyl core is initially demonstrated using the cold surrogate [Re(CO)(3)](+). The four compounds are competent chelates in binding [Tc-99m(CO)(3)](+) as labeling studies show, with yields ranging from 79 to 96\% and the resulting complexes showing stability in the presence of competing chelates for 24 h at 37 degrees C. The rhenium complexes were tested for hexokinase-catalysed phosphorylation, and the technetium complexes were tested for GLUT-1 mediated cell uptake - they showed a small amount of uptake but it was not glucose dependent, suggesting that it was not via the GLUT-1 transporters.},
	keywords = {BIOMOLECULES, EXPRESSION, GLUT-1, HEXOKINASE, IN-VITRO, METAL-COMPLEXES, TC-99M, technetium, TRANSPORTERS, TRICARBONYL COMPLEXES},
	isbn = {1477-9226},
	url = {<Go to ISI>://000270973800020},
	author = {Bowen, M. L. and Lim, N. C. and Ewart, C. B. and Misri, R. and Ferreira, C. L. and Hafeli, U. and Adam,Michael J. and Orvig, Chris}
}
@article {2370,
	title = {Glucosamine conjugates bearing N,N,O-donors: potential imaging agents utilizing the [M(CO)(3)](+) core (M = Re, Tc)},
	journal = {Dalton Transactions},
	number = {42},
	year = {2009},
	note = {ISI Document Delivery No.: 508YBTimes Cited: 2Cited Reference Count: 32Bowen, Meryn L. Lim, Nathaniel C. Ewart, Charles B. Misri, Ripen Ferreira, Cara L. Haefeli, Urs Adam, Michael J. Orvig, Chris},
	pages = {9216-9227},
	type = {Article},
	abstract = {The design rationale, synthesis and radiolabeling evaluation of four glucosamine conjugated ligands for the [Tc-99m(CO)(3)](+) core is described. The capability to bind the tricarbonyl core is initially demonstrated using the cold surrogate [Re(CO)(3)](+). The four compounds are competent chelates in binding [Tc-99m(CO)(3)](+) as labeling studies show, with yields ranging from 79 to 96\% and the resulting complexes showing stability in the presence of competing chelates for 24 h at 37 degrees C. The rhenium complexes were tested for hexokinase-catalysed phosphorylation, and the technetium complexes were tested for GLUT-1 mediated cell uptake - they showed a small amount of uptake but it was not glucose dependent, suggesting that it was not via the GLUT-1 transporters.},
	keywords = {BIOMOLECULES, EXPRESSION, GLUT-1, HEXOKINASE, IN-VITRO, METAL-COMPLEXES, TC-99M, technetium, TRANSPORTERS, TRICARBONYL COMPLEXES},
	isbn = {1477-9226},
	url = {<Go to ISI>://000270973800020},
	author = {Bowen, M. L. and Lim, N. C. and Ewart, C. B. and Misri, R. and Ferreira, C. L. and Hafeli, U. and Adam,Michael J. and Orvig, Chris}
}
@article {2024,
	title = {99m-Technetium carbohydrate conjugates as potential agents in molecular imaging},
	journal = {Chemical Communications},
	number = {41},
	year = {2008},
	note = {ISI Document Delivery No.: 365LHTimes Cited: 19Cited Reference Count: 97Bowen, Meryn L. Orvig, Chris},
	pages = {5077-5091},
	type = {Article},
	abstract = {This feature article covers recent reports of work towards the development of Tc-99m-carbohydrate based agents for use in SPECT imaging, particularly of cancerous tissue. An outline of some of the key biological functions and coordination chemistry of carbohydrates is given, along with an introduction to bioconjugation and molecular imaging. Technetium coordination chemistry and the subset of this involving bioconjugates are discussed before moving into the focus of the article: glycoconjugates of Tc-99m(v) and the more recently developed [Tc-99m(I)(CO)(3)](+). Significant work in the last decade has featured the very attractive [Tc-99m(CO)(3)](+) core, and the ligand sets designed for this core are discussed in detail.},
	keywords = {ANTITUMOR-ACTIVITY, BIFUNCTIONAL CHELATORS, BIOLOGICAL EVALUATION, D-GLUCOSE, IN-VITRO, ISOSTRUCTURAL RE, METAL-COMPLEXES, STRUCTURAL-CHARACTERIZATION, TC-99M COMPLEXES, TRICARBONYL COMPLEXES},
	isbn = {1359-7345},
	url = {<Go to ISI>://000260407400002},
	author = {Bowen, M. L. and Orvig, Chris}
}
@article {1390,
	title = {Carbohydrate-appended 3-hydroxy-4-pyridinone complexes of the [M(CO)(3)](+) core (M) Re, Tc-99m, Re-186)},
	journal = {Bioconjugate Chemistry},
	volume = {17},
	number = {5},
	year = {2006},
	note = {ISI Document Delivery No.: 085LXTimes Cited: 21Cited Reference Count: 69Ferreira, Cara L. Bayly, Simon R. Green, David E. Storr, Tim Barta, Cheri A. Steele, Jennifer Adam, Michael J. Orvig, Chris},
	month = {Sep},
	pages = {1321-1329},
	type = {Article},
	abstract = {This work describes the use of 3-hydroxy-4-pyridinone ligands for binding the [M(CO)(3)](+) core ( M) Re, Tc) in the context of preparing novel Tc( I) and Re( I) glucose conjugates. Five pyridinone ligands bearing pendent carbohydrate moieties, HL1-5, were coordinated to the [M(CO)(3)](+0) core on the macroscopic scale ( M) Re) and on the tracer scale (M) = Tc-99m, Re-186). On the macroscopic scale the complexes, ReL1-5(CO)(3)(H{\O}-2), were thoroughly characterized by mass spectrometry, IR spectroscopy, UV-visible spectroscopy, elemental analysis, and 1D/2D NMR spectroscopy. Characterization confirmed the bidentate coordination of the pyridinone and the pendent nature of the carbohydrate and suggests the presence of a water molecule in the sixth coordination site. In preliminary biological evaluation, both the ligands and complexes were assessed as potential substrates or inhibitors of hexokinase, but showed no activity. Labeling via the [Tc-99m(CO)(3)(H2O)(3)](+) precursor gave the tracer species (TcL1-5)-Tc-99m(CO)(3)(H2O) in high radiochemical yields. Similar high radiochemical yields when labeling with Re-186 were facilitated by in situ preparation of the [Re-186( CO)(3)(H2O)(3)](+) species in the presence of HL1-5 to give (ReL1-5)-Re-186(CO)(3)(H2O). Stability challenges, incubating (TcL1-5)-Tc-99m(CO)(3)(H2O) in the presence of excess cysteine and histidine, confirmed complex stability up to 24 h.},
	keywords = {5-HT1A RECEPTOR, BIFUNCTIONAL LIGAND, BIOMOLECULES, GLUCOSE, IMAGING AGENTS, IN-VITRO, METAL-COMPLEXES, STRUCTURAL-CHARACTERIZATION, TRICARBONYL COMPLEXES, TRIDENTATE LIGANDS},
	isbn = {1043-1802},
	url = {<Go to ISI>://000240606700027},
	author = {Ferreira, C. L. and Bayly, S. R. and Green, D. E. and Storr, T. and Barta, C. A. and Steele, J. and Adam,Michael J. and Orvig, Chris}
}
@article {1390,
	title = {Carbohydrate-appended 3-hydroxy-4-pyridinone complexes of the [M(CO)(3)](+) core (M) Re, Tc-99m, Re-186)},
	journal = {Bioconjugate Chemistry},
	volume = {17},
	number = {5},
	year = {2006},
	note = {ISI Document Delivery No.: 085LXTimes Cited: 21Cited Reference Count: 69Ferreira, Cara L. Bayly, Simon R. Green, David E. Storr, Tim Barta, Cheri A. Steele, Jennifer Adam, Michael J. Orvig, Chris},
	month = {Sep},
	pages = {1321-1329},
	type = {Article},
	abstract = {This work describes the use of 3-hydroxy-4-pyridinone ligands for binding the [M(CO)(3)](+) core ( M) Re, Tc) in the context of preparing novel Tc( I) and Re( I) glucose conjugates. Five pyridinone ligands bearing pendent carbohydrate moieties, HL1-5, were coordinated to the [M(CO)(3)](+0) core on the macroscopic scale ( M) Re) and on the tracer scale (M) = Tc-99m, Re-186). On the macroscopic scale the complexes, ReL1-5(CO)(3)(H{\O}-2), were thoroughly characterized by mass spectrometry, IR spectroscopy, UV-visible spectroscopy, elemental analysis, and 1D/2D NMR spectroscopy. Characterization confirmed the bidentate coordination of the pyridinone and the pendent nature of the carbohydrate and suggests the presence of a water molecule in the sixth coordination site. In preliminary biological evaluation, both the ligands and complexes were assessed as potential substrates or inhibitors of hexokinase, but showed no activity. Labeling via the [Tc-99m(CO)(3)(H2O)(3)](+) precursor gave the tracer species (TcL1-5)-Tc-99m(CO)(3)(H2O) in high radiochemical yields. Similar high radiochemical yields when labeling with Re-186 were facilitated by in situ preparation of the [Re-186( CO)(3)(H2O)(3)](+) species in the presence of HL1-5 to give (ReL1-5)-Re-186(CO)(3)(H2O). Stability challenges, incubating (TcL1-5)-Tc-99m(CO)(3)(H2O) in the presence of excess cysteine and histidine, confirmed complex stability up to 24 h.},
	keywords = {5-HT1A RECEPTOR, BIFUNCTIONAL LIGAND, BIOMOLECULES, GLUCOSE, IMAGING AGENTS, IN-VITRO, METAL-COMPLEXES, STRUCTURAL-CHARACTERIZATION, TRICARBONYL COMPLEXES, TRIDENTATE LIGANDS},
	isbn = {1043-1802},
	url = {<Go to ISI>://000240606700027},
	author = {Ferreira, C. L. and Bayly, S. R. and Green, D. E. and Storr, T. and Barta, C. A. and Steele, J. and Adam,Michael J. and Orvig, Chris}
}
