@article {5228,
	title = {Synthesis of 2,6-dideoxy-2-fluoro-6-[F-18]-fluoro-beta-D-glucopyranosyl fluoride (2,6FGF) as a potential imaging probe for glucocerebrosidase},
	journal = {Journal of Labelled Compounds \& Radiopharmaceuticals},
	volume = {44},
	number = {5},
	year = {2001},
	note = {ISI Document Delivery No.: 420VMTimes Cited: 4Cited Reference Count: 8},
	month = {Apr},
	pages = {385-394},
	type = {Article},
	abstract = {We have previously synthesized 2-deoxy-2-[F-18]-fluoro-beta -mannosyl [F-18]-fluoride and shown that it behaves as a mechanism-based inhibitor of Agrobacterium sp. beta -glucosidase. In-vivo experiments indicate that this compound undergoes partial hydrolysis to produce 2-deoxy-2-fluoro-mannose, which can become phosphorylated and trapped within the cell. We now report the synthesis of another 2-fluoro glycoside which is F-18-labelled at the 6 position so that the label cannot be lost during such glycoside hydrolysis and which, further, cannot be phosphorylated. The mechanism-based glycosidase inhibitor 2,6-dideoxy-2-fluoro-6-[F-18]-fluoro-beta -D-glucopyranosyl fluoride (2,6FGF) was synthesized in 69\% overall chemical yield and in 9\% radiochemical yield (decay corrected) as a potential imaging probe for glycosidase.},
	keywords = {2-fluoro-glucose, fluorine-18, Gaucher{\textquoteright}s disease, glycosidase, PET},
	isbn = {0362-4803},
	url = {<Go to ISI>://000168026000009},
	author = {Wong, A. W. and Adam,Michael J. and Withers, S. G.}
}
