@article {2289, title = {Capturing aqueous [F-18]-fluoride with an arylboronic ester for PET: Synthesis and aqueous stability of a fluorescent [F-18]-labeled aryltrifluoroborate}, journal = {Journal of Fluorine Chemistry}, volume = {129}, number = {5}, year = {2008}, note = {ISI Document Delivery No.: 302SWTimes Cited: 5Cited Reference Count: 12Ting, Richard Lo, Justin Adam, Michael J. Ruth, Thomas J. Perrin, David M.}, month = {May}, pages = {349-358}, type = {Article}, abstract = {The aqueous stability of aryltrifluoroborates is of importance to their use in transition metal mediated coupling reactions as well as their potential use in [F-18]-labeled aryltrifluoroborate PET imaging agents. Nevertheless, few studies have fully characterized the solvolysis of fluoride from an aryltrifluoroborate in water. Using [F-19] NMR, fluorescence and [F-18]-labeling techniques, we disclose the composition of an aryltrifluoroborate of exceptional kinetic stability with respect to solvolytic defluoridation. This work not only highlights the potential of using [F-18]-labeled aryltrifluoroborates for PET tracers, but provides a chemical platform and a general approach for evaluating the stability of other aryltrifluoroborates. (c) 2008 Elsevier B.V. All rights reserved.}, keywords = {ACIDS, aryltrifluoroborate, CROSS-COUPLING REACTIONS, KINETICS, PET, SYNTHESIS, [F-18]-labeling}, isbn = {0022-1139}, url = {://000255990600005}, author = {Ting, R. and Lo, J. and Adam,Michael J. and Ruth, T. J. and Perrin,David M.} }