@article {1007,
	title = {High affinity DNAzyme-based ligands for transition metal cations - a prototype sensor for Hg2+},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {2},
	number = {3},
	year = {2004},
	note = {ISI Document Delivery No.: 776YCTimes Cited: 32Cited Reference Count: 47},
	month = {Feb},
	pages = {307-312},
	type = {Article},
	abstract = {Inspired by recent interest in DNAzymes as transition metal ion sensors, a survey of the effects of various transition metals on the intramolecular cleavage rate of an imidazole modified, M2+-independent, self-cleaving "9(25)-11" DNA is reported. In particular, 9(25)-11 activity was strongly inhibited by Hg2+ (K-d(APP) = 110 +/- 9 nM). It is postulated that the affinity and selectivity of 9(25)-11 for Hg2+ stems from the fact that this synthetically modified DNAzyme contains imidazoles. This study demonstrates the utility of modified nucleotides in developing DNAzyme sensors for metals ions, especially those for which unmodified nucleic acids might not serve as inherently good ligands.},
	keywords = {2-STEP MECHANISM, BIOSENSOR, CATALYTIC REPERTOIRE, CLEAVING DNA ENZYME, IMIDAZOLYL FUNCTIONALITIES, MERCURIC ION, MERCURY(II), NUCLEIC-ACIDS, NUCLEOSIDES, SELECTION},
	isbn = {1477-0520},
	url = {<Go to ISI>://000189146100008},
	author = {Thomas, J. M. and Ting, R. and Perrin,David M.}
}
